Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics [0.03%]
缺氧诱导因子和氧气调控通路中的羟化酶研究进展：从生理学到治疗学
Peter Ratcliffe,Peppi Koivunen,Johanna Myllyharju et al.
Peter Ratcliffe et al.
The "Hypoxia Nantes 2016" organized its second conference dedicated to the field of hypoxia research. This conference focused on "the role of hypoxia under physiological conditions as well as in cancer" and took place in Nantes, France, in ...
Induction of erythropoiesis by hypoxia-inducible factor prolyl hydroxylase inhibitors without promotion of tumor initiation, progression, or metastasis in a VEGF-sensitive model of spontaneous breast cancer [0.03%]
缺氧诱导因子脯氨酸羟化酶抑制剂诱发红细胞生成而不促进血管内皮生长因子敏感自发性乳腺癌的肿瘤发生、发展或转移诱导
Todd W Seeley,Mark D Sternlicht,Stephen J Klaus et al.
Todd W Seeley et al.
The effects of pharmacological hypoxia-inducible factor (HIF) stabilization were investigated in the MMTV-Neundl-YD5 (NeuYD) mouse model of breast cancer. This study first confirmed the sensitivity of this model to increased vascular endoth...
Combination effects of sorafenib with PI3K inhibitors under hypoxia in colorectal cancer [0.03%]
缺氧条件下索拉非尼联合PI3K抑制剂治疗结直肠癌的协同作用研究
Dimple R Bhatia,Padma Thiagarajan
Dimple R Bhatia
Aim: This study reports the influence of hypoxia on response of colorectal cancer cells to anticancer effects of sorafenib in combination with PI3K inhibitors GDC-0941 and BEZ-235. ...
The Three "Musketairs" - Lasker Prize 2016 goes to the protagonists of hypoxia research [0.03%]
三名“ Musketeers”获得2016年Lasker奖生理学与医学奖
Roland H Wenger,Dörthe M Katschinski
Roland H Wenger
Helen E Ritchie,Carolina Ragnerstam,Elin Gustafsson et al.
Helen E Ritchie et al.
The aim of this study was to gain insight into whether the first trimester embryo could control its own heart rate (HR) in response to hypoxia. The gestational day 13 rat embryo is a good model for the human embryo at 5-6 weeks gestation, a...
Phosphorylation of the pyruvate dehydrogenase complex precedes HIF-1-mediated effects and pyruvate dehydrogenase kinase 1 upregulation during the first hours of hypoxic treatment in hepatocellular carcinoma cells [0.03%]
缺氧处理肝癌细胞初期PDH复合体磷酸化先于HIF-1介导的效应和丙酮酸脱氢酶激酶1上调
Andreas David Zimmer,Geoffroy Walbrecq,Ines Kozar et al.
Andreas David Zimmer et al.
The pyruvate dehydrogenase complex (PDC) is an important gatekeeper enzyme connecting glycolysis to the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). Thereby, it has a strong impact on the glycolytic flux as well as...
Erythropoietin and a nonerythropoietic peptide analog promote aortic endothelial cell repair under hypoxic conditions: role of nitric oxide [0.03%]
缺氧条件下促红细胞生成素和非促红细胞生成素肽类似物通过提高一氧化氮水平促进主动脉内皮细胞修复的作用：一氧化氮的作用研究
Lamia Heikal,Pietro Ghezzi,Manuela Mengozzi et al.
Lamia Heikal et al.
The cytoprotective effects of erythropoietin (EPO) and an EPO-related nonerythropoietic analog, pyroglutamate helix B surface peptide (pHBSP), were investigated in an in vitro model of bovine aortic endothelial cell injury under normoxic (2...
Preconditioning with ethyl 3,4-dihydroxybenzoate augments aerobic respiration in rat skeletal muscle [0.03%]
乙基3,4-二羟基苯甲酸预处理可增强大鼠骨骼肌的有氧呼吸作用
Charu Nimker,Deependra Pratap Singh,Deepika Saraswat et al.
Charu Nimker et al.
Muscle respiratory capacity decides the amount of exertion one's skeletal muscle can undergo, and endurance exercise is believed to increase it. There are also certain preconditioning methods by which muscle respiratory and exercise perform...
Chronic intermittent hypoxia and obstructive sleep apnea: an experimental and clinical approach [0.03%]
慢性间歇性缺氧和阻塞性睡眠呼吸暂停：一种实验与临床方法研究
Emilia Sforza,Fréderic Roche
Emilia Sforza
Obstructive sleep apnea (OSA) is a prevalent sleep disorder considered as an independent risk factor for cardiovascular consequences, such as systemic arterial hypertension, ischemic heart disease, cardiac arrhythmias, metabolic disorders, ...
David Hoogewijs,Melanie Vogler,Eveline Zwenger et al.
David Hoogewijs et al.
The purpose of this study was to investigate whether aquaporin-3 (AQP3) expression is altered in hypoxia and whether hypoxia-inducible transcription factor (HIF)-1 regulates the hypoxic expression. AQP3 mRNA expression was studied in L929 f...