DNA Repair Processes and Checkpoint Pathways in Human Cells Exposed to Heavy Ion Beams [0.03%]
重离子束照射的人类细胞中的DNA修复过程和检查点途径
Hirohiko Yajima,Lian Xue
Hirohiko Yajima
The DNA double-strand break (DSB) is the most deleterious of the ionizing radiation-induced DNA damages. Two major repair pathways for DSBs have been well studied, nonhomologous end-joining and homologous recombination. It is known that hig...
New Ions for Therapy [0.03%]
用于治疗的新离子技术
Francesco Tommasino,Emanuele Scifoni,Marco Durante
Francesco Tommasino
Purpose: Charged particle therapy (CPT) is currently based on the use of protons or carbon ions for the treatment of deep-seated and/or radioresistant tumors, which are known to return poor prognosis in photon treatments....
An Introduction to the International Journal of Particle Therapy's Special Issue on Carbon Therapy [0.03%]
国际粒子疗法杂志关于碳离子治疗专题介绍
Nancy P Mendenhall
Nancy P Mendenhall
Interplay Effect of Target Motion and Pencil-Beam Scanning in Proton Therapy for Pediatric Patients [0.03%]
儿童患者质子治疗中 pencil-beam 扫描与靶区运动的交互作用的影响研究
Andrew J Boria,Jinsoo Uh,Fakhriddin Pirlepesov et al.
Andrew J Boria et al.
Purpose: To investigate the effect of interplay between spot-scanning proton beams and respiration-induced tumor motion on internal target volume coverage for pediatric patients. ...
Sally A Amundson
Sally A Amundson
Proton therapy for cancer is now in widespread use, and facilities for carbon ion therapy are showing great promise, but a more complete understanding of the mechanisms underlying particle radiation therapy is still needed in order to optim...
Radiogenomic Predictors of Adverse Effects following Charged Particle Therapy [0.03%]
辐射基因组学预测粒子治疗后的不良反应
Lindsay M Morton,Luisel Ricks-Santi,Catharine M L West et al.
Lindsay M Morton et al.
Radiogenomics is the study of genomic factors that are associated with response to radiation therapy. In recent years, progress has been made toward identifying genetic risk factors linked with late radiation-induced adverse effects. These ...
Developing Predictive or Prognostic Biomarkers for Charged Particle Radiotherapy [0.03%]
重粒子放射治疗的预测或预后生物标志物的研发
Michael D Story,Jing Wang
Michael D Story
The response to radiotherapy can vary greatly among individuals, even though advances in technology allow for the highly localized placement of therapeutic doses of radiation to a tumor. This variability in patient response to radiation is ...
Harald Paganetti
Harald Paganetti
Proton therapy treatments are prescribed using a biological effectiveness relative to photon therapy of 1.1, that is, proton beams are considered to be 10% more biologically effective. Debate is ongoing as to whether this practice needs to ...
RBE Model-Based Biological Dose Optimization for Proton Radiobiology Studies [0.03%]
基于RBE模型的生物剂量优化在质子放射生物学研究中的应用
Fada Guan,Changran Geng,Duo Ma et al.
Fada Guan et al.
Purpose: The purpose of the current study was (1) to develop a straightforward and rapid method to incorporate a dose-averaged linear energy transfer (LET d )-based biological effect model into a dose optimization algorit...
The Relative Biological Effect of Spread-Out Bragg Peak Protons in Sensitive and Resistant Tumor Cells [0.03%]
剂量分布展宽布拉格峰质子束对敏感和抗药肿瘤细胞的相对生物效应研究
Yu-Fen Lin,Benjamin P Chen,Wende Li et al.
Yu-Fen Lin et al.
Purpose: Variations in the radiosensitivity of tumor cells within and between tumors impact tumor response to radiation, including the dose required to achieve permanent local tumor control. The increased expression of DN...