Scanning the Horizon of Sociogenomics: an Assessment of the Development and Growth of Polygenic Indices for Social and Behavioral Traits [0.03%]
社会基因组学的前景扫描：多基因指标在社会和行为特征的发展和增长评估中应用综述
Courtney Canter,Karen M Meagher,R Jean Cadigan et al.
Courtney Canter et al.
Background: Increasingly, researchers are leveraging social science survey data and genomic samples from millions of biobank participants to develop polygenic indices (PGIs) for social and behavioral traits. ...
Megan M Shen,Justin T Clapp,Holly Fernandez Lynch et al.
Megan M Shen et al.
Background: A number of patient organizations have recently embraced venture philanthropy, a model of patient advocacy that purports to use practices from venture capitalism in pursuit of philanthropic goals. However, a c...
Whose Autonomy Matters? Using Relational Autonomy to Analyze Caregiver Roles in Decision-Making for Cancer Clinical Trials [0.03%]
谁的自主权重要？利用关系自主权分析癌症临床试验中决策者的角色
Eric C Blackstone,Susan R Mazanec,Barbara J Daly et al.
Eric C Blackstone et al.
Background: Participation in a therapeutic clinical trial can be a challenging decision for patients with cancer and their family caregivers. Despite the implications of clinical trials for caregivers, there is little emp...
Alzheimer's Disease Clinical Trial Decision-Making Among Patients with Mild Cognitive Impairment and Their Study Partners [0.03%]
轻度认知障碍患者及其研究伙伴在阿尔茨海默病临床试验决策中的作用
Chelsea G Cox,Adam I Birnbaum,Christian R Salazar et al.
Chelsea G Cox et al.
Background. Prodromal Alzheimer's disease (AD) clinical trials enroll patients with mild cognitive impairment (MCI) and their study partners. This study examined trial enrollment decision-making and risk for misunderstanding trial informati...
Medical Sanctions and the Response of Pharmaceutical Companies to Russia's Invasion of Ukraine: A Thematic Analysis [0.03%]
医疗制裁与医药公司对俄罗斯入侵乌克兰的反应：主题分析
Christopher A Bobier,Krisha Darji,Daniel J Hurst
Christopher A Bobier
Introduction: The 2022 Russian invasion of Ukraine prompted diverse responses from global corporations. This study investigates the perspectives and actions of leading pharmaceutical companies amidst this geopolitical cri...
Informed Consent Documents from Psychedelic Clinical Trials: A Descriptive Ethical Analysis [0.03%]
来自迷幻药物临床试验的知情同意文件：描述性伦理分析
Katherine Cheung,Caleigh Propes,Marianna Graziosi et al.
Katherine Cheung et al.
Background: Classic psychedelics, such as psilocybin and LSD, evoke certain kinds of altered states of consciousness. Specific features of the experience, such as its allegedly ineffable nature, have been discussed as pos...
Nyiramugisha Niyibizi,Tekiah McClary,Margie Dixon et al.
Nyiramugisha Niyibizi et al.
Background: Clinical trials of medical therapies are critical for the advancement of care and are expensive. Sometimes, the costs of study drugs are not covered by insurance or the sponsor, and trial participants bear the...
Pediatric Intensivists' Perspectives on Nudging: A Multi-Institution Assessment of Ethical Permissibility [0.03%]
儿科医生关于推动的看法：伦理许可的多机构评估
Aliza M Olive,Asdis Finnsdottir Wagner,Ashely K Sherman et al.
Aliza M Olive et al.
Background: Nudging is a behavioral economics concept that describes subtle influences on decisions without restricting options or altering incentives. Though commonly studied in public health, the ethical implications in...
Development and Validation of a Stakeholder-Driven, Self-Contained Electronic Informed Consent Platform for Trio-Based Genomic Research Studies [0.03%]
一种基于利益相关者驱动、自包含的电子知情同意平台的发展与验证用于基于家系的基因组研究项目
Bethany Y Norton,James Liu,Sara A Lewis et al.
Bethany Y Norton et al.
Background: Increasingly long and complex informed consents have yielded studies demonstrating comparatively low participant understanding and satisfaction with traditional face-to-face approaches. In parallel, interest i...
Should Physicians Take the Rap? Normative Analysis of Clinician Perspectives on Responsible Use of 'Black Box' AI Tools [0.03%]
医师是否应该承担责任？规范分析临床医生对“黑盒”AI工具负责任使用的态度观点
Ben H Lang,Kristin Kostick-Quenet,Jared N Smith et al.
Ben H Lang et al.
Background: Increasing interest in deploying artificial intelligence tools in clinical contexts has raised several ethical questions of both normative and empirical interest. One such question in the literature is whether...