Astrocyte HIF-2α supports learning in a passive avoidance paradigm under hypoxic stress [0.03%]
缺氧应激下星形胶质细胞HIF-2α在被动回避范式中支持学习记忆能力
Cindy V Leiton,Elyssa Chen,Alissa Cutrone et al.
Cindy V Leiton et al.
Background: The brain is extensively vascularized, useŝ20% of the body's oxygen, and is highly sensitive to changes in oxygen. While synaptic plasticity and memory are impaired in healthy individuals by exposure to mild ...
A novel approach to target hypoxic cancer cells via combining β-oxidation inhibitor etomoxir with radiation [0.03%]
一种通过结合β氧化抑制剂乙氧imet及其与放射治疗联用靶向缺氧肿瘤细胞的新方法
Arpit Dheeraj,Chapla Agarwal,Isabel R Schlaepfer et al.
Arpit Dheeraj et al.
Background: Hypoxia in tumors is associated with resistance towards various therapies including radiotherapy. In this study, we assessed if hypoxia in cancer spheres could be effectively reduced by adding etomoxir (a β-o...
Effects of human relaxin-2 (serelaxin) on hypoxic pulmonary vasoconstriction during acute hypoxia in a sheep model [0.03%]
人relaxin-2（serelaxin）对急性缺氧条件下绵羊模型低氧性肺血管收缩的影响
René Schiffner,Marius Nistor,Sabine Juliane Bischoff et al.
René Schiffner et al.
Purpose: Hypoxia induces pulmonary vasoconstriction with a subsequent increase of pulmonary artery pressure (PAP), which can result in pulmonary hypertension. Serelaxin has shown an increase of pulmonary hemodynamic param...
A multichannel computer-driven system to raise aquatic embryos under selectable hypoxic conditions [0.03%]
一种多通道计算机驱动的系统在可选择缺氧条件下培养水生胚胎
Sanjeeva Metikala,Herbert Neuhaus,Thomas Hollemann
Sanjeeva Metikala
The formation of a functional cardiovascular system is an essential step in the early vertebrate embryo. Nevertheless, the effect of hypoxia on the developmental program of organisms was studied rarely. In particular, this holds true for ve...
Respiratory muscle dysfunction in animal models of hypoxic disease: antioxidant therapy goes from strength to strength [0.03%]
缺氧疾病动物模型中的呼吸肌功能障碍：抗氧化疗法不断取得进展
Ken D O&#x;Halloran,Philip Lewis
Ken D O&#x;Halloran
The striated muscles of breathing play a critical role in respiratory homeostasis governing blood oxygenation and pH regulation. Upper airway dilator and thoracic pump muscles retain a remarkable capacity for plasticity throughout life, bot...
SNPs, linkage disequilibrium, and chronic mountain sickness in Tibetan Chinese [0.03%]
藏人基因遗传与慢性高原病之间的关系研究
Norman E Buroker,Xue-Han Ning,Zhao-Nian Zhou et al.
Norman E Buroker et al.
Chronic mountain sickness (CMS) is estimated at 1.2% in Tibetans living at the Qinghai-Tibetan Plateau. Eighteen single-nucleotide polymorphisms (SNPs) from nine nuclear genes that have an association with CMS in Tibetans have been analyzed...
Targeted metabolomics in colorectal cancer: a strategic approach using standardized laboratory tests of the blood and urine [0.03%]
结直肠癌代谢组学的靶向策略研究：采用血液和尿液标准化实验室检测方法
Katarzyna J Jerzak,Marissa Laureano,Radwa Elsharawi et al.
Katarzyna J Jerzak et al.
Background: Glycolytic markers have been detected in colorectal cancer (CRC) using advanced analytical methods. Methods: Using commerci...
KEMTUB012-NI2, a novel potent tubulysin analog that selectively targets hypoxic cancer cells and is potentiated by cytochrome p450 reductase downregulation [0.03%]
一种新型强力管蛋白类化合物KEMTUB012-NI2，可选择性靶向缺氧癌细胞，并可通过细胞色素P450还原酶下调而被激活
Paolo Lazzari,Marco Spiga,Monica Sani et al.
Paolo Lazzari et al.
Purpose: There is an urgent need to develop effective therapies and treatment strategies to treat hypoxic tumors, which have a very poor prognosis and do not respond well to existing therapies. ...
Neuroprotection via RNA-binding protein RBM3 expression is regulated by hypothermia but not by hypoxia in human SK-N-SH neurons [0.03%]
RNA结合蛋白RBM3表达介导的神经保护作用由低温而非低氧在人SK-N-SH神经元中的调节
Lisa-Maria Rosenthal,Giang Tong,Christoph Walker et al.
Lisa-Maria Rosenthal et al.
Objective: Therapeutic hypothermia is an established treatment for perinatal asphyxia. Yet, many term infants continue to die or suffer from neurodevelopmental disability. Several experimental studies have demonstrated a ...
A review of the development of tumor vasculature and its effects on the tumor microenvironment [0.03%]
肿瘤血管生成及其对肿瘤微环境影响的研究进展综述
Jake C Forster,Wendy M Harriss-Phillips,Michael Jj Douglass et al.
Jake C Forster et al.
Background: The imbalance of angiogenic regulators in tumors drives tumor angiogenesis and causes the vasculature to develop much differently in tumors than in normal tissue. There are several cancer therapy techniques cu...