Phenone, Hydroxybenzophenone, and Branched Phenone ER Binding and Vitellogenin Agonism in Rainbow Trout In Vitro Models [0.03%]
茋、羟基茋和支链茋的雌激素受体结合与卵蛋白原诱导效应及对虹彩鲤的毒性作用体外模型研究
Mark A Tapper,Jeffrey S Denny,Jose A Serrano et al.
Mark A Tapper et al.
Phenones and hydroxy benzophenones are widely used as UV radiation filters, and in the manufacturing of insecticides and pharmaceuticals. Understanding the estrogenic potential these chemicals is of interest to the US Environmental Protecti...
Estrogenic Activity of Perfluoro Carboxylic and Sulfonic Acids in Rainbow Trout Estrogen Receptor Binding and Liver Slice Vtg mRNA Expression Assays [0.03%]
全氟羧酸和磺酸的雌激素活性:以 rainbow trout 雌激素受体结合和肝切片vtg mrna 表达为检测指标
Mark A Tapper,Jeffrey S Denny,Barbara R Sheedy et al.
Mark A Tapper et al.
Perfluoroalkylated substances (PFAS) such as carboxylic acids, and sulfonic acids were manufactured in high quantities and are ubiquitous environmental contaminants. These chemicals persist in the environment and tend to bioaccumulate. In t...
Application of Defined Approaches to Assess Skin Sensitization Potency of Isothiazolinone Compounds [0.03%]
定义方法评估异噻唑啉酮化合物皮肤致敏强度的应用
Judy Strickland,David G Allen,Dori Germolec et al.
Judy Strickland et al.
Introduction: Isothiazolinones (ITs) are widely used as antimicrobial preservatives in cosmetics and as additives for preservation of consumer and industrial products to control bacteria, fungi, and algae. Although they a...
Characterization of Novel Human Immortalized Thyroid Follicular Epithelial Cell Lines [0.03%]
人甲状腺滤泡上皮细胞永生化细胞系的特征研究
Kristen Hopperstad,Theresa Truschel,Tom Wahlicht et al.
Kristen Hopperstad et al.
Introduction: Investigation of normal human thyroid function using in vitro culture systems is dependent on cells that recapitulate physiology of differentiated thyrocytes. Primary thyrocytes retain features of the native...
Providing Adverse Outcome Pathways from the AOP-Wiki in a Semantic Web Format to Increase Usability and Accessibility of the Content [0.03%]
以语义网格式提供AOP-wiki中的 adverse outcome pathways 以增加内容的易用性和可访问性
Marvin Martens,Chris T Evelo,Egon L Willighagen
Marvin Martens
Introduction: The AOP-Wiki is the main platform for the development and storage of adverse outcome pathways (AOPs). These AOPs describe mechanistic information about toxicodynamic processes and can be used to develop effe...
A Unidirectional 96-Well Fluidic Culture Platform for Upstream Cell Dosing with Subsequent Downstream Nonlinear and Ascending Exposure Gradients for Real-Time and Cell-Based Toxicity Screening Environments [0.03%]
一种单向的96孔流体培养平台，用于上游细胞剂量给药，并随后进行下游非线性和升序暴露梯度处理，以适应实时和基于细胞的毒性筛查环境
Bincy A John,David J Sloan,Timothy C Jensen et al.
Bincy A John et al.
Introduction: Because of the importance to create in vitro screening tools that better mimic in vivo models, for exposure responses to drugs or toxicants, reproducible and adaptable culture platforms must evolve as approaches to replicate f...
An Integrated Approach to Testing and Assessment to Support Grouping and Read-Across of Nanomaterials After Inhalation Exposure [0.03%]
一种综合测试和评估方法，以支持吸入暴露后纳米材料的分组和类比分析
Hedwig M Braakhuis,Fiona Murphy,Lan Ma-Hock et al.
Hedwig M Braakhuis et al.
Introduction: Here, we describe the generation of hypotheses for grouping nanoforms (NFs) after inhalation exposure and the tailored Integrated Approaches to Testing and Assessment (IATA) with which each specific hypothesis can be tested. T...
Correction to: An Integrative Proteomic/Lipidomic Analysis of the Gold Nanoparticle Biocorona in Healthy and Obese Conditions, by Kobos LM, et al. Appl In Vitro Toxicol 2019:5;150-166; DOI: 10.1089/aivt.2019.0005 [0.03%]
致：金纳米颗粒生物冠蛋白组/脂质组综合分析在健康和肥胖条件下文章的更正(Kobos LM等，Applied In Vitro Toxicology, 2019: 5; 150-166; DOI: 10.1089/aivt.2019.0005)
[This corrects the article DOI: 10.1089/aivt.2019.0005.]. Copyright 2021, Mary Ann Liebert, Inc., publishers.
Published Erratum
Applied in vitro toxicology. 2021 Mar 1;7(1):34. DOI:10.1089/aivt.2019.0005.correx 2021
Nitric Oxide Regulates Macrophage Fungicidal Activity via S-nitrosylation of Dectin-1 [0.03%]
一氧化氮通过修饰Dectin-1来调节巨噬细胞的抗真菌活性
James Gow,Yujie Yang,Mohan Govindraj et al.
James Gow et al.
Introduction: Recognition of fungal surface β-glucan by pattern recognition receptor Dectin-1 is a critical process for fungal clearance in the lung. In humans, persistent fungal infection is observed in individuals with particular Dectin-...
Air-Liquid Interface In Vitro Models for Respiratory Toxicology Research: Consensus Workshop and Recommendations [0.03%]
用于呼吸毒理学研究的空气-液体界面体外模型：共识研讨会与建议
Ghislaine Lacroix,Wolfgang Koch,Detlef Ritter et al.
Ghislaine Lacroix et al.
In vitro air-liquid interface (ALI) cell culture models can potentially be used to assess inhalation toxicology endpoints and are usually considered, in terms of relevancy, between classic (i.e., submerged) in vitro models and animal-based ...