Role of Farnesoid X Receptor in the Determination of Liver Transcriptome during Postnatal Maturation in Mice [0.03%]
法尼醇X受体在小鼠出生后肝转录组成熟中的作用
Lai Peng,Stephanie C Piekos,Grace L Guo et al.
Lai Peng et al.
The liver is a vital organ with critical functions in metabolism of various biologically useful materials, synthesis of several vital proteins, detoxification of toxic substances, and immune defense. Most liver functions are not mature at b...
PPARs: Key Regulators of Airway Inflammation and Potential Therapeutic Targets in Asthma [0.03%]
PPARs：调控气道炎症的关键因素及哮喘的潜在治疗靶点
Asoka Banno,Aravind T Reddy,Sowmya P Lakshmi et al.
Asoka Banno et al.
Asthma affects approximately 300 million people worldwide, significantly impacting quality of life and healthcare costs. While current therapies are effective in controlling many patients' symptoms, a large number continue to experience exa...
Shari Bodofsky,Francine Koitz,Bruce Wightman
Shari Bodofsky
The nuclear receptor gene family includes 18 members that are broadly conserved among multiple disparate animal phyla, indicating that they trace their evolutionary origins to the time at which animal life arose. Typical nuclear receptors c...
BINDING SITE ANALYSIS OF THE CAENORHABDITIS ELEGANS NR4A NUCLEAR RECEPTOR NHR-6 DURING DEVELOPMENT [0.03%]
NR4A核受体NHR-6在发育过程中的结合位点分析
Brandon Praslicka,Jeremy S Harmson,Joohyun Kim et al.
Brandon Praslicka et al.
Members of the NR4A subfamily of nuclear receptors make up a highly conserved, functionally diverse group of transcription factors implicated in a multitude of cellular processes such as proliferation, differentiation, apoptosis, metabolism...
MUTATIONS IN LIVER X RECEPTOR ALPHA THAT IMPAIR DIMERIZATION AND LIGAND DEPENDENT TRANSACTIVATION [0.03%]
影响同源二聚作用和配体诱导的转激活作用的肝脏X受体α突变体
Shimpi Bedi,Heather A Hostetler,Stanley Dean Rider Jr
Shimpi Bedi
Liver X receptor alpha (LXRα) is crucial for the maintenance of lipid and cholesterol homeostasis. Ligand binding and dimerization with retinoid X receptor (RXR) or peroxisome proliferator-activated receptor (PPAR) is required for forming ...
Annotation of the Nuclear Receptors in an Estuarine Fish species, Fundulus heteroclitus [0.03%]
一种河口鱼类杀鱼属潮蟹鱼（学名）的核受体注释
William S Baldwin,W Tyler Boswell,Gautam Ginjupalli et al.
William S Baldwin et al.
The nuclear receptors (NRs) are ligand-dependent transcription factors that respond to various internal as well as external cues such as nutrients, pheromones, and steroid hormones that play crucial roles in regulation and maintenance of ho...
Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity [0.03%]
外来物质受体介导的肠道屏障功能和先天免疫调节
Harmit S Ranhotra,Kyle L Flannigan,Martina Brave et al.
Harmit S Ranhotra et al.
The molecular basis for the regulation of the intestinal barrier is a very fertile research area. A growing body of knowledge supports the targeting of various components of intestinal barrier function as means to treat a variety of disease...
Regulation of Drug Disposition Gene Expression in Pregnant Mice with Car Receptor Activation [0.03%]
卡受体激活对怀孕小鼠药代动力学基因表达的调节作用研究
Amanda S Bright,Guadalupe Herrera-Garcia,Jamie E Moscovitz et al.
Amanda S Bright et al.
More than half of pregnant women use prescription medications in order to maintain both maternal and fetal health. The constitutive androstane receptor (Car) critically affects the disposition of chemicals by regulating the transcription of...
Satyanarayana R Pondugula,Petr Pavek,Sridhar Mani
Satyanarayana R Pondugula
Pregnane X receptor (PXR) is an adopted orphan nuclear receptor that is activated by a wide-range of endobiotics and xenobiotics, including chemotherapy drugs. PXR plays a major role in the metabolism and clearance of xenobiotics and endobi...
Nuclear Receptors in Drug Metabolism, Drug Response and Drug Interactions [0.03%]
核受体在药物代谢、药效和药物相互作用中的作用
Chandra Prakash,Baltazar Zuniga,Chung Seog Song et al.
Chandra Prakash et al.
Orally delivered small-molecule therapeutics are metabolized in the liver and intestine by phase I and phase II drug-metabolizing enzymes (DMEs), and transport proteins coordinate drug influx (phase 0) and drug/drug-metabolite efflux (phase...