Mini-review: androgen receptor phosphorylation in prostate cancer [0.03%]
mini review：前列腺癌中的雄激素受体磷酸化
Garrett Daniels,Zhiheng Pei,Susan K Logan et al.
Garrett Daniels et al.
Androgen receptor (AR) plays an important role in the tumorigenesis and progression of prostate cancer (PCa), and is the primary therapeutic target for PCa treatment. AR activity can be regulated via phosphorylation at multiple phosphorylat...
Haitao Zhang,Yang Zhan,Xichun Liu et al.
Haitao Zhang et al.
Significant advances in our understanding of continued androgen receptor (AR) signaling in castration-resistant prostate cancer have led to the development and FDA approval of two next-generation androgen-directed therapies, abiraterone and...
Alessandro Sciarra,Vincenzo Gentile,Valeria Panebianco
Alessandro Sciarra
Background: A Prostate Cancer Unit is a place where men can be cared for by specialists in prostate cancer (PC), working together within a multi-disciplinary team (MDT). The MDT approach guarantees a higher probability fo...
Martha K Terris,Zhou Wang,Zoran Culig et al.
Martha K Terris et al.
Metastasis as a therapeutic target in prostate cancer: a conceptual framework [0.03%]
转移作为前列腺癌的治疗靶点：一个概念框架
Konstantin Stoletov,David Bond,Katie Hebron et al.
Konstantin Stoletov et al.
Metastasis is the main cause of prostate cancer-associated deaths. While significant progerss has been made in the treatment of primary tumors, efficent therapies that target the metastatic spread of prostate cancer are far from clinical re...
Wnt signaling in castration-resistant prostate cancer: implications for therapy [0.03%]
前列腺癌去势抵抗中的Wnt信号传导及其治疗意义
Noriko N Yokoyama,Shujuan Shao,Bang H Hoang et al.
Noriko N Yokoyama et al.
Increasing evidence has indicated that Wnt signaling plays complex roles in castration resistant prostate cancer (CRPC). Although not all data were consistent, β-catenin nuclear localization and its co-localization with androgen receptor (...
Mini-review: perspective of the microbiome in the pathogenesis of urothelial carcinoma [0.03%]
小型综述：泌尿上皮细胞癌发病机制中微生物群的视角
Weisheng Xu,Liying Yang,Peng Lee et al.
Weisheng Xu et al.
The microbiome is a new center of attention for studies on the pathogenesis of human disease by focusing on the alterations of all microorganisms living in a particular site or system of human body, referred as microbiota. Evidence suggests...
Karen S Sfanos,William B Isaacs,Angelo M De Marzo
Karen S Sfanos
The frequent observation of both acute and chronic inflammation of unknown stimulus in the adult prostate has motivated a large body of research aimed at identifying potential infectious agents that may elicit prostatic inflammation. The ov...
Construction and evaluation of a prognostic model for metabolism-related genes in kidney renal clear cell carcinoma using TCGA database [0.03%]
基于TCGA数据库构建并评估代谢相关基因在肾透明细胞癌中预后价值的模型研究
Objective: To investigate the expression of metabolism-related genes (MRGs) in kidney renal clear cell carcinoma (KIRC) and their association with patient prognosis, and to identify potential targets for intervention. ...
Next-generation sequencing identifies the presence of protein phosphatase 1D, PPM1D, as a potential biomarker of resistance to PARP inhibition in metastatic castration-resistant prostate cancer [0.03%]
下一代测序鉴定蛋白磷酸酶1D（PPM1D）为转移性去势抵抗性前列腺癌对PARP抑制产生抗性的潜在生物标志物
The landscape for the treatment of advanced and metastatic prostate cancer is rapidly changing. For patients with metastatic castration-resistant prostate cancer (mCRPC), next-generation sequencing (NGS) may identify those with Homologous R...