Evaluation of Real-World Antiviral Effectiveness and Sustainability of the 2-Drug Regimen Dolutegravir/Lamivudine Fixed-Dose Combination in Treatment-Naive and Pretreated People Living With HIV Who are Virologically Suppressed, in Routine Clinical Care in France: Results From the CARAVEL Study [0.03%]
法国日常医疗保健中卡拉夫研究评估了初治和经治并已病毒学抑制的HIV感染者的二线疗法拉米夫定多替拉韦片抗病毒疗效及耐药性：二联复方制剂治疗的临床效果
Patrick Philibert,Charlotte Charpentier,Nilakshani Naguleswaran et al.
Patrick Philibert et al.
Background: Despite demonstrated virological efficacy, real-world evidence on the long-term effectiveness of dolutegravir plus lamivudine (DTG/3TC) in people living with HIV (PLWH) remains limited; this study assessed eff...
Thiazolidinedione Use and Risk of Bacterial Enteric Infection Among Adults With Type 2 Diabetes Mellitus [0.03%]
噻唑烷二酮类药物的使用与2型糖尿病成人肠道细菌感染风险的关系
Morgan Birabaharan,David C Kaelber,Victor Nizet et al.
Morgan Birabaharan et al.
Background: Thiazolidinediones are peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists commonly used to treat type 2 diabetes mellitus. In experimental models, epithelial PPAR-γ signaling contributes to colo...
Chagas-specific Death and Competing Risk of Mortality in Chile: A Nationwide Retrospective Cohort Study, 2007-2021 [0.03%]
2007年至2021年智利全国查加斯病特异性死亡及总死亡率竞争风险的回顾性队列研究
Franco Fernández-Guardiola,Claudia T Codeço,Natalia Vergara et al.
Franco Fernández-Guardiola et al.
Background: Chagas disease (CD) in Chile has shifted toward a postvector-control, aging-cohort scenario in which chronic sequelae increasingly shape outcomes. We quantified Chagas-specific mortality and associated factors...
Outpatient Management of Imported Nonsevere Falciparum Malaria in Adults in the United Kingdom: A Multisite Evaluation of Clinical Safety and Costing Analysis [0.03%]
英国成人输入性恶性疟非重症门诊治疗的临床安全性及成本分析多中心评估研究
James Milburn,Anne Williamson,Sneha Baljekar et al.
James Milburn et al.
Background: Imported falciparum malaria represents a significant health care burden disproportionate to its incidence. UK guidelines have traditionally recommended admission for all cases of nonsevere falciparum malaria. ...
A Randomized, Double-Blind Clinical Trial of One vs Two Doses of High-Dose Influenza Vaccine in Solid Organ Transplant Recipients [0.03%]
单剂与双剂高剂量流感疫苗在器官移植受者中效果的随机双盲临床试验
Kevin Escandón,Sophia Q Tang,Jamie Forschmiedt et al.
Kevin Escandón et al.
Background: Solid organ transplant recipients (SOTRs) exhibit suboptimal immune responses to standard-dose influenza vaccines. High-dose (HD) vaccines and booster strategies show promise, but the optimal vaccination appro...
A French National Real-World Survey of People With Multiresistant HIV-1 Viruses Receiving an Antiretroviral Regimen Including Fostemsavir or Ibalizumab [0.03%]
法国一项针对接受福沙匹韦或艾博维昔拉抗逆转录病毒治疗的多重耐药HIV-1患者的全国真实世界调查
Karl Stefic,Camille Tumiotto,Anne de Monte et al.
Karl Stefic et al.
Background: Attachment inhibitor fostemsavir (FTR) and postattachment inhibitor ibalizumab (IBA) are used in people with HIV-1 (PWH) who are highly treatment experienced and harboring multidrug-resistant viruses, and real...
Influenza Vaccine Effectiveness Against Influenza-Associated Hospitalizations and Emergency Department or Urgent Care Encounters Among Children and Adults-VISION, United States, 2024-2025 Season [0.03%]
2024-2025年季节性流感疫苗在儿童和成人中预防住院和急诊或门诊就诊的有效性——美国VISION项目数据
Jennifer DeCuir,Emily L Reeves,Zachary A Weber et al.
Jennifer DeCuir et al.
Background: The 2024-2025 influenza season was the most severe in the United States (US) since 2017-2018, with co-circulation of both influenza A virus subtypes (H1N1 and H3N2). Influenza vaccine effectiveness (VE) has va...
Single-dose Ceftriaxone Plus 7-Day Doxycycline Versus Single-dose Benzathine Penicillin G Plus 7-Day Doxycycline in the Treatment of Early Syphilis in People With HIV: a Pilot Randomized Noninferiority Trial [0.03%]
单剂量头孢曲松联合7天多西环素与单剂量苄星青霉素联合7天多西环素治疗HIV感染早期梅毒患者：一项试点随机非劣效性试验
Tzong-Yow Wu,Kuan-Yin Lin,Hsin-Yun Sun et al.
Tzong-Yow Wu et al.
Background: Both ceftriaxone (CRO) and doxycycline demonstrate activity against Treponema pallidum and bacteria causing sexually transmitted infections (STIs); however, the efficacy of their combination in a shorter durat...
An Exploratory Study of Host Plasma Proteomic Signatures that Distinguish Secondary and Early Latent Syphilis in Adults [0.03%]
成人继发梅毒和早期潜伏梅毒宿主血浆蛋白组特征的探索性研究
Cody Chou,Shad R Morton,Kelika A Konda et al.
Cody Chou et al.
Syphilis diagnostics struggle to distinguish active from treated disease. Using tandem-mass-tag proteomics on plasma from 10 secondary and early latent syphilis cases and 8 matched controls, we identified 54 differentially regulated protein...
Epidemiology and Risk Factors for Infection in Multiple Myeloma Patients Treated With Bispecific Antibodies [0.03%]
双特异性抗体治疗多发性骨髓瘤患者的感染流行病学和风险因素
Eduardo Aparicio-Minguijón,Nieves López-Muñoz,Guillermo Bartolomé Herguedas et al.
Eduardo Aparicio-Minguijón et al.
Background: Bispecific antibodies (BsAbs) have revolutionized multiple myeloma (MM) treatment but are associated with infectious complications. This study aims to characterize the incidence, microbiological patterns, and ...