Single cell deciphering of pruritic keloids: the interaction between fibroblasts and Schwann cells through the Midkine signaling [0.03%]
单细胞测序技术解锁瘙痒性瘢痕疙瘩的发病机制：Midkine介导的成纤维细胞与施万细胞互作是关键
En Yang,Ruoqing Xu,Liying Tu et al.
En Yang et al.
Background: Keloids are a common skin fibroproliferative disease that can result in severe aesthetic and functional concerns. Pruritus and pain are the most prevalent clinical manifestations of keloids. Schwann cells (SCs...
Peroxisome proliferator-activated receptors-mediated diabetic wound healing regulates endothelial cells' mitochondrial function via sonic hedgehog signaling [0.03%]
过氧化物酶体增殖激活受体介导的糖尿病伤口愈合通过音猬因子信号调节内皮细胞线粒体功能
Shunli Rui,Fugang Xiao,Qin Li et al.
Shunli Rui et al.
Background: Diabetic foot ulcer (DFU) is a common and debilitating complication of diabetes, often leading to delayed wound healing. The peroxisome proliferator-activated receptors (PPARs) play a crucial role in regulatin...
Mechanical stretching enhances the cellular and paracrine effects of bone marrow mesenchymal stem cells on diabetic wound healing [0.03%]
机械拉伸促进骨髓间充质干细胞对糖尿病创面修复的细胞及旁分泌作用
Wei Dai,Haowei Zhou,Jincheng Du et al.
Wei Dai et al.
Background: Diabetic wounds present persistent clinical challenges characterized by disrupted extracellular matrix (ECM) homeostasis, which critically impedes tissue regeneration. While bone marrow-derived mesenchymal ste...
Fibroblast exosomes promote wound healing and improve the quality of healed skin via miR-29a-3p-mediated KEAP1/Nrf2 pathway activation [0.03%]
成纤维细胞外泌体通过miR-29a-3p介导的KEAP1/Nrf2通路激活促进伤口愈合并改善修复皮肤质量
Lingfeng Yan,Dejiang Fan,Jiacai Yang et al.
Lingfeng Yan et al.
Background: Wound healing is a sophisticated biological process characterized by the orchestrated interplay of diverse cellular components, growth factors, and signaling cascades. Recent research has highlighted the pivot...
Macrophage-derived exosome piR-50971 exacerbates sepsis-induced myocardial injury by inhibiting autophagy through the upregulation of N6-Methyladenosine modification of mTOR [0.03%]
巨噬细胞来源的外泌体piR-50971通过上调mTOR的N6-甲基腺苷修饰抑制自噬从而加重脓毒症诱导的心肌损伤
Jiaqiang Wang,Jie Zhang,Shan Zhong et al.
Jiaqiang Wang et al.
Background: Sepsis-induced myocardial injury (SIMI) is recognized as a severe complication of sepsis which characterized by a high mortality rate. Notably, the pathophysiology of SIMI involves complex mechanisms, includin...
Engineered sEVs encapsulated in GelMA facilitated diabetic wound healing by promoting angiogenesis via targeting thrombospondin-1 [0.03%]
工程化sEVs被封装在GelMA中通过靶向血小板反应蛋白-1促进糖尿病伤口愈合来促进血管生成
Yan Cong,Sheng Meng,Xiaoye Xie et al.
Yan Cong et al.
Background: Chronic nonhealing wounds are major complications in diabetic patients, with impaired angiogenesis playing a critical role in the delayed healing process. Current treatments for diabetic wounds are inadequate....
A multifunctional injectable ε-poly-L-lysine-loaded sodium-alginate/gelatin hydrogel promotes the healing of infected wounds by regulating macrophage polarization and the skin microbiota [0.03%]
ε-聚-L-赖氨酸负载的多功能可注射钠 alginate/明胶水凝胶通过调节巨噬细胞极化和皮肤微生物群促进感染伤口愈合
Xiaoran Zu,Yudi Han,Yongqiang Zhou et al.
Xiaoran Zu et al.
Background: Infected wounds caused by bacteria such as Escherichia coli and Staphylococcus aureus pose significant challenges during the healing process. Hydrogels have emerged as promising materials for the treatment of ...
Role of damage-associated molecular patterns in the pathogenesis and therapeutics of traumatic brain injury [0.03%]
损伤相关分子模式在创伤性脑损伤发病机制和治疗中的作用
Bowen Sun,Jiarui Zhang,Zhiqiang Li et al.
Bowen Sun et al.
Traumatic brain injury (TBI) is a serious condition that poses a significant threat to human health globally. It is typically caused by direct trauma to the brain due to external forces such as impact or compression. The progression of TBI ...
Adipose mesenchymal stem cell-derived exosomes rescue mitochondrial function through SIRT1 to improve diabetic wound healing [0.03%]
脂肪间充质干细胞衍生的外泌体通过SIRT1挽救线粒体功能以改善糖尿病伤口愈合
Xiaozhi Bai,Yu Li,Peng Wang et al.
Xiaozhi Bai et al.
Background: Diabetic wounds represent the most common type of chronic wounds. Persistent inflammation and elevated oxidative stress are hallmark features of chronic wounds, where macrophage phenotypic polarization playing...
Metal semiconductor materials in bone diseases: properties, applications, and future perspectives [0.03%]
金属半导体材料在骨疾病中的性质、应用和未来展望
Wenshuang Sun,Yizhang Wu,Jia Sha et al.
Wenshuang Sun et al.
The objective of bone tissue engineering is to develop innovative biomaterials and stimulation strategies to promote bone regeneration. Bioelectric materials play a crucial role in this domain owing to their inspiration of the inherent piez...