Evaluation of the MEFIER Score in Identifying Patients at High Risk of Endocarditis in Enterococcus faecalis Bacteremia [0.03%]
评估MEFIERS评分在识别肠球菌菌血症患者感染性心内膜炎高风险中的价值
Virgile Zimmermann,Nicolas Fourré,Pierre Monney et al.
Virgile Zimmermann et al.
In a retrospective cohort of 549 Enterococcus faecalis bacteremia episodes, the MEFIER score showed poor rule-out performance (negative likelihood ratio of 0.69), misclassifying 60% of IE episodes as low-risk. In contrast, DENOVi score achi...
Data-driven Modeling of Long-term CD4 Cell Recovery Trajectories Under Modern Antiretroviral Therapy in People Living With HIV [0.03%]
基于现代抗逆转录病毒治疗的HIV感染者的长期CD4细胞恢复轨迹的数据驱动模型
You Ge,Chunqin Bai,Anni Liu et al.
You Ge et al.
Background: Although CD4 recovery has been widely studied, its long-term temporal dynamics and phase-specific characteristics in the modern ART era remain incompletely characterized. ...
Gastric Aspirate Isolate Demonstrates Strain-Level Concordance With Sputum Isolate in Nontuberculous Mycobacterial Pulmonary Disease [0.03%]
胃吸出物分离株与非结核分枝杆菌肺病患者的痰分离株菌株一致
Atsushi Funauchi,Kazuki Hashimoto,Kiyoharu Fukushima et al.
Atsushi Funauchi et al.
The nontuberculous mycobacteria (NTM) isolated from gastric aspirate have demonstrated >85% strain concordance with those from the sputum, suggesting that they originate from the lungs rather than the environment. Gastric aspirate, although...
Age-specific Risk of Herpes Zoster in Immunocompetent Adults ≥18 Years-of-age-A Retrospective Cohort Study in the United States [0.03%]
美国18岁及以上免疫功能正常成人单纯疱疹风险的年龄特异性研究——一项基于回顾性队列的研究
Rachel A Cohen,Driss Oraichi,Agnes Mwakingwe-Omari et al.
Rachel A Cohen et al.
Background: Approximately one-third of United States (US) individuals develop herpes zoster (HZ). Recent HZ incidence data are lacking, especially in immunocompetent adults 18-49 years-of-age (YoA). Recombinant HZ vaccine...
The Impact of Adopting Whole-Genome Sequencing for Tuberculosis Diagnosis in China: A Cost-Effectiveness Analysis [0.03%]
在中国采用全基因组测序进行结核病诊断的影响：成本效益分析
Yibei He,Xuanjing Li,Chang Liu et al.
Yibei He et al.
Background: China is a high-burden tuberculosis (TB) country and delays in diagnosis and effective treatment have further exacerbated this situation. Whole-genome sequencing (WGS) has emerged as a reliable approach for dr...
Performance of Laboratory Testing in Culture-Confirmed Blastomycosis: A Retrospective Study [0.03%]
实验室检验在培养确认的芽生菌病中的表现：一项回顾性研究
Janiece Glover,Lili Tao
Janiece Glover
This retrospective study evaluated diagnostic modalities in 51 culture-confirmed blastomycosis cases over a 10-year period. Urine antigen testing demonstrated variable sensitivity across disease types, whereas antibody testing with enzyme i...
Exploring Early Antifungal Activity of Rezafungin as a Stepping-Stone for Shorter Treatment Duration for Candidemia: Pooled Analysis of 2 Randomized Trials [0.03%]
达肝素治疗念珠菌血症早期抗真菌活性探索：两项随机试验的汇总分析
Luis Ostrosky-Zeichner,Jalal A Aram,Mark Redell et al.
Luis Ostrosky-Zeichner et al.
Background: Guidelines recommend ≥2 weeks of antifungal therapy after candidemia clearance and for invasive candidiasis (IC). This post-hoc analysis evaluates Day 7 pooled data from the phase 2 STRIVE and phase 3 ReSTORE...
Serum Biomarkers of Macrophage Activation and Incident CKD in People With and Without HIV: Findings From the MACS-WIHS Combined Cohort Study [0.03%]
HIV阳性和阴性人群血清巨噬细胞活化生物标志物与CKD发病：来自MACS-WIHS联合队列研究的结果
Molly C Fisher,David B Hanna,Donald R Hoover et al.
Molly C Fisher et al.
Background: Macrophages play an important role in kidney inflammation and fibrosis. Circulating biomarkers of macrophage activation are elevated in people with HIV (PWH). We therefore determined their associations with ki...
Frontline Febrile Neutropenia Antibiotic Treatment Across Institution Types: A Multicenter Survey Study [0.03%]
一项多中心调查研究：各类机构前线发热性中性粒细胞减少症抗生素治疗状况
Maia Castillo,Derick Gross,Stephanie J Harding
Maia Castillo
The inherently variable nature of febrile neutropenia contributes to inconsistent adherence to Infectious Diseases Society of America/American Society of Clinical Oncology guidelines. This survey collected information on how institutions tr...
Containment of a Multi-index B.1.1.7 Outbreak on a University Campus Through a Genomically Informed Public Health Response [0.03%]
通过基于基因组的公共卫生应对措施遏制大学校园内的B.1.1.7多例感染群集事件
Emily T Martin,Adam S Lauring,JoLynn P Montgomery et al.
Emily T Martin et al.
Increasing the precision of outbreak containment for emerging virus strains requires real-time virus identification that can be integrated with specific public health actions. During the SARS-CoV-2 pandemic, we established a multisector par...