The nuclear receptor TR4 orchestrates cytoskeletal organization in a Gα12/ROCK-dependent manner to promote myofibroblast differentiation and tissue fibrosis in systemic sclerosis [0.03%]
系统性硬化病中核受体TR4通过Gα12/ROCK依赖方式调控细胞骨架组织以促进肌成纤维细胞分化和组织纤维化
Yun Zhang,Lichong Shen,Junhui Zheng et al.
Yun Zhang et al.
Objective: Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, t...
"More Guidelines Than Rules": Reconsidering Key Gaps in the 2025 American College of Rheumatology Treatment Recommendations for Systemic Lupus Erythematosus [0.03%]
“更多的指导原则而非规定”：重新审视2025年美国风湿病学会系统性红斑狼疮治疗建议中的关键缺口
Saira Sheikh,Karen H Costenbader,Joan T Merrill et al.
Saira Sheikh et al.
Authors' Reply [0.03%]
作者回复
Alí Duarte-García,Anca Askanase,Bonnie L Bermas et al.
Alí Duarte-García et al.
Low-Grade Proteinuria in Lupus Nephritis: Why "Mild" Is Often Misleading [0.03%]
狼疮性肾炎低水平蛋白尿：为什么“轻度”往往会具有欺骗性
Ana Malvar,Valeria Alberton,Brad H Rovin
Ana Malvar
Jinjian Fu,Jun Wang,Qing Zhou et al.
Jinjian Fu et al.
The American College of Rheumatology Updated Recommended Methods for Development of Disease Classification and Response Criteria [0.03%]
美国风湿病学会分类和疗效标准制定方法的更新建议
Sindhu R Johnson,Tuhina Neogi,Amy S Turner et al.
Sindhu R Johnson et al.
Disease classification criteria and response criteria are important tools in the conduct of observational studies and clinical trials for rheumatic diseases. This paper updates methodologic guidance for classification and response criteria ...
A Pragmatic Trial of a Shared Decision-Making Intervention to Improve Medication Adherence and Outcomes in Systemic Lupus Erythematosus: The HCQ-SAFE Study [0.03%]
系统性红斑狼疮改善羟氯喹依从性的共同决策干预 pragmatic试验：HCQ SAFE研究
Caroline Packee,Jay J Patel,Jessica Kent et al.
Caroline Packee et al.
Objectives: Hydroxychloroquine (HCQ) nonadherence in systemic lupus erythematosus (SLE) stemming from decision complexities can be improved with shared decision-making (SDM) tools clarifying benefits and harms. This study...
Glomerular endothelial rarefaction associated with hypoxic neutrophils marks renal pathology activity in lupus nephritis [0.03%]
狼疮性肾炎肾病理活动的标志是与低氧中性粒细胞相关的系膜内皮稀释现象
Anto Sam Crosslee Louis Sam Titus,Aalekhya Biswas,Vishal Srinivasan et al.
Anto Sam Crosslee Louis Sam Titus et al.
Objectives: This study aims to investigate the spatial transcriptomics of hypoxia and immune-mediated damage within renal tissue in patients with lupus nephritis (LN) in comparison to healthy controls from kidney transpla...
Mansi K Aparnathi,Nigil Haroon
Mansi K Aparnathi
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review we synthesize current knowledge on diverse T cell subse...