Antacid therapy and disease outcomes in idiopathic pulmonary fibrosis: flip side of the story [0.03%]
特发性肺纤维化患者抑酸治疗与疾病预后的关联研究——另一面的故事
Yohannes T Ghebre
Yohannes T Ghebre
RNA N6-adenosine methylation (m6A) steers epitranscriptomic control of herpesvirus replication [0.03%]
N6-腺苷甲基化(m6A)引导病毒复制的表转录组学调控
Fengchun Ye
Fengchun Ye
Latency is a hallmark of all herpesviruses, during which the viral genomes are silenced through DNA methylation and suppressive histone modifications. When latent herpesviruses reactivate to undergo productive lytic replication, the suppres...
Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury [0.03%]
胆汁淤积性肝损伤时胆酸致肝脏炎症机制的研究
Shi-Ying Cai,James L Boyer
Shi-Ying Cai
The mechanism of bile acid induced cholestatic liver injury remains controversial, thus hindering the development of new therapies for these diseases. In this research highlight, we briefly review the evolution of our understanding of the p...
Aryl hydrocarbon receptor signaling involves in the human intestinal ILC3/ILC1 conversion in the inflamed terminal ileum of Crohn's disease patients [0.03%]
芳香烃受体信号在克罗恩病远端回肠炎症中调控肠驻留天然淋巴细胞互换转换
Jian Li,Andria Doty,Sarah C Glover
Jian Li
Innate lymphoid cells (ILCs) are emerging as important components of our immune system that have critical effector and regulatory functions in both innate and adaptive immune responses. They are enriched at mucosal surfaces, such as lung an...
Blood borne: bacterial components in mother's blood influence fetal development [0.03%]
母体血液中的细菌成分影响胎儿发育
Allister J Loughran,Elaine I Tuomanen
Allister J Loughran
Bacterial or viral infection of the mother during the course of pregnancy can cross the placenta and actively infect the fetus. However, especially for bacteria, it is more common for mothers to experience an infection that can be treated w...
RIGulation of STING expression: at the crossroads of viral RNA and DNA sensing pathways [0.03%]
STING表达的调控：病毒RNA和DNA感受通路的交汇点
Yiliu Liu,Rongtuan Lin,David Olagnier
Yiliu Liu
The innate immune sensing of pathogens is important for host to mount defensive responses. STING has emerged in recent years as a critical signaling adaptor in the immune response to cytosolic DNA and RNA derived from pathogens. Liu et al. ...
The role of C-reactive protein in innate and acquired inflammation: new perspectives [0.03%]
C反应蛋白在固有免疫和获得性免疫中的作用：新观点
JoAnn Trial,Lawrence A Potempa,Mark L Entman
JoAnn Trial
The participation of C-reactive protein (CRP) in host defense against microorganisms has been well described. More controversial has been its role in chronic conditions such as cardiovascular disease. Our recent publications explain the rea...
Asynchronous inflammation and myogenic cell migration limit muscle tissue regeneration mediated by a cellular scaffolds [0.03%]
异步炎症和肌原性细胞迁移限制由细胞支架介导的肌肉组织再生
Koyal Garg,Catherine L Ward,Benjamin T Corona
Koyal Garg
Volumetric muscle loss (VML) following orthopaedic trauma results in chronic loss of strength and can contribute to disability. Tissue engineering and regenerative medicine approaches to regenerate the lost skeletal muscle and improve funct...
Bilirubin acts as an endogenous regulator of inflammation by disrupting adhesion molecule-mediated leukocyte migration [0.03%]
胆红素通过破坏粘附分子介导的白细胞迁移，充当炎症内源性调节因子的作用
Megan E Vogel,Stephen D Zucker
Megan E Vogel
There is a growing body of evidence that bilirubin, which is generated during the physiological breakdown of heme, exerts potent anti-inflammatory effects. Previous work by our group suggests that bilirubin is able to suppress inflammatory ...
The parasitic worm product ES-62 up-regulates IL-22 production by γδ T cells in the murine model of Collagen-Induced Arthritis [0.03%]
寄生虫产品ES-62通过小鼠自身免疫性疾病 collagen-induced arthritis(CIA) 模型中的γδT细胞上调IL-22的产生
Margaret M Harnett,William Harnett,Miguel A Pineda
Margaret M Harnett
ES-62 is a phosphorylcholine (PC)-containing glycoprotein secreted by the filarial nematode Acanthocheilonema viteae that acts to modulate the host immune response to promote the establishment of chronic helminth infection. Reflecting its a...