One more stem cell niche: how the sensitivity of chronic myeloid leukemia cells to imatinib mesylate is modulated within a "hypoxic" environment [0.03%]
慢性粒细胞白血病细胞在“低氧”环境下的“干细胞生态位”是如何调控伊马替尼的敏感性
Elisabetta Rovida,Ilaria Marzi,Maria Grazia Cipolleschi et al.
Elisabetta Rovida et al.
This is a review (by no means comprehensive) of how the stem cell niche evolved from an abstract concept to a complex system, implemented with a number of experimental data at the cellular and molecular levels, including metabolic cues, on ...
Dörthe M Katschinski
Dörthe M Katschinski
The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth [0.03%]
2氧戊二酸类似物3氧戊二酸通过降低癌细胞中常压缺氧诱导因子-1α诱导细胞死亡并减少异种移植肿瘤的生长
Peppi Koivunen,Stuart M Fell,Wenyun Lu et al.
Peppi Koivunen et al.
The cellular response to hypoxia is primarily regulated by the hypoxia-inducible factors (HIFs). HIF-1α is also a major mediator of tumor physiology, and its abundance is correlated with therapeutic resistance in a broad range of cancers. ...
Prolyl-hydroxylase 3: Evolving Roles for an Ancient Signaling Protein [0.03%]
脯氨酰羟化酶3：一种古老的信号蛋白的进化中的作用
Trenton L Place,Frederick E Domann
Trenton L Place
The ability of cells to sense oxygen is a highly evolved process that facilitates adaptations to the local oxygen environment and is critical to energy homeostasis. In vertebrates, this process is largely controlled by three intracellular p...
Hypoxia Attenuates Purinergic P2X Receptor-Induced Inflammatory Gene Expression in Brainstem Microglia [0.03%]
缺氧减轻脑干小胶质细胞中嘌呤能P2X受体诱导的炎症基因表达
Stephanie M C Smith,Gordon S Mitchell,Scott A Friedle et al.
Stephanie M C Smith et al.
Hypoxia and increased extracellular nucleotides are frequently coincident in the brainstem. Extracellular nucleotides are potent modulators of microglial inflammatory gene expression via P2X purinergic receptor activation. Although hypoxia ...