Gene Therapy Briefs [0.03%]
基因治疗简报
Alex Philippidis
Alex Philippidis
The Influence of Murine Genetic Background in Adeno-Associated Virus Transduction of the Mouse Brain [0.03%]
遗传背景对腺相关病毒转导小鼠大脑的影响
Ting He,Michelle S Itano,Lauriel F Earley et al.
Ting He et al.
Adeno-associated virus (AAV) vectors have become an important tool for delivering therapeutic genes for a wide range of neurological diseases. AAV serotypes possess differential cellular tropism in the central nervous system. Although sever...
Inhibition of miR-203 Ameliorates Osteoarthritis Cartilage Degradation in the Postmenopausal Rat Model: Involvement of Estrogen Receptor α [0.03%]
miR-203抑制缓解绝经后膝骨关节炎软骨降解：涉及雌激素受体α参与
Lijun Tian,Zhiyong Su,Xiaobin Ma et al.
Lijun Tian et al.
miR-203 is known to target estrogen receptor α (ERα) in various cancer cell lines, such as MCF-7. However, whether miR-203 regulates ERα and contributes to the onset and progression of osteoarthritis (OA) is poorly understood. A combined...
MiR-625-5p Inhibits Cardiac Hypertrophy Through Targeting STAT3 and CaMKII [0.03%]
miR-625-5p通过靶向STAT3和CaMKII抑制心室肥大
Kefeng Cai,Huiqin Chen
Kefeng Cai
Cardiac hypertrophy is an adaptive cardiac response to heart stress. Sustained cardiac hypertrophy indicates higher risk of heart failure. Ca2+/calmodulin-dependent protein kinase II (CaMKII) has been proved to be a key regulator of cardiac...
Gene Therapy Briefs [0.03%]
基因治疗简报
Alex Philippidis
Alex Philippidis
Circular RNA circVAPA Promotes Cell Proliferation in Hepatocellular Carcinoma [0.03%]
Circular RNA circVAPA通过调控miR-574-3p/PUM1轴促进肝癌细胞增殖的作用及机制研究
Caifeng Liu,Xingyang Zhong,Jun Li et al.
Caifeng Liu et al.
Hepatocellular carcinoma (HCC) is the most common malignancy in liver and is one of the leading causes of cancer-induced deaths all over the world. Circular RNAs (circRNAs) have been proven to be related to cancer initiation and progression...
MicroRNA-4513 Promotes Gastric Cancer Cell Proliferation and Epithelial-Mesenchymal Transition Through Targeting KAT6B [0.03%]
microRNA-4513通过靶向KAT6B促进胃癌细胞增殖和上皮间质转化
Huimin Ding,Yuhua Shi,Xiaobing Liu et al.
Huimin Ding et al.
The purpose of this study was to investigate the expression level of microRNA-4513 (miR-4513) in gastric cancer (GC), and to elucidate the mechanisms underlying its regulation of GC progression. Quantitative real-time PCR (qRT-PCR) was perf...
James M Wilson
James M Wilson
Editor's note: Sir Patrick Vallance is Government Chief Scientific Adviser in the United Kingdom. Here he discusses his path from academia to industry to government, and he reflects on the crucial early conversations that were instrumental ...