Identification and Validation of Immune Implication of R-Spondin 1 and an R-Spondin 1-Related Prognostic Signature in Esophagus Cancer [0.03%]
R-spondin 1及其相关预后标志物在食管癌免疫中的作用鉴定与验证
Yuansheng Lin,Xinqi Lou,Shengjun Li et al.
Yuansheng Lin et al.
R-spondin 1 (RSPO1), which encodes a secretory-activating protein, is a promising therapeutic target for various tumors. The aim of this study was to establish a robust RSPO1-related signature specific to esophageal cancer (ESCA). Our compr...
Single-Cell RNA Sequencing Identifies Crucial Genes Influencing the Polarization of Tumor-Associated Macrophages in Liver Cancer [0.03%]
单细胞RNA测序识别出影响肝癌相关巨噬细胞极化的关键基因
Kedong Xu,Mingyi Dong,Zhengqiang Wu et al.
Kedong Xu et al.
Background: In the context of hepatocellular carcinoma (HCC), tumor-associated macrophages (TAMs) are pivotal for the immunosuppressive nature of the tumor microenvironment (TME). This investigation delves into the functi...
Pancreatitis as a Main Consequence of APOC2-Related Hypertriglyceridemia: The Role of Nonsense and Frameshift Variants [0.03%]
APOC2相关高甘油三酯血症性胰腺炎的病因及无义和移码突变的作用
Bahareh Rabbani,Mohadeseh Aghli Moghadam,Shiva Esmaeili et al.
Bahareh Rabbani et al.
APOC2-related hypertriglyceridemia occurs due to biallelic variants of this gene. Here, genotype-phenotype architecture of all pathogenic APOC2 variants is investigated among heterozygous and homozygous individuals. Clinical heterogeneity o...
Zheng Wang,Xiaofang Zhang,Rui Hou et al.
Zheng Wang et al.
Pod dehiscence brings much loss for modern agricultural production, and multiple pod dehiscence components have been identified in many plant species. However, the pod dehiscence regulation factors in soybean are limited. In this study, we ...
A Chromosomal-Level Genome of Dermatophagoides farinae, a Common Allergenic Mite Species [0.03%]
粉尘螨染色体水平基因组
Rongxuan Hu,Haifeng Huang,Ying Zhou et al.
Rongxuan Hu et al.
Background: Genome data have been used to find novel allergen from house dust mites. Here, we aim to construct a chromosome-level genome assembly of Dermatophagoides farinae, a common allergenic mite species. ...
Complete Genome Sequence Analysis of Bacillus subtilis MC4-2 Strain That against Tobacco Black Shank Disease [0.03%]
一株烟草黑胫病拮抗芽孢杆菌Bs_Mc4-2的全基因组序列分析
Chunlan Shi,Shuquan Zeng,Xi Gao et al.
Chunlan Shi et al.
The MC4-2 bacterium strain was isolated and purified from the Periplaneta americana intestine as a biocontrol agent with good antagonistic effect against the pathogens of a soil-borne disease called tobacco black shank. The MC4-2 strain was...
Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 3 Expression and Its Correlation with Prognosis and Growth of Serous Ovarian Cancer: Correlation of DYRK3 with Ovarian Cancer Survival [0.03%]
双特异性酪氨酸磷酸化调节的激酶3在浆液性卵巢癌中的表达及其与预后和生长的关系：DYRK3与卵巢癌生存的关系
Jia Sun,Yingzi Zhang,Aijie Li et al.
Jia Sun et al.
Background: Epithelial ovarian cancer, primarily serous ovarian cancer (SOC), stands as a predominant cause of cancer-related mortality among women globally, emphasizing the urgent need for comprehensive research into its...
Pangenome Analysis of Helicobacter pylori Isolates from Selected Areas of Africa Indicated Diverse Antibiotic Resistance and Virulence Genes [0.03%]
来自非洲特定地区的幽门螺旋杆菌分离株的泛基因组分析表明了多样化的抗生素耐药性和毒力基因
Biigba Yakubu,Edwin Moses Appiah,Andrews Frimpong Adu
Biigba Yakubu
The challenge facing Helicobacter pylori (H. pylori) infection management in some parts of Africa is the evolution of drug-resistant species, the lack of gold standard in diagnostic methods, and the ineffectiveness of current vaccines again...
A Novel Splicing Mutation Leading to Wiskott-Aldrich Syndrome from a Family [0.03%]
导致WAS综合征的一个新型剪接突变
Lingyu Wang,Jie Zhang,Linna Lu et al.
Lingyu Wang et al.
Wiskott-Aldrich syndrome (WAS) is a rare X-linked recessive genetic disease characterized by clinical symptoms such as eczema, thrombocytopenia with small platelets, immune deficiency, prone to autoimmune diseases, and malignant tumors. Thi...
Overexpression of FERM Domain Containing Kindlin 2 (FERMT2) in Fibroblasts Correlates with EMT and Immunosuppression in Gastric Cancer [0.03%]
成纤维细胞中含FERM结构域的Kindlin-2(FERMT2)过表达与胃癌中的上皮间质转化和免疫抑制相关
Sheng-Yan Yin,Yuan-Jie Liu,Jie-Pin Li et al.
Sheng-Yan Yin et al.
The mesenchymal feature, dominated by epithelial mesenchymal transition (EMT) and stromal cell activation, is one of the main reasons for the aggressive nature of tumors, yet it remains poorly understood. In gastric cancer (GC), the fermiti...