Anna E Whitfield,Julie K Pfeiffer,Terence S Dermody
Anna E Whitfield
A guilty pleasure of ours is having coffee on a Saturday morning with a friend at a neighborhood cafe where the chocolate croissants are divine and the pace of the day is unhurried. We linger longer than intended, cups refilled, as our conv...
The Orthohantavirus GN/GC Spikes: Molecular Determinants of Infection and Targets for Antiviral Immune Interventions [0.03%]
正汉塔病毒GN / GC刺突：感染的分子决定因素及抗病毒免疫干预靶点
Gianina Arata-Salas,Dianne Díaz-Ramírez,Benjamín E Vásquez et al.
Gianina Arata-Salas et al.
Orthohantaviruses are globally distributed, rodent-borne RNA viruses associated with severe and often lethal disease in humans. The documented person-to-person transmission of Andes virus, endemic in South America, underscores their pandemi...
Sonja M Best,Eva Chebishev,Ana Fernández-Sesma
Sonja M Best
Infection with dengue virus (DENV) is a major global public health threat, driven by mosquito transmission of four closely related virus serotypes. For effective transmission between hosts, DENV rapidly remodels the host cell to overcome mu...
Geminivirus-Induced Reprogramming of Plant Defense Mechanisms: Molecular Insights and Research Frontiers [0.03%]
双生病毒诱发的植物防卫机制重编程：分子见解与研究前沿
Namisha Sharma,Susmita Sett,Manoj Prasad
Namisha Sharma
Geminiviruses employ multifunctional protein ammunition to evade robust plant defense pathways. Key viral proteins effectively manipulate host signaling mechanisms to create a permissive environment for viral replication. Rapid evolutionary...
Arun Sankaradoss
Arun Sankaradoss
The evolution of dengue virus (DENV) is highly modulated by pathogen transmission bottlenecks and immunological pressures. These evolutionary events lead to mutations that cause antigenic changes and the replacement of DENV genotypes, which...
Studying the Deep Evolution of Viruses in the Era of Artificial Intelligence Structure Prediction [0.03%]
人工智能结构预测时代的病毒深度进化研究
Spyros Lytras,Mahan Ghafari,Joe Grove
Spyros Lytras
High mutation rates erode viral sequence similarity, obscuring deep evolutionary history. While protein structure is far more conserved than sequence, its use in evolutionary studies has historically been bottlenecked by experimental determ...
Viral Pleomorphism: How Virion Structure Guides Infection and Adaptation [0.03%]
病毒多形性：病毒体结构如何引导感染和适应
Edward A Partlow,Callie J Donahue,Balindile B Motsa et al.
Edward A Partlow et al.
Morphological variability in virion size and shape (pleomorphism) is a prominent feature of many pathogenic enveloped viruses, but understanding its biology presents a long-standing challenge. Understanding the role of pleomorphism in virus...
Dennis L Wright,Sandra K Weller
Dennis L Wright
Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) remain among the most prevalent human pathogens, imposing a substantial global health burden. Recurrent orolabial and genital lesions affect millions worldwide, reflecting lifelong infection ...
Ebba K Blomqvist,James M Burke
Ebba K Blomqvist
Eukaryotic cells compartmentalize critical biomolecular processes within membrane-bound organelles. Within these organelles, nucleic acids and proteins further compartmentalize into distinct structures known as membraneless organelles (MOs)...
Daniel de Castro Assumpção,Danielle Tullman-Ercek,Nolan W Kennedy
Daniel de Castro Assumpção
Viral-inspired materials (VIMs) integrate the nanoscale precision of viral architecture with the versatility of synthetic modification, enabling interfaces that bridge biological and technological systems. This review outlines how surface e...