FABP7 in Hepatic Macrophages Promotes Fibroblast Activation and CD4+ T-Cell Migration by Regulating M2 Polarization During Liver Fibrosis [0.03%]
肝巨噬细胞中的FABP7通过调节M2极化促进肝纤维化过程中成纤维细胞活化和CD4+T细胞迁移
Hirofumi Miyazaki,Tunyanat Wannakul,Shuhan Yang et al.
Hirofumi Miyazaki et al.
Hepatic macrophages respond to various microenvironmental signals and play a central role in maintaining hepatic homeostasis, dysregulation of which leads to various liver diseases. Fatty acid-binding protein 7 (FABP7), an intracellular lip...
Nucleated Red Blood Cells Secrete Haptoglobin to Induce Immunosuppressive Function in Monocytes [0.03%]
有核红细胞分泌转铁蛋白以诱导单核细胞的免疫抑制功能
Shusuke Takeuchi,Satoshi Fujiyama,Motomichi Nagafuji et al.
Shusuke Takeuchi et al.
Nucleated red blood cells (NRBCs) are precursors of red blood cells (RBCs), but also possess variety of immunomodulatory effects. However, among the three types of NRBCs, the immunological effects of human CD45- NRBCs remain largely unknown...
Risk Allele rs117026326-Mediated Alternative Splicing of GTF2I Promotes B Cell Proliferation in Primary Sjögren's Syndrome [0.03%]
等位基因rs117026326介导的GTF2I可变剪接促进原发性干燥综合征B细胞增殖
Chaowen Luo,Chaofeng Lian,Jinlei Sun et al.
Chaowen Luo et al.
Objectives: Primary Sjögren's syndrome (pSS) is associated with a risk allele T of rs117026326 located at a potential splicing enhancer within the intronic region of general transcription factor II-I (GTF2I). This study aimed to explore th...
Unveiling the Interplay Between Dendritic Cells and Natural Killer Cells as Key Players in Leishmania Infection [0.03%]
揭示树突细胞和自然杀伤细胞在利什曼原虫感染中相互作用的关键地位
Ana Valério-Bolas,Mafalda Meunier,Armanda Rodrigues et al.
Ana Valério-Bolas et al.
Leishmaniasis is a group of parasitic diseases whose etiological agent is the protozoa Leishmania. These diseases afflict impoverished populations in tropical and subtropical regions and affect wild and domestic animals. Canine leishmaniasi...
Durability of Functional SARS-CoV-2-Specific Immunological Memory and T Cell Response up to 8-9 Months Postrecovery From COVID-19 [0.03%]
最长9个月，新冠恢复后功能性SARS-CoV-2特异性免疫记忆和T细胞反应的持续性
Diptee Trimbake,Dharmendra Singh,Yogesh Gurav K et al.
Diptee Trimbake et al.
Research on long-term follow-up in individuals who have recovered from coronavirus disease-19 (COVID-19) would yield insights regarding their immunity status and identify those who need booster vaccinations. This study evaluated the longevi...
Global Trends in Research of Amino Acid Metabolism in T Lymphocytes in Recent 15 Years: A Bibliometric Analysis [0.03%]
过去十五年T淋巴细胞氨基酸代谢研究中的全球趋势：一次文献计量分析
Jiaona Xu,Yinan Yu,Shijie Li et al.
Jiaona Xu et al.
Amino acid metabolism in T cells determines the therapeutic efficacy of T-cell-targeting drugs. To assess the direction of amino acid metabolism in T cells and construct related knowledge structure, we performed a bibliometric analysis aimi...
Lei Han,Tianxiang Wu,Qin Zhang et al.
Lei Han et al.
The body's immune response plays a critical role in defending against external or foreign antigens while also preserving tolerance to self-antigens. This equilibrium, referred to as immune homeostasis, is paramount for overall health. The r...
Advancements and Future Directions of Dual-Target Chimeric Antigen Receptor T-Cell Therapy in Preclinical and Clinical Studies [0.03%]
双特异性CAR-T细胞疗法的研发现状与未来展望
Chenyun Zhang,Haizhou Liu
Chenyun Zhang
In recent years, chimeric antigen receptor T-cell (CAR-T) therapy has made groundbreaking progress in the treatment of various cancer types, particularly hematological malignancies. In the meantime, various preclinical and clinical studies ...
NF- κ B Inhibitory Activity of the Di-Hydroxy Derivative of Piperlongumine (PL-18) [0.03%]
派伯 длинг米因二羟基衍生物(PL-18)的NF-кB抑制活性
Yael Schlichter Kadosh,Subramani Muthuraman,Ariel Kushmaro et al.
Yael Schlichter Kadosh et al.
Inflammation is a critical response of the immune system to infection or injury, serving to repair and restore tissue homeostasis. While acute inflammation generally protects against harmful stimuli, prolonged and chronic inflammation have ...
Roles of NET Peptides With Known Antimicrobial Activity and Toxicity in Immune Response [0.03%]
已知具有抗菌活性和毒性的NET多肽在免疫反应中的作用
Sinan Cebeci,Tuba Polat,Nihan Ünübol
Sinan Cebeci
Antimicrobial peptides (AMPs) are crucial components of the innate immune system in all living organisms, playing a vital role in the body's defense against diseases and infections. The immune system's primary functions include preventing d...