Yuting Huang,Xiaoyan Wu,Yongxin Xu et al.
Yuting Huang et al.
As the largest organ in the human body, the skin protects the body from pathogens and harmful substances through physical, chemical, and immune barrier functions. However, accurately replicating the complex physiology of human skin in mouse...
Exploring machine learning strategies for single-cell transcriptomic analysis in wound healing [0.03%]
探究机器学习在伤口愈合单细胞转录组分析中的策略
Jianzhou Cui,Mei Wang,Chenshi Lin et al.
Jianzhou Cui et al.
Wound healing is a highly orchestrated, multiphase process that involves various cell types and molecular pathways. Recent advances in single-cell transcriptomics and machine learning have provided unprecedented insights into the complexity...
Linyang Liu,Eugenia Spessot,Khoon S Lim et al.
Linyang Liu et al.
Bioprinting has emerged as a promising technology for fabricating vascularized skin substitutes. The availability of functional skin tissue constructs is critical for the surgical treatment of various wounds, including ulcers and burns. Int...
Targeting oxidative damage in diabetic foot ulcers: integrative strategies involving antioxidant drugs and nanotechnologies [0.03%]
针对糖尿病足溃疡的氧化损伤：抗氧化药物和纳米技术的综合策略
Runze Wang,Bowen Li,Mengchao Dong et al.
Runze Wang et al.
Foot ulcerations in patients with diabetes are common and severe, typically caused by infection and chronic inflammation. Poor blood circulation and neuropathy impair the body's ability to heal wounds effectively, creating a conducive envir...
Flufenamic acid inhibits pyroptosis in ischemic flaps via the AMPK-TRPML1-Calcineurin signaling pathway [0.03%]
氟芬那酸通过AMPK-TRPML1-Calcineurin信号通路抑制缺血皮瓣的pyroptosis
Liang Chen,Ningning Yang,Kongbin Chen et al.
Liang Chen et al.
Background: Ischemic injury is a primary cause of distal flap necrosis. Previous studies have shown that Flufenamic acid (FFA) can reduce inflammation, decrease oxidative stress (OS), and promote angiogenesis, suggesting ...
PANoptosis: a new insight into the mechanism of ischaemia-reperfusion injury [0.03%]
PANoptosis：缺血/再灌注损伤机制的新视野
Huapei Song,Guangping Liang,Fengjun Wang
Huapei Song
Programmed cell death, which occurs via modes such as apoptosis, necroptosis, and pyroptosis, is an important mechanism for host defence against pathogens and inflammation-mediated immune responses. Recently, interactions between various ty...
Review on electrical stimulation combined with electroactive biomaterials to promote peripheral nerve regeneration [0.03%]
电刺激联合导电生物材料促进外周神经再生研究进展评述
Jiahui Song,Zhengchao Yuan,Xiao Yu et al.
Jiahui Song et al.
Peripheral nerve injury results in sensory and motor dysfunction, which is an enormous economic burden for patients and society. Complete recovery of peripheral nerve function after injury is complicated. Utilizing the electrophysiological ...
Three-dimensional composite aerogel scaffolds based on electrospun poly(lactic acid)/gelatin and silica-strontium oxide short fibers promote bone defect healing [0.03%]
基于静电纺聚乳酸/明胶和二氧化硅-氧化锶短纤维的三维复合气凝胶支架促进骨缺损修复
Jie Cui,Lixiang Zhang,Muhammad Shafiq et al.
Jie Cui et al.
Background: Bone defect regeneration is a dynamic healing process that relies on the body's innate repair mechanisms, yet natural healing capacity remains limited. To address this challenge, advanced biomaterials combinin...
Consensus on the Diagnosis and Treatment of Adult Necrotizing Fasciitis (2025 Edition) [0.03%]
成人坏死性筋膜炎诊疗专家共识(2025版)
Ling Zhou,Haisheng Li,Gaoxing Luo;CANF experts group representing the Chinese Burn Association;Editorial Board of the Chinese Journal of Burns and Wounds;Burn Medicine Branch of China
Ling Zhou
Necrotizing fasciitis (NF) is a disease characterized by severe infection of the skin and its underlying soft tissues as the initial symptom. NF is known for its difficulty in early diagnosis and rapid progression. If not treated promptly, ...
Sepsis after trauma-evolving paradigms in stress biology and host response failure [0.03%]
创伤后的感染性休克——压力生物学及宿主反应障碍的变革理论
Petra Dickmann,Ralf A Claus,Michael Bauer
Petra Dickmann
Severe trauma is often complicated by subsequent infection and organ dysfunction, with sepsis being a major mortality risk factor. Factors such as barrier destruction, wound contamination, invasive procedures, injury severity, and shock wer...