Linezolid prevents fibroblast activation and ameliorates tissue fibrosis by inhibition of mitochondrial translation [0.03%]
利奈唑胺通过抑制线粒体蛋白质合成阻止纤维母细胞活化和改善组织纤维化
Xuezhi Hong,Yanhua Xiao,Haodong Qi et al.
Xuezhi Hong et al.
Biopsy-Proven Hydroxychloroquine-Induced Cardiomyopathy in an Adolescent With Systemic Lupus Erythematosus [0.03%]
一例系统性红斑狼疮青少年患者羟氯喹致心肌病1例（病理证实）
Greta Mastrangelo,Anita Nagy,Aamir Jeewa et al.
Greta Mastrangelo et al.
Lifelong evolution of autoreactive plasma cell numbers, affinity and anatomical location in arthritic K/BxN mice [0.03%]
胶原诱导关节炎K/BxN小鼠自身反应性浆细胞数量、亲和力及解剖位置的终生演变规律
Thibault Vanhoucke,Carlos Castrillon,Odile Richard-Le Goff et al.
Thibault Vanhoucke et al.
Objective: The spontaneous K/BxN mouse model of rheumatoid arthritis has been used extensively to study chronic inflammation, contribution of immune cells, and the primordial role of autoreactive antibodies in disease ini...
Identification of histone deacetylase inhibitor targeting type I interferon and B-cell abnormalities in systemic lupus erythematosus [0.03%]
系统性红斑狼疮中组蛋白去乙酰化酶抑制剂的鉴定：靶向I型干扰素和B细胞异常
Takehiro Hirayama,Hachiro Konaka,Yasuhiro Kato et al.
Takehiro Hirayama et al.
Objective: Systemic lupus erythematosus (SLE) is characterized by increased type I interferon (IFN-I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN-I and autoantibody production...
Immunological Profiling suggests an Association between Treg dysfunction and Pain in Knee Osteoarthritis [0.03%]
免疫学特征分析提示膝骨关节炎疼痛与调节性T细胞功能障碍有关
Marie Binvignat,Johanna Dubois,Maria Marco Salvador et al.
Marie Binvignat et al.
Background: Pain is the hallmark symptom of osteoarthritis (OA) and its biological drivers remain poorly understood. While the role of innate immunity in OA has been extensively studied, the involvement of adaptive immuni...
The relation of colchicine to total joint arthroplasty among people with gout in a population-based cohort study [0.03%]
基于人群的队列研究中痛风患者小分子抗炎药与全关节置换关系的研究
Zhiqiang Wang,Sarah Tilley,Christine Peloquin et al.
Zhiqiang Wang et al.
Objectives: To evaluate the relation of colchicine use to the risk of total joint arthroplasty (TJA) in individuals with gout, the most common form of arthritis for which colchicine is prescribed. ...
Alkaptonuria: A Conundrum [0.03%]
醋酸尿症的诊治难题
Sarada Khandual,Sarit Pattanaik,Saumya Tripathy et al.
Sarada Khandual et al.
A 74-year-old hypertensive male presented with longstanding generalised aches, flexor contractures of the palms, and progressive tingling and numbness in his extremities. Examination reported classic signs of ochronosis, including blackish ...
Emilie Dumas,Dirk Elewaut
Emilie Dumas
Gut microbiota-derived tryptophan indole metabolites ameliorate collagen-induced arthritis in mice via aryl hydrocarbon receptor activation in T cells and intestinal epithelial cells [0.03%]
肠道微生物色氨酸吲哚代谢物通过T细胞和肠上皮细胞中的芳香烃受体活化缓解小鼠胶原诱导的关节炎
Liang Wu,Qiuping Zhang,Zhigang Tang et al.
Liang Wu et al.
Objective: To investigate the specific role of tryptophan metabolism, especially that of microbiome-derived metabolites, in the development of rheumatoid arthritis (RA). ...