Cytokine pathways driving diverse tissue pathologies in rheumatoid arthritis [0.03%]
类风湿关节炎中驱动多种组织病理的细胞因子通路
Aurelie Najm,Lyn D Ferguson,Iain B McInnes
Aurelie Najm
Rheumatoid arthritis is a complex systemic disorder characterised primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra-articular disease e.g. of th...
ADAM9 Promotes Glycolysis in Th17 Cells and Autoimmunity Through Activation of IGF-1 Signaling [0.03%]
ADAM9通过激活IGF-1信号促进Th17细胞糖酵解及自身免疫反应
Kohei Karino,Masataka Umeda,Theodoros Vichos et al.
Kohei Karino et al.
Objective: Interleukin-17-producing CD4+ Th17 cells contribute to the pathogenesis of autoimmune diseases, including crescentic glomerulonephritis. Although ADAM9 has been reported to contribute to organ inflammation, the...
ROS-induced modifications of fibrin clots connect immune responses to atherothrombosis in systemic lupus erythematosus [0.03%]
ROS诱导的抗磷脂抗体对纤维蛋白凝块的作用及免疫反应与系统性红斑狼疮动脉粥样血栓形成的关系
Matteo Becatti,Giacomo Emmi,Alessandra Bettiol et al.
Matteo Becatti et al.
Objective: Cardiovascular events are major determinants of morbidity and mortality in systemic lupus erythematosus (SLE), particularly in patients with renal involvement. While oxidative stress has been implicated in driv...
Romain Aymon,Delphine S Courvoisier,Axel Finckh et al.
Romain Aymon et al.
Skin biopsies enhance prediction of clinical trajectory in diffuse cutaneous systemic sclerosis [0.03%]
皮肤活检可提高弥漫性皮肤系统性硬化症临床病程预测的准确性
Kimberly S Lakin,John Spivack,Jessica K Gordon et al.
Kimberly S Lakin et al.
Objectives: To evaluate the relationship of skin fibroblast CD34 and aSMA and immune cell infiltration with disease duration in diffuse cutaneous systemic sclerosis (dcSSc) and identify predictors of improvement. ...
Progressive calcinosis cutis universalis involving the intrapelvic muscles in systemic lupus erythematosus [0.03%]
系统性红斑狼疮合并进行性全身皮肤钙化的两名患者报告：包括盆肌内病变
Takeshi Zoshima,Yasunori Iwata
Takeshi Zoshima
A phase 2 trial of hydroxychloroquine in individuals at risk for rheumatoid arthritis [0.03%]
羟氯喹对患类风湿关节炎风险个体影响的二期临床试验
Kevin D Deane,Christopher C Striebich,Marie L Feser et al.
Kevin D Deane et al.
Background: Individuals with serum elevations of anti-cyclic citrullinated peptide (anti-CCP) antibodies are at increased risk for future rheumatoid arthritis (RA). No pharmacologic interventions have been approved for th...
Spermidine reproduces the anti-inflammatory effects of intermittent fasting and prevents urate and calcium pyrophosphate crystal-induced inflammation [0.03%]
spermidine复制间歇性禁食的抗炎作用并预防尿酸和焦磷酸钙晶体引起的炎症
Chinh Nghia Pham,Florence Castelli,Flora Finet et al.
Chinh Nghia Pham et al.
Background: Gout due to the formation of monosodium urate (MSU) crystals and calcium pyrophosphate (CPP) deposition disease are two major types of microcrystalline pathologies in adults. They are responsible for recurrent...
Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic syndrome presenting as aseptic pustular dermatosis: A rare clinical manifestation [0.03%]
遗传性大疱性表皮松解症伴腮腺肿大的临床表现及基因型分析：两例报道及其父亲的突变筛查
Peter Chen,Héloïse Briançon,Deborah Eshagh et al.
Peter Chen et al.