Integrating Precision Sepsis Risk Stratification Into Systems-Based Antimicrobial Stewardship [0.03%]
基于系统的抗菌药物管理中整合精确的脓毒症风险分层
James S Ford,Shamim Nemati,Ben Gross et al.
James S Ford et al.
Early broad-spectrum antimicrobial administration in sepsis is strongly associated with improved survival. However, widespread implementation of time-based antibiotic mandates has substantially increased antimicrobial utilization, contribut...
Assessing Statistical Methods for Estimating the Cerebrospinal Fluid Early Fungicidal Activity as an Endpoint for Cryptococcal Meningitis Clinical Trials: A Systematic Review and Simulation Study [0.03%]
估算脑脊液早期杀菌作用作为隐球菌性脑膜炎临床试验终点的统计方法评价：系统综述与模拟研究
Monica Fuszard,David R Boulware,Biyue Dai
Monica Fuszard
Background: Cryptococcal meningitis is a life-threatening infection of the central nervous system. Early fungicidal activity (EFA), which measures how quickly Cryptococcus yeasts are cleared from cerebrospinal fluid (CSF)...
Clinical Characteristics and Outcomes of Bloodstream Infections Caused by Metallo-β-Lactamase-Producing Enterobacterales in Argentina: A Subanalysis of the EMBARCAR Prospective Multicenter Cohort Study [0.03%]
阿根廷由金属β-内酰胺酶产生的肠杆菌血流感染的临床特点和结局：EMBARCAR前瞻性多中心队列研究中的亚组分析
Ezequiel Cordova,Juan Pablo Balbuena,Analia Mykietiuk et al.
Ezequiel Cordova et al.
Background: Bloodstream infections (BSI) caused by metallo-beta-lactamase (MBL)-producing Enterobacterales (E) are associated with high mortality. However, in most Latin American countries there is a lack of clinical and ...
mRNA and Protein Subunit COVID-19 Vaccine Reactogenicity and Their Relationship to Productivity for Healthcare Workers and First Responders [0.03%]
新冠 mRNA 和蛋白质组分疫苗对中国医护人员和应急人员接种率的影响及其相关性研究
Sarang K Yoon,Andrew L Phillips,Sarah Calhoun et al.
Sarang K Yoon et al.
Objectives: To compare the percentage of participants that experienced any solicited reactogenicity symptom after 1 dose of the updated 2024-2025 adjuvanted protein-based Novavax (NVX; JN.1) or Pfizer-BioNTech mRNA (PFZ; ...
S M Anderson,Z Cing,J L Drewes et al.
S M Anderson et al.
Background: The role of the gut microbiome and specific enteric bacteria in influencing the development of colorectal cancer (CRC) remains incompletely understood. Recently, it was shown that human CRC-derived strains of ...
Acceptability of a Chlamydia Vaccine Among Young Women and Men in Birmingham, Alabama, USA: 2023-2025 [0.03%]
美国阿巴拉契亚地区年轻男女对沙眼衣原体疫苗接受度的研究（2023-2025）
Kanupriya Gupta,Bria I Gamble,Madison J D&#x;Amico et al.
Kanupriya Gupta et al.
Background: Chlamydia infection remains a global health concern, justifying the need for a chlamydia vaccine. Chlamydia infection rates are highest among young women and men; thus, they would be the target populations for...
Impact of High-Dose Rifampicin on Linezolid Pharmacokinetics in Tuberculous Meningitis [0.03%]
高剂量利福平对结核性脑膜炎患者利奈唑胺药代动力学的影响
Dvijen Purohit,Rob van Wijk,Paddy Kafeero et al.
Dvijen Purohit et al.
Background: Tuberculous meningitis (TBM), a severe form of extrapulmonary tuberculosis, requires sustained therapeutic drug concentrations in the central nervous system (CNS). Linezolid is a promising treatment for TBM du...
Similar Changes in Proviral Landscapes Over 10 Years in 40 Individuals With Diverging HIV Reservoir Dynamics and Viral Load Kinetics [0.03%]
40名HIV感染者经过十年不同的病毒库动态和病毒载量变化后其前病毒景观发生类似的改变
Jasmin Tschumi,Lisa Jörimann,Marius Zeeb et al.
Jasmin Tschumi et al.
Background: People with human immunodeficiency virus type 1 (HIV-1; PWH) on antiretroviral therapy (ART) and suppressed viremia usually experience a decrease in HIV DNA over time, but about 25% experience an increase. Som...
Impact of Methicillin-Resistant Staphylococcus aureus Nasal Screening in Lower Respiratory Tract Infections: A Systematic Review Incorporating Network and Bayesian Meta-Analyses [0.03%]
甲氧西林耐药金黄色葡萄球菌鼻部筛查对下呼吸道感染影响的系统评价及网络和贝叶斯Meta分析
Tristan T Timbrook,Zijie Zhang,Tamara Krekel
Tristan T Timbrook
Background: Methicillin-resistant Staphylococcus aureus (MRSA) pneumonia requires empirical therapy coverage for patients with risk factors, yet MRSA causes 99% probability of exceeding minimal clinically important differ...
Effect of the Scale-Up of Dolutegravir on Retention in Care, Risk of Developing Tuberculosis and Viral Load Suppression Among People Living With HIV: Analysis of Routine HIV Clinical Data in Rural KwaZulu-Natal, South Africa (2019-23) [0.03%]
评估扩大使用多替拉韦对生活于农村地区的南非夸祖鲁·纳塔尔人留存医疗体系、结核病发病风险和病毒载量抑制的影响：来自南非夸祖鲁·纳塔尔省的一项基于常规HIV临床数据的研究（2019-23）
Reuben Christopher Moyo,Elphas Okango,Larisse Bolton et al.
Reuben Christopher Moyo et al.
Background: There is limited evidence on how the rollout of dolutegravir (DTG) has affected retention in care, tuberculosis (TB) disease risk, and viral load suppression (VLS) among people living with HIV (PLHIV) in routi...