OPN-Derived Peptides Generated by Proteasomes Can Promote Cell Migration via CD44 Activation
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Osteopontin (OPN) is a pleiotropic cytokine that is overexpressed in many autoimmune diseases and solid cancers. Here we show that the 20S proteasome can degrade, in vitro, both the full-length OPN and the OPN-C fragment generated in the extracellular space an... ...
