Sevoflurane mitigates shedding of hyaluronan from the coronary endothelium, also during ischemia/reperfusion: an ex vivo animal study [0.03%]
异氟醚减轻冠状动脉内皮缺血再灌注时透明质酸的脱落：一项离体动物研究
Congcong Chen,Daniel Chappell,Thorsten Annecke et al.
Congcong Chen et al.
Glycosaminoglycan hyaluronan (HA), a major constituent of the endothelial glycocalyx, helps to maintain vascular integrity. Preconditioning the heart with volatile anesthetic agents protects against ischemia/reperfusion injury. We investiga...
Hyperplasia and hypertrophy of pulmonary neuroepithelial bodies, presumed airway hypoxia sensors, in hypoxia-inducible factor prolyl hydroxylase-deficient mice [0.03%]
缺氧诱导因子脯氨酰羟化酶敲除小鼠肺神经上皮细胞团增生和肥大，其为假定的气道低氧感受器
Jie Pan,Tammie Bishop,Peter J Ratcliffe et al.
Jie Pan et al.
Pulmonary neuroepithelial bodies (NEBs), presumed polymodal airway sensors, consist of innervated clusters of amine (serotonin) and peptide-producing cells. While NEB responses to acute hypoxia are mediated by a membrane-bound O2 sensor com...
Ana M Meneses,Ben Wielockx
Ana M Meneses
Oxygen represents one of the major molecules required for the development and maintenance of life. An adequate response to hypoxia is therefore required for the functioning of the majority of living organisms and relies on the activation of...
Ascorbate availability affects tumor implantation-take rate and increases tumor rejection in Gulo-/- mice [0.03%]
维生素C的获得性影响肿瘤接种成功率以及通过增加Gulo-/-小鼠体内维生素C的含量来提高其排斥肿瘤的可能性
Elizabeth J Campbell,Margreet Cm Vissers,Gabi U Dachs
Elizabeth J Campbell
In solid tumors, HIF1 upregulates the expression of hundreds of genes involved in cell survival, tumor growth, and adaptation to the hypoxic microenvironment. HIF1 stabilization and activity are suppressed by prolyl and asparagine hydroxyla...
Erythropoietin and the use of a transgenic model of erythropoietin-deficient mice [0.03%]
促红细胞生成素及制作缺促红细胞生成素小鼠的转基因模型的应用
Aurélien Pichon,Florine Jeton,Raja El Hasnaoui-Saadani et al.
Aurélien Pichon et al.
Despite its well-known role in red blood cell production, it is now accepted that erythropoietin (Epo) has other physiological functions. Epo and its receptors are expressed in many tissues, such as the brain and heart. The presence of Epo/...
Fifteen days of 3,200 m simulated hypoxia marginally regulates markers for protein synthesis and degradation in human skeletal muscle [0.03%]
15天的模拟低氧暴露对人类骨骼肌蛋白合成和降解标志物的影响较小
Gommaar D&#x;Hulst,Alessandra Ferri,Damien Naslain et al.
Gommaar D&#x;Hulst et al.
Chronic hypoxia leads to muscle atrophy. The molecular mechanisms responsible for this phenomenon are not well defined in vivo. We sought to determine how chronic hypoxia regulates molecular markers of protein synthesis and degradation in h...
New perspectives on the molecular basis of the interaction between oxygen homeostasis and iron metabolism [0.03%]
氧稳态与铁代谢相互作用的分子机制新见解
Stefania Recalcati,Elena Gammella,Gaetano Cairo
Stefania Recalcati
Oxygen and iron are two elements closely related from a (bio)chemical point of view. Moreover, they share the characteristic of being indispensable for life, while also being potentially toxic. Therefore, their level is strictly monitored, ...
The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy [0.03%]
缺氧在癌症发展、血管生成、转移和治疗抗性中的作用
Barbara Muz,Pilar de la Puente,Feda Azab et al.
Barbara Muz et al.
Hypoxia is a non-physiological level of oxygen tension, a phenomenon common in a majority of malignant tumors. Tumor-hypoxia leads to advanced but dysfunctional vascularization and acquisition of epithelial-to-mesenchymal transition phenoty...
Hypoxic regulation of osteoclast differentiation and bone resorption activity [0.03%]
缺氧对破骨细胞分化和骨吸收功能的调节作用
Helen J Knowles
Helen J Knowles
Bone integrity is maintained throughout life via the homeostatic actions of bone cells, namely, osteoclasts, which resorb bone, and osteoblasts, which produce bone. Disruption of this balance in favor of osteoclast activation results in pat...
Hypoxia: from basic mechanisms to therapeutics - a meeting report on the Keystone and HypoxiaNet Symposium [0.03%]
缺氧：从中枢机制到药物治疗——关于Keystone和HypoxiaNet专题讨论会的报告
Karen A Nolan,Carsten C Scholz
Karen A Nolan
In May 2015, the hypoxia research community came together at the largest meeting in this field to date, to present and discuss their most recent and mainly unpublished findings. This meeting report aims to summarize the data presented at th...