Nathalie E Zeitouni,Joachim Fandrey,Hassan Y Naim et al.
Nathalie E Zeitouni et al.
Purpose: Measuring oxygen levels in three different systems of Caco-2 cell culture. Methods: Caco-2 cells were cultured in three differ...
Aurelia Lelli,Karen A Nolan,Sara Santambrogio et al.
Aurelia Lelli et al.
Long thought to be "junk DNA", in recent years it has become clear that a substantial fraction of intergenic genomic DNA is actually transcribed, forming long noncoding RNA (lncRNA). Like mRNA, lncRNA can also be spliced, capped, and polyad...
Roland H Wenger,Vartan Kurtcuoglu,Carsten C Scholz et al.
Roland H Wenger et al.
"What is the O2 concentration in a normoxic cell culture incubator?" This and other frequently asked questions in hypoxia research will be answered in this review. Our intention is to give a simple introduction to the physics of gases that ...
Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival [0.03%]
慢性低血氧条件下侧脑室神经干细胞的抗衰老性及其生殖中心结构紊乱及神经元和少突胶质细胞存活率下降的现象研究
Xavier d&#x;Anglemont de Tassigny,M Salomé Sirerol-Piquer,Ulises Gómez-Pinedo et al.
Xavier d&#x;Anglemont de Tassigny et al.
Chronic hypoxemia, as evidenced in de-acclimatized high-altitude residents or in patients with chronic obstructive respiratory disorders, is a common medical condition that can produce serious neurological alterations. However, the pathogen...
Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges [0.03%]
脯氨酰羟化酶结构域含酶在手术中的治疗抑制：潜在应用和挑战
Jonathan Michael Harnoss,Moritz Johannes Strowitzki,Praveen Radhakrishnan et al.
Jonathan Michael Harnoss et al.
Oxygen is essential for metazoans to generate energy. Upon oxygen deprivation adaptive and protective pathways are induced, mediated by hypoxia-inducible factors (HIFs) and prolyl hydroxylase domain-containing enzymes (PHDs). Both play a pi...
Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectives [0.03%]
低氧诱导因子羟化酶介导的低氧信号转导的历史回顾及未来展望
Tammie Bishop,Peter J Ratcliffe
Tammie Bishop
By the early 1900s, the close matching of oxygen supply with demand was recognized to be a fundamental requirement for physiological function, and multiple adaptive responses to environment hypoxia had been described. Nevertheless, the wide...
Simon Tazzyman,Craig Murdoch,James Yeomans et al.
Simon Tazzyman et al.
Hypoxia plays a critical role in the pathobiology of various inflamed, diseased tissues, including malignant tumors, atherosclerotic plaques, myocardial infarcts, the synovia of rheumatoid arthritic joints, healing wounds, and sites of bact...
Regulation of obesity and insulin resistance by hypoxia-inducible factors [0.03%]
缺氧诱导因子对肥胖和胰岛素抵抗的调节作用
Jae-Jun Ban,Robin J Ruthenborg,Kevin W Cho et al.
Jae-Jun Ban et al.
In obesity, dysregulated metabolism and aberrant expansion of adipose tissue lead to the development of tissue hypoxia that plays an important role in contributing to obesity-associated metabolic disorders. Recent studies utilizing adipocyt...
Effects of copper sulfate-oxidized or myeloperoxidase-modified LDL on lipid loading and programmed cell death in macrophages under hypoxia [0.03%]
硫酸铜氧化或髓过氧化物酶修饰的LDL对巨噬细胞低氧条件下脂质积累和程序性细胞死亡的影响
Benoit Vlaminck,Damien Calay,Marie Genin et al.
Benoit Vlaminck et al.
Atheromatous plaques contain heavily lipid-loaded macrophages that die, hence generating the necrotic core of these plaques. Since plaque instability and rupture is often correlated with a large necrotic core, it is important to understand ...
Arginine-vasopressin marker copeptin is a sensitive plasma surrogate of hypoxic exposure [0.03%]
精氨酸加压素标志物copeptin是缺氧暴露的敏感血浆替代物
Louise Ostergaard,Alain Rudiger,Sven Wellmann et al.
Louise Ostergaard et al.
Background: A reduced oxygen supply puts patients at risk of tissue hypoxia, organ damage, and even death. In response, several changes are activated that allow for at least partial adaptation, thereby increasing the chan...