Immune hallmarks of recurrent immune checkpoint inhibitor-mediated inflammatory arthritis [0.03%]
免疫检查点抑制剂反复引起的炎症性关节炎的免疫特征
Synat Keam,Yuanteng Jeff Li,Yanshuo Chu et al.
Synat Keam et al.
Immune checkpoint inhibitor (ICI) therapy is often associated with immune-related adverse events including inflammatory arthritis (ICI-IA). However, the mechanisms underlying ICI-IA, especially its recurrence, are not well understood. In th...
Periductal Fibroblast Density Defines Lymphocyte Exclusion via a CD44-Dependent Stromal Checkpoint in Pancreatic Cancer [0.03%]
胰腺癌中通过基质检查点调控的CD44依赖性间质成纤维细胞密度决定淋巴细胞浸润屏障
Zoe X Malchiodi,Alexander A Lekan,Robert K Suter et al.
Zoe X Malchiodi et al.
Pancreatic ductal adenocarcinoma (PDAC) exhibits dense fibrosis and immune exclusion. While fibrosis has been studied globally and at the region-of-interest level, its impact on stromal-ductal architecture and immune cell localization remai...
In vitro inhibition of STAT5 signaling limits CD8⁺ T cell exhaustion and improves outcomes in adoptive T-cell therapy [0.03%]
体外抑制STAT5信号可限制CD8⁺T细胞衰竭并改善过继性T细胞治疗的效果
Mitra Shourian,Benoîte Bourdin,Nehme El-Hachem et al.
Mitra Shourian et al.
T cell exhaustion remains a barrier to adoptive cell therapies. Although γc cytokines are used to expand T cells, their impact on T cell states remains incompletely defined. Using an in vitro model of repetitive TCR stimulation, we found t...
The Gut Microbiome Drives Endogenous T Cell Activation Following CAR-T Cell Therapy [0.03%]
CAR-T细胞治疗后的肠道微生物群驱动内源性T细胞活化
Kejia Hu,Lele Jin,Zidan Feng et al.
Kejia Hu et al.
Chimeric antigen receptor (CAR)-T cell therapy has become a promising clinical approach against hematological malignancies, but patients receiving CAR-T cell therapy still presented inconsistent clinical outcomes and are complicated by inco...
CD4+ T cells play distinct roles during the priming versus effector phases of immune checkpoint therapy-dependent tumor elimination by CD8+ T cells [0.03%]
CD4+T细胞在免疫检查点治疗依赖的CD8+t细胞抗肿瘤反应的效应子功能的不同作用阶段
Samuel Ameh,Derek J Theisen,Mahima Thapa et al.
Samuel Ameh et al.
It is well established that CD4⁺ T cells play a critical role in facilitating immune checkpoint therapy (ICT). Although CD4+ T-cell function in lymph nodes during CD8⁺ T-cell priming has been well investigated, their requirement at the ef...
Elevated CHAF1A suppresses type I interferon production and causes immunotherapy resistance in esophageal squamous cell carcinoma [0.03%]
CHAF1A上调抑制I型干扰素产生并导致食管鳞癌免疫治疗耐药性
Yue Ma,Mengde Shi,Ming Ma et al.
Yue Ma et al.
In esophageal squamous cell carcinoma (ESCC), chemoradiotherapy potentiates the effects of immune checkpoint inhibitors (ICIs) by activating the tumor-intrinsic innate immune response. However, ESCC cells frequently suppress this activation...
Tim-3 Sustains Tumor Treg Stability and Function, Limiting Checkpoint Blockade Therapy Efficacy [0.03%]
TIM-3通过维持肿瘤Treg的稳定性和功能限制了免疫检查点阻断疗法的效果
Hridesh Banerjee,Onyedikachi V Onyekachi,Hector Nieves-Rosado et al.
Hridesh Banerjee et al.
Regulatory T cells (Treg) act as a powerful barrier to effective antitumor immunity. Although manipulating Treg is a promising anticancer strategy, doing so while sparing general immune tolerance has been a challenge. Identifying factors sp...
A Patient-Derived Screen Identifies HDAC Inhibitors as Enhancers of Phagocytosis and Potent Immunotherapy Partners [0.03%]
基于患者的筛选鉴定组蛋白去乙酰化酶抑制剂能增强吞噬作用并可成为有效的免疫治疗药物
Mona Khalaj,Andrew T Burden,Madison L Gutierrez et al.
Mona Khalaj et al.
Glioblastoma multiforme (GBM) is a lethal brain tumor with limited treatment options. Tumor-associated macrophages and microglia (TAMs) drive immune suppression and tumor progression, making them a key therapeutic target for GBM. Enhancing ...
BET inhibition synergizes with RLR signaling to enhance tumor immunogenicity and T cell recognition [0.03%]
BET抑制与RLR信号传导协同作用以增强肿瘤免疫原性和T细胞识别
Lucas Baldran-Groves,Rok Žiberna,Marc-Antoine Gerault et al.
Lucas Baldran-Groves et al.
Intratumoral signaling via the cytosolic double-stranded RNA (dsRNA) receptors RIG-I and MDA-5 enhance antitumor immunity and can overcome resistance to cancer immunotherapy. Although BET proteins are established epigenetic drivers of immun...
In situ vaccination, low-dose targeted radionuclide therapy, and immune checkpoint inhibition eradicate poorly immunogenic metastatic tumors in murine cancer models [0.03%]
就地接种，低剂量靶向放射性核素治疗和免疫检查点抑制可根除小鼠癌症模型中不易引起免疫反应的转移性肿瘤
Trishna Debnath,Won Jong Jin,Ravi B Patel et al.
Trishna Debnath et al.
Focal radiotherapy can provide an in situ vaccine (ISV) effect that may prime adaptive antitumor immunity, which can be augmented by combination with intratumoral immune adjuvants and systemic immune checkpoint inhibition. However, propagat...