OPN-Derived Peptides Generated by Proteasomes Can Promote Cell Migration via CD44 Activation [0.03%]
蛋白酶体生成的OPN衍生肽可通过激活CD44促进细胞迁移
Hindh Imad,Kathryn E Strange,Chiara Dianzani et al.
Hindh Imad et al.
Osteopontin (OPN) is a pleiotropic cytokine that is overexpressed in many autoimmune diseases and solid cancers. Here we show that the 20S proteasome can degrade, in vitro, both the full-length OPN and the OPN-C fragment generated in the ex...
CAR-Cell Therapy for Autoimmune Diseases: From the Laboratory to Clinical Practice [0.03%]
CAR-T细胞治疗自身免疫病：从实验室到临床
Xiao-Peng Zhang,Yi-Dong Chen,Qi Yu et al.
Xiao-Peng Zhang et al.
Autoimmune diseases (AIDs) are characterized by a breakdown in immune tolerance, wherein the patient's immune system fails to recognize self-tissues and subsequently attacks the body's organs and tissues. Although there are many therapeutic...
RETRACTION: Anti-Inflammatory and Healing Activity of the Hydroalcoholic Fruit Extract of Solanum diploconos (Mart.) Bohs [0.03%]
撤稿：Solanum diploconos（Mart.）Bohs水果的氢醇提取物的抗炎和愈合作用
Journal Of Immunology Research
Journal Of Immunology Research
The Role of IFN-γ-Mediated Immune Cell Crosstalk in the Pathogenesis of Aplastic Anemia [0.03%]
IFN-γ介导的免疫细胞相互作用在再生障碍性贫血发病机制中的作用
Shuai Tan,Yumeng Li,Yaochi Chen et al.
Shuai Tan et al.
Interferon-gamma (IFN-γ) is a central mediator of immune-driven bone marrow failure (BMF) in acquired aplastic anemia (AA). Persistent IFN-γ signaling alters the bone marrow microenvironment by activating the JAK-STAT1 pathway, which resu...
Runmin Ding,Zexin Yang,Yuxi Chen et al.
Runmin Ding et al.
Fibrosis refers to the scarring and hardening of tissue resulting from the excessive deposition of extracellular matrix (ECM) proteins by myofibroblasts during chronic inflammatory responses, which can ultimately lead to organ failure and p...
Systematic Analysis of Peripheral Immune Signatures and Diagnostic Model Construction in Patients With Uterine Fibroids [0.03%]
系统分析子宫肌瘤患者的外周免疫特征并构建诊断模型
Pei-Xian Li,Si-Fei Yu,Yu-Bin Han et al.
Pei-Xian Li et al.
Objective: To systematically characterize the peripheral immune signature of uterine fibroids (UFs) and to develop a diagnostic model for differentiating UF patients from healthy individuals, thereby providing new insight...
A Comprehensive Review of AIM2 in Cancer: Functional Roles, Molecular Pathways, and Clinical Relevance [0.03%]
AIM2在癌症中的全面回顾：功能作用、分子通路和临床相关性
Nuo Wang,Shaoxian Wu,Zhang Fang et al.
Nuo Wang et al.
Inflammation has been recognized as a component of cancer progression, and inflammasome receptor components also regulate various biological processes, including cell proliferation, gene transcription, and tumorigenesis. Accumulating eviden...
RETRACTION: Circular RNA RHOT1 Regulates miR-142-5p/CCND1 to Participate in Chondrocyte Autophagy and Proliferation in Osteoarthritis [0.03%]
撤稿：环状RNA RHOT1通过调节miR-142-5p/CCND1参与骨关节炎软骨细胞自噬和增殖
Journal Of Immunology Research
Journal Of Immunology Research
Intermittent Tacrolimus Treatment Delays CD8+ Tumor-Infiltrating Lymphocyte Exhaustion and Enhances PD1 Blockade Therapy in Melanoma-Bearing Mice [0.03%]
间歇性他克莫司治疗延缓CD8+t细胞衰竭和增强小鼠黑色素瘤PD1阻断疗法
Darong Chen,Sisi Feng,Zhaolong Chen et al.
Darong Chen et al.
Continuous antigen exposure initiates the developmental process of CD8+ T cell exhaustion, accompanied by a gradual increase in the expression of inhibitory receptors (IRs). Our previous study conceptualized T cell exhaustion as an over-act...
The Traditional Chinese Medicine Compound Hezi Qingyou Formula Controls the MAPK Signaling Pathway for Alleviating Gastric Ulcer Induced by Acetic Acid in Rats [0.03%]
诃子青犹方通过调控MAPK信号途径减轻醋酸诱导的大鼠胃溃疡症状
Zhong Feng,Ruixia Wei,Junhao Tian et al.
Zhong Feng et al.
In clinical practice, Hezi Qingyou Formula (HZQYF) has been observed to effectively alleviate clinical symptoms associated with gastri ulcers, though its precise mechanism of action remains unclear. To investigate the effects of HZQYF on ga...