Angel J Rubio,Xuemei Zhong,Tyrone M Porter
Angel J Rubio
The recent emergence of immunotherapies is transforming cancer treatments. Although many cancer immunotherapies are finding enormous success for treating hematologic tumors, a major obstacle for the treatment of solid tumors is localizing i...
The Cardiopulmonary Effects of Sodium Fluoroacetate (1080) in Sprague-Dawley Rats [0.03%]
氟乙酸钠(1080)对Sprague-Dawley大鼠心肺功能的影响
Bryan J McCranor,Talearia D Young,Justin Tressler et al.
Bryan J McCranor et al.
Sodium fluoroacetate (1080) is a highly toxic metabolic poison that has the potential because of its lack of defined color, odor, and taste and its high water solubility to be intentionally or unintentionally ingested through food adulterat...
New Evidence for the Diversity of Mechanisms and Protonated Schiff Bases Formed in the Non-Enzymatic Covalent Protein Modification (NECPM) of HbA by the Hydrate and Aldehydic Forms of Acetaldehyde and Glyceraldehyde [0.03%]
乙二醛和甘油醛的水合物及醛形式非酶促共价修饰HbA（NECPM）作用机制多样性的新证据及形成的质子化Schiff碱
Justin Lewis,Brandy A Smith,Heaton Oakes et al.
Justin Lewis et al.
Acetaldehyde is a physiological species existing in blood. Glyceraldehyde is a commonly-used surrogate for glucose in studies of nonenzymatic glycation. Both species exist in dynamic equilibrium between two forms, an aldehyde and a hydrate....
Potential roles of inorganic phosphate on the progression of initially bound glucopyranose toward the nonenzymatic glycation of human hemoglobin: mechanistic diversity and impacts on site selectivity [0.03%]
无机磷酸对葡萄糖早期结合阶段非酶促糖基化人血红蛋白进展的潜在作用：机制多样性及位点选择性影响
Brandy A Smith,Christina R Mottishaw,Andria J Hendricks et al.
Brandy A Smith et al.
Nonenzymatic glycation (NEG) begins with the non-covalent binding of a glucopyranose to a protein. The bound glucopyranose must then undergo structural modification to generate a bound electrophile that can reversibly form a Schiff base, wh...
Marie K Holt,Stefan Trapp
Marie K Holt
Glucagon-like peptide-1 (GLP-1) within the brain is a potent regulator of food intake and most studies have investigated the anorexic effects of central GLP-1. A range of brain regions have now been found to be involved in GLP-1 mediated an...