Mark D Long,Moray J Campbell
Mark D Long
Nuclear receptors (NR) act as an integrated conduit for environmental and hormonal signals to govern genomic responses, which relate to cell fate decisions. We review how their integrated actions with each other, shared co-factors and other...
Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism [0.03%]
视黄酸相关孤儿受体(RORs):在免疫、发育、昼夜节律及代谢中的调节功能
Donald N Cook,Hong Soon Kang,Anton M Jetten
Donald N Cook
In this overview, we provide an update on recent progress made in understanding the mechanisms of action, physiological functions, and roles in disease of retinoic acid related orphan receptors (RORs). We are particularly focusing on their ...
An Zou,Sarah Lehn,Nancy Magee et al.
An Zou et al.
Small heterodimer partner (SHP; NR0B2) is a unique orphan nuclear receptor (NR) that contains a putative ligand-binding domain but lacks a DNA-binding domain. SHP is a transcriptional corepressor affecting diverse metabolic processes includ...
IDENTIFICATION OF VDR ANTAGONISTS AMONG NUCLEAR RECEPTOR LIGANDS USING VIRTUAL SCREENING [0.03%]
基于虚拟筛选的核受体配体鉴定维生素D受体拮抗剂研究
Kelly Teske,Premchendar Nandhikonda,Jonathan W Bogart et al.
Kelly Teske et al.
Herein, we described the development of two virtual screens to identify new vitamin D receptor (VDR) antagonists among nuclear receptor (NR) ligands. Therefore, a database of 14330 nuclear receptor ligands and their NR affinities was assemb...