Michael S Salomon,S Harshini Malapati,Jerry O&#x; Dwyer et al.
Michael S Salomon et al.
The thyroid hormone receptor (TR) is essential for the proper regulation of metabolism and development, as it regulates gene expression in response to thyroid hormone. Nuclear localization signals (NLSs) and nuclear export signals (NESs) al...
Phase 0 of the Xenobiotic Response: Nuclear Receptors and Other Transcription Factors as a First Step in Protection from Xenobiotics [0.03%]
外来物质反应的第0相：核受体及其他转录因子是保护机体免受外来物质侵害的第一道防线
William S Baldwin
William S Baldwin
This mini-review examines the crucial importance of transcription factors as a first line of defense in the detoxication of xenobiotics. Key transcription factors that recognize xenobiotics or xenobiotic-induced stress such as reactive oxyg...
Qinglin Yang,Qinqiang Long
Qinglin Yang
The nuclear receptor peroxisome proliferator-activated receptor δ (PPARδ) can transcriptionally regulate target genes. PPARδ exerts essential regulatory functions in the heart, which requires constant energy supply. PPARδ plays a key ro...
Structural and Dynamic Elucidation of a Non-acid PPAR γ Partial Agonist: SR1988 [0.03%]
非酸性PPARγ部分激动剂SR1988的结构和动态阐释
Rebecca L Frkic,Benjamin S Chua,Youseung Shin et al.
Rebecca L Frkic et al.
Targeting peroxisome proliferator-activated receptor γ (PPARγ) by synthetic compounds has been shown to elicit insulin sensitising properties in type 2 diabetics. Treatment with a class of these compounds, the thiazolidinediones (TZDs), h...
Regulation of Microbiota by Vitamin D Receptor: A Nuclear Weapon in Metabolic Diseases [0.03%]
维生素D受体调节微生物群在代谢性疾病中的作用：一把核武器
Danika Bakke,Ishita Chatterjee,Annika Agrawal et al.
Danika Bakke et al.
Metabolic syndrome is a multi-faceted disease. The microbiota, as a newly discovered organ, contributes to the pathogenesis and progression of metabolic syndrome. Recent studies have demonstrated that nuclear receptors play critical roles i...
The Role of Glucocorticoid Receptors in Podocytes and Nephrotic Syndrome [0.03%]
肾小球足细胞上糖皮质激素受体的作用及其在肾病综合征中的意义
Xuan Zhao,Daw-Yang Hwang,Hung-Ying Kao
Xuan Zhao
Glucocorticoid receptor (GC), a founding member of the nuclear hormone receptor superfamily, is a glucocorticoid-activated transcription factor that regulates gene expression and controls the development and homeostasis of human podocytes. ...
Rebecca A Lee,Charles A Harris,Jen-Chywan Wang
Rebecca A Lee
Glucocorticoids are steroid hormones that play a key role in metabolic adaptations during stress, such as fasting and starvation, in order to maintain plasma glucose levels. Excess and chronic glucocorticoid exposure, however, causes metabo...
Chris R Gissendanner,William S Baldwin,Marcel J M Schaaf
Chris R Gissendanner
Gisela I Mazaira,Nadia R Zgajnar,Cecilia M Lotufo et al.
Gisela I Mazaira et al.
In this article we summarize the birth of the field of nuclear receptors, the discovery of untransformed and transformed isoforms of ligand-binding macromolecules, the discovery of the three-domain structure of the receptors, and the proper...
Nuclear Receptor SHP: A Critical Regulator of miRNA and lncRNA Expression and Function [0.03%]
核受体SHP：miRNA和长链非编码RNA表达及功能的重要调节因子
Yongfeng Song,Shan Lu,Jiajun Zhao et al.
Yongfeng Song et al.
Small heterodimer partner (SHP, NR0B2) is identified as a unique orphan nuclear receptor that acts as a transcriptional repressor. SHP plays a crucial role in the control of various physiological processes and in several diseases by regulat...