Intravenous Immunoglobulin Treatment in Patients With Streptococcal Toxic Shock Syndrome in Southern Sweden: A Retrospective Population-Based Study [0.03%]
南瑞典链球菌中毒性休克综合征患者静脉注射免疫球蛋白治疗的回顾性人群研究
Olof Wullt,Charlotta Utbult,Erik Carlson et al.
Olof Wullt et al.
Background: Intravenous immunoglobulins (IVIGs) have been suggested as an adjunctive treatment in streptococcal toxic shock syndrome (STSS), but there are no conclusive trials. In southern Sweden, IVIG is routinely used i...
Risk of Noncommunicable Diseases After Hospitalization for Community-Acquired Pneumonia [0.03%]
社区获得性肺炎住院治疗后的非传染性疾病风险
Julio Ramirez,Stephen Furmanek,Thomas Chandler et al.
Julio Ramirez et al.
Background: Community-acquired pneumonia (CAP) is a leading cause of hospitalization and mortality. Increasing evidence suggests that CAP may contribute to long-term morbidity through the development of noncommunicable di...
Early Combination Antiretroviral Therapy Initiation During Primary HIV Infection Restricts HIV Reservoirs and Gut-Driven Inflammation but Fails to Rewire the Systemic Cytokine Landscape [0.03%]
HIV急性感染早期启动抗逆转录病毒治疗可限制 HIV储存库和肠道驱动的炎症，但无法重构全身细胞因子景观
Valeria Bono,Camilla Tincati,Matteo Augello et al.
Valeria Bono et al.
Background: HIV reservoirs, dysregulated cytokine profile, and gut barrier damage persist despite suppressive combination antiretroviral therapy (cART). Whether initiating cART during primary HIV infection (PHI) mitigates...
Targeted Genomic Surveillance Unveils Genetic Variations Linked to Regional Malaria Drug Resistance Dynamics in India [0.03%]
靶向基因组监测揭示印度区域疟疾药物抗性相关的遗传变异
Ajinkya Khilari,Shweta Sharma,Manali Bajpai et al.
Ajinkya Khilari et al.
Background: India has made substantial progress in reducing Plasmodium falciparum malaria cases and has set a target to eliminate malaria by 2030. Although artemisinin-based combination therapy (ACT) treatment remains eff...
Association Between Low-Dose Ethambutol Therapy and Optic Neuropathy in Mycobacterium avium Complex Pulmonary Disease: A Retrospective Cohort Study Using Propensity Score Analysis [0.03%]
低剂量乙胺丁醇治疗与鸟型分枝杆菌复合体肺病患者的视神经病变相关性研究：倾向性评分匹配的回顾性队列研究
Yasuhiro Morimoto,Hiroki Matsui,Masaki Ikeda et al.
Yasuhiro Morimoto et al.
Background: Current guidelines recommend ethambutol as a first-line agent for treating Mycobacterium avium complex pulmonary disease (MAC-PD) but can induce optic neuropathy. Previous studies suggest that low-dose ethambu...
Factors Involved in Tuberculosis Recurrence in a Low-incidence Setting; Reactivation Predominates Over Reinfection in a 30-year Surveillance Study [0.03%]
低结核病发病率地区复发的危险因素：30年的随访研究发现复燃多于再感染
Xunxiao Lin,Daniel Ibarz,Alberto Cebollada et al.
Xunxiao Lin et al.
Background: Tuberculosis (TB) recurrence remains a significant public health concern, even in regions with low incidence. Recurrent TB may result from endogenous reactivation of a previous infection or from exogenous rein...
A Double-blind Randomized Trial of Oral Chlorhexidine Gluconate for Treatment of Oral Staphylococcus aureus Colonization in Healthy Children [0.03%]
儿童金黄色葡萄球菌携带者的氯己定治疗研究
Lucia Liu,Bryn Launer,Evelyn Flores et al.
Lucia Liu et al.
Background: Staphylococcus aureus is the most common cause of skin and soft tissue infection (SSTI). Nasal S. aureus colonization may precede SSTI, and decolonization may decrease SSTI risk. However, many S. aureus-coloni...
Scalability Metrics and Effort Requirements for a Long-Acting Injectable Antiretroviral Treatment Program [0.03%]
长效抗逆转录病毒注射治疗项目的可扩展性指标及工作要求
Joshua P Havens,Jennifer O&#x;Neill,Maureen Kubat et al.
Joshua P Havens et al.
Implementation of a long-acting injectable antiretroviral treatment program requires substantial multidisciplinary effort, particularly for program coordination, coverage/billing, and patient support/retention. As our program scaled to 113 ...
Syndromic Diagnostics for Travelers' Diarrhea: Near-Patient Field-Expedient Testing in Resource-Limited Settings [0.03%]
旅行者腹泻的综合征诊断：资源有限条件下的现场简便检测方法
Romeo Toriro,Christopher T Williams,Dominic L Wooding et al.
Romeo Toriro et al.
Background: We assessed the diagnostic agreement of BioFire FilmArray multiplex polymerase chain reaction (PCR) with Seegene Allplex PCR for testing fecal samples collected during a diarrhea outbreak in resource-limited s...
AI and the Future of Medical Countermeasures to Protect Against Biological Threats [0.03%]
人工智能与未来医疗反制措施对抗生物威胁
Amesh A Adalja,Jaspreet Pannu,Thomas V Inglesby
Amesh A Adalja