Genetic and Population Analyses Implicate Thyroid-Related Regulation of RNF144B in Chondrocalcinosis [0.03%]
基因和群体分析揭示甲状腺相关因子RNF144B的多态性通过影响软骨钙化导致关节炎发生的机制
Yahong Wu,Yanning Xu,Paul C Okoro et al.
Yahong Wu et al.
Objective: Chondrocalcinosis, characterized by calcium crystal deposition within articular cartilage, affects 5% to 15% of the general population and has recently been identified as an osteoarthritis risk factor. However,...
Abatacept Reduces CD319+ (SLAMF7) Cytotoxic T Cells and Cytokine Production in Systemic Sclerosis [0.03%]
阿巴西普减少系统性硬化症中的CD319+(SLAMF7)细胞毒性T淋巴细胞及其细胞因子生成
Mikel Gurrea-Rubio,Laura A Cooney,Kohei Maeda et al.
Mikel Gurrea-Rubio et al.
Objective: Systemic sclerosis (SSc) is characterized by immune dysregulation and fibrosis. We investigated whether abatacept modulates CD319/SLAMF7-expressing cytotoxic T cells implicated in diffuse cutaneous SSc. ...
FSCN1 Promotes Rheumatoid Arthritis Progression via Inhibiting TRIM38-Mediated Ubiquitination of IGF2BP1 in Fibroblast-Like Synoviocytes [0.03%]
FSCN1通过抑制成纤维细胞样滑膜细胞中TRIM38介导的IGF2BP1泛素化促进类风湿关节炎进展
Liangyu Chen,Junfeng Wu,Tao Zhou et al.
Liangyu Chen et al.
Objective: Fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA) synovium acquire a unique aggressive phenotype and produce cytokines that perpetuate inflammation and proteases that contribute to cartilage destr...
Risk of Cancer According to Duration of Targeted Therapy Exposure in Spondyloarthritis: A Nationwide Cohort Study From the French Health Insurance Database [0.03%]
基于法国健康保险数据库的全国队列研究：银屑病关节炎靶向治疗暴露持续时间与癌症风险的关系
Karine Tankovic,Pascal Claudepierre,Tat Thang Vo et al.
Karine Tankovic et al.
Objective: To assess the association between duration of targeted therapy exposure and cancer risk in patients with spondyloarthritis (SpA), including those with psoriatic arthritis, axial SpA, and other subtypes. ...
Type I interferon drives dysfunction of a distinct CD8+ HLA-DRB1+ T cell subset in systemic lupus erythematosus [0.03%]
I型干扰素驱动自身免疫性狼疮中一类特异CD8+ HLA-DRB1+ T细胞功能障碍
Huizhong Long,Elio Carmona,Mikhail G Dozmorov et al.
Huizhong Long et al.
Objective: Systemic lupus erythematosus (SLE) is characterized by type I interferon (IFN) signaling and adaptive immune dysregulation. We previously identified hypomethylation of HLA-DRB1 and STAT1 in SLE CD8+ T cells, en...
AI Holds the Potential for More Uniform and Scalable Joint Radiographic Grading [0.03%]
人工智能具有更均匀和可扩展的关节放射图形分级的潜力
John A Carrino,Olga Kubassova
John A Carrino
Anifrolumab versus Belimumab for Cardiovascular Disease Risk in Systemic Lupus Erythematosus [0.03%]
抗环瓜氨酸肽抗体阴性的类风湿关节炎患者接受阿尼夫单抗与倍利珠单抗对心血管疾病风险的影响
Arjun Mahajan,Maureen Whittelsey,Ruth Ann Vleugels et al.
Arjun Mahajan et al.
Objective: Current guidelines recommend anifrolumab and belimumab as comparably viable immunosuppressive therapies for active systemic lupus erythematosus (SLE), yet comparative evidence remains limited. Patients with SLE...
Joel A Block
Joel A Block
Despite revolutionary advances in therapeutics for many of the inflammatory rheumatic diseases, osteoarthritis (OA) has not been one of the diseases for which therapy has advanced dramatically, and OA pain frequently remains incompletely co...
Age-associated B cells contribute to inflammation via antibody-independent mechanisms in Takayasu's arteritis [0.03%]
年龄相关B细胞通过抗体独立机制在Takayasu动脉炎中促炎症反应
Chenglong Fang,Xiaoxi Yang,Xiaochuan Sun et al.
Chenglong Fang et al.
Objective: Although Takayasu's arteritis (TAK) is not a prototypical autoantibody-mediated disease, accumulating evidence suggests that B cells are involved. This study aimed to investigate the pathway of B-cell activatio...
Outcomes in progressive pulmonary fibrosis in systemic autoimmune rheumatic diseases: real-world data from the ILD-PRO Registry [0.03%]
系统性自身免疫性疾病中进行性肺纤维化患者的预后：来自ILD-PRO注册研究的真实世界数据
Sonali J Bracken,Jeremy M Weber,Megan L Neely et al.
Sonali J Bracken et al.
Objective: We evaluated baseline characteristics, treatment patterns, and outcomes in patients with systemic autoimmune rheumatic disease-associated progressive pulmonary fibrosis (SARD-PPF) and evaluated whether outcomes...