Develop a Novel Signature to Predict the Survival and Affect the Immune Microenvironment of Osteosarcoma Patients: Anoikis-Related Genes [0.03%]
开发一种新型标志物以预测骨肉瘤患者的生存率并影响免疫微环境： anoikis相关基因
Mingyi Yang,Yani Su,Ke Xu et al.
Mingyi Yang et al.
Objective: Osteosarcoma (OS) represents a prevalent primary bone neoplasm predominantly affecting the pediatric and adolescent populations, presenting a considerable challenge to human health. The objective of this invest...
Serum Levels of Selected Cytokines and Chemokines and IgG4 in Children With Recurrent Respiratory Tract Infections [0.03%]
儿童反复呼吸道感染患者血清中选定细胞因子、趋化因子及IgG4水平变化
Edyta Machura,Helena Krakowczyk,Magdalena Kleszyk et al.
Edyta Machura et al.
Background: Respiratory tract infections are a common health problem. Cytokines/chemokines play a critical role in the regulation of the immune system. Their defective production may predispose to recurrent respiratory tract infections (RRI...
The Causal Relationship between Immune-Mediated Inflammatory Diseases and Aortic Aneurysm: A Bidirectional Two-Sample Mendelian Randomization Study [0.03%]
基于两样本孟德尔随机化研究探讨免疫介导性炎症性疾病与主动脉瘤的因果关联性
Sijia Sun,Jie Li,Mengxian Sun et al.
Sijia Sun et al.
Methods: We sourced genetic association data from public genome-wide association study databases for populations of European ancestry. Adhering to MR principles, we identified valid instrumental variables from genetic var...
Studying the Humoral Response against SARS-CoV-2 in Cuban COVID-19 Recovered Patients [0.03%]
古巴新冠肺炎康复患者的血清学研究
Ivette Orosa Vázquez,Marianniz Díaz,Yaima Zúñiga Rosales et al.
Ivette Orosa Vázquez et al.
Understanding the immune response generated by SARS-CoV-2 is critical for assessing efficient therapeutic protocols and gaining insights into the durability of protective immunity. The current work was aimed at studying the specific humoral...
Moxibustion Regulates the BRG1/Nrf2/HO-1 Pathway by Inhibiting MicroRNA-222-3p to Prevent Oxidative Stress in Intestinal Epithelial Cells in Ulcerative Colitis and Colitis-Associated Colorectal Cancer [0.03%]
温灸通过抑制微小核糖核酸-222-3ｐ调控ＢＲＧ1／Ｎｒｆ2／ＨＯ-１信号通路防治溃疡性结肠炎及其相关结直肠癌氧化应激损伤
Xuejun Wang,Haiyang Ji,Yanting Yang et al.
Xuejun Wang et al.
Oxidative stress is crucial in ulcerative colitis (UC) and colitis-associated colorectal cancer (CAC). Intestinal epithelial cells (IECs) are an important component of the intestinal barrier. In previous studies, we have demonstrated that s...
Elevated Proportions of Circulating CXCR5+ Follicular Helper T Cells Reflect the Presence of Airway Obstruction in Asthma [0.03%]
循环CXCR5+滤泡辅助性T细胞比例升高反映哮喘患者气道阻塞的存在
Tsukie Kin Tsukuda,Kimiko Tsuji,Akari Nishimori et al.
Tsukie Kin Tsukuda et al.
Materials and methods: Using flow cytometry, we identified and quantified Group 2 innate lymphocytes, T helper 2 cells, follicular helper T cells, and T helper 17 cells in peripheral blood samples from 49 individuals with...
The Potential Impact of HNRNPA2B1 on Human Cancers Prognosis and Immune Microenvironment [0.03%]
HNRNPA2B1对人类癌症预后和免疫微环境的潜在影响
Tao Huang,Gang Zhu,Fan Chen
Tao Huang
HNRNPA2B1 is a member of the HNRNP family, which is associated with telomere function, mRNA translation, and splicing, and plays an important role in tumor development. To date, there have been no pan-cancer studies of HNRNPA2B1, particular...
miR-214-3p Deficiency Enhances Caspase-1-Dependent Pyroptosis of Microglia in White Matter Injury [0.03%]
miR-214-3p缺乏通过依赖Caspase-1的途径增强少突胶质细胞前体细胞焦亡在白质损伤中的作用研究
Liufang He,Tingyan Wei,Yong Huang et al.
Liufang He et al.
White matter injury (WMI) is the most frequent impairment of neurodevelopment in preterm infants. Here, we report that the caspase-1 inflammasome is abundantly activated in the microglia of WMI mice and results in increased pyroptosis of mi...
The Potential of Single-Chain Variable Fragment Antibody: Role in Future Therapeutic and Diagnostic Biologics [0.03%]
单链可变片段抗体的潜力：未来生物药物治疗和诊断的作用
Getachew Gezehagn Kussia,Tesfaye Sisay Tessema
Getachew Gezehagn Kussia
The advancement of genetic engineering has revolutionized the field of immunology by allowing the utilization of intrinsic antibody structures. One of the biologics that are being produced by recombinant antibody technology is single-chain ...
Taz/Tead1 Promotes Alternative Macrophage Activation and Kidney Fibrosis via Transcriptional Upregulation of Smad3 [0.03%]
Taz/Tead1通过Smad3的转录上调促进替代性巨噬细胞活化和肾纤维化
Yizhi Ren,Lu Zhou,Xinyuan Li et al.
Yizhi Ren et al.
Macrophage alternative activation is involved in kidney fibrosis. Previous researches have documented that the transcriptional regulators Yes-associated protein (Yap)/transcriptional coactivator with PDZ-binding motif (Taz) are linked to or...