PPARδ and PGE2 signaling pathways communicate and connect inflammation to colorectal cancer [0.03%]
PPARδ和PGE2信号通路的相互作用及其在炎症介导结直肠癌发生中的功能连接研究
Dingzhi Wang,Raymond N DuBois
Dingzhi Wang
The nuclear hormone receptor peroxisome proliferator-activated receptor δ (PPARδ) is a ligand-dependent transcription factor that is involved in fatty acid metabolism, obesity, wound healing, inflammation, and cancer. Despite decades of r...
Chronic sustained inflammation links to left ventricular hypertrophy and aortic valve sclerosis: a new link between S100/RAGE and FGF23 [0.03%]
慢性持续性炎症与左心室肥大和主动脉瓣钙化相关：S100/RAGE与FGF23之间新的关联标志物
Ling Yan,Marion A Hofmann Bowman
Ling Yan
Background: Cardiovascular disease including left ventricular hypertrophy, diastolic dysfunction and ectopic valvular calcification are common in patients with chronic kidney disease (CKD). Both S100A12 and fibroblast gro...
Significance of arachidonic acid in ocular infections and inflammation [0.03%]
花生四烯酸在眼部感染和炎症中的作用意义分析
Trivendra Tripathi,Hassan Alizadeh
Trivendra Tripathi
Innate immune responses in the cornea mainly play an important role to mobilize multiple interrelated pathways of corneal lipid, which involve in inflammatory corneal diseases. Signaling lipid mediators derived from arachidonic acid (AA) co...
Cbl-b: Roles in T Cell Tolerance, Proallergic T Cell Development, and Cancer Immunity [0.03%]
Cbl-b在T细胞耐受、促过敏T细胞发育和抗癌免疫中的作用
Jian Zhang,Qingjun Liu,Wallace Y Langdon
Jian Zhang
Cbl-b is a member of the Cbl family of RING finger E3 ubiquitin ligases and polymorphisms and mutations in Cbl-b are associated with several autoimmune/inflammatory diseases in humans. Furthermore, gene targeting experiments in mice have pr...
George Hajishengallis
George Hajishengallis
Although the glycoprotein MFG-E8 (milk fat globule-epidermal growth factor-factor 8) has been investigated extensively as an anti-inflammatory and homeostatic molecule, a possible role in bone homeostasis and disease was not addressed until...
Monoamine oxidase A (MAO-A): a signature marker of alternatively activated monocytes/macrophages [0.03%]
单胺氧化酶A(MAO-A)：另类活化单核细胞/巨噬细胞的标志性蛋白
Martha K Cathcart,Ashish Bhattacharjee
Martha K Cathcart
Monocytes/macrophages are versatile cells centrally involved in host defense and immunity. Th1 cytokines induce a classical activation program in monocytes/macrophages leading to a proinflammatory M1 macrophage phenotype while Th2 cytokines...
Jamison J Grailer,Peter A Ward
Jamison J Grailer
Despite decades of research, acute respiratory distress syndrome (ARDS) remains an important clinical challenge due to an incomplete understanding of the pathophysiological mechanisms. No FDA-approved drug therapy currently exists for treat...
Suppression of NF-κB signaling mitigates polyethylene wear particle-induced inflammatory response [0.03%]
NF-κB信号的抑制减轻了聚乙烯磨损颗粒诱发的炎症反应
Tzu-Hua Lin,Stuart B Goodman
Tzu-Hua Lin
In end-stage arthritis patients, total joint replacement is a very effective surgical procedure. Nevertheless, the high revision rate after surgery remains a major concern. The wear particles generated from biomaterial-induced tissue respon...
Geeta Ramesh
Geeta Ramesh
There is abounding evidence that neuroinflammation plays a major role in the pathogenesis of neurodegeneration and neuropathic pain. Chemokine-induced recruitment of peripheral immune cells is a central feature in inflammatory neurodegenera...
Bacterial lipopolysaccharide induces a dose-dependent activation of neuroglia and loss of basal forebrain cholinergic cells in the rat brain [0.03%]
细菌脂多糖诱导大鼠脑基底前脑胆碱能细胞的剂量依赖性激活和丢失
Heidi M Houdek,Jordan Larson,John A Watt et al.
Heidi M Houdek et al.
In a rat model of neuroinflammation induced with a low-dose infusion lipopolysaccharide (5.0 ng/hr, LPS), we reported that brain arachidonic acid (ARA, 20:4 n-6), but not docosahexaenoic acid (DHA, 22:6n-3), metabolism is increased compared...