Construction of a Mitochondria-Related Gene Diagnostic Model Based on Integrated Multiomics Data and Functional Validation of ANK2 as a Key Regulator in Colorectal Cancer [0.03%]
基于整合多组学数据的线粒体相关基因诊断模型构建及ANK2功能验证：结直肠癌中的关键调控基因
Xiangyu Ding,Huanhuan Wu,Jiyuan Yang et al.
Xiangyu Ding et al.
Colorectal cancer (CRC) is one of the most common malignancies of the digestive tract globally, characterized by high incidence, difficulty in early diagnosis, and poor prognosis. Traditional screening methods have limitations in sensitivit...
Design and Validation of a Predictive Model for Hepatocellular Carcinoma Based on Genes With Differential Expression Driven by DNA Methylation [0.03%]
基于DNA甲基化驱动的差异表达基因的肝细胞癌预测模型的设计与验证
Geyang Hu,Liang Zhou,Jie Zhang et al.
Geyang Hu et al.
Background: Hepatocellular carcinoma (HCC) ranks among the world's most lethal cancers, with the majority of cases diagnosed at advanced stages. Accurate prognostic assessment is therefore essential for HCC management. Th...
Antimicrobial Resistant Factors in Klebsiella pneumoniae Strains Isolated From Urinary Tract Infections, Wound Infections, Hospital Wastewater, and Cervical Cancers From Ghana, Togo, and Benin [0.03%]
加纳、多哥和贝宁尿路感染、伤口感染、医院污水及宫颈癌中分离的肺炎克雷伯菌的耐药因子
Biigba Yakubu
Biigba Yakubu
Klebsiella pneumoniae is a Gram-negative, facultatively anaerobic member of the Enterobacteriaceae that functions both as a gut commensal and a major opportunistic pathogen implicated in severe hospital and community-acquired infections. Th...
Integrative Multiomics Nominate GGCT as a Crucial Regulator of Immunosuppression in Colorectal Cancer [0.03%]
整合多组学分析提名GGCT为结直肠癌免疫抑制的关键调节因子
Qichao Niu,Yang Liu,Kejin Huang et al.
Qichao Niu et al.
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with tumor microenvironment (TME) heterogeneity playing a critical role in disease progression and therapeutic response. Immune escape (IE) mechanisms fa...
Mechanism of Non-Small Cell Lung Cancer-Derived Extracellular Vesicle miRNA hsa-let-7b-5p Targeting AP1S1 to Regulate M2 Macrophage Polarization [0.03%]
非小细胞肺癌来源外泌体中miRNA hsa-let-7b-5p靶向AP1S1调控M2型巨噬细胞极化的机制研究
Lijuan Liu,Zixing Kou,Tianhua Wang et al.
Lijuan Liu et al.
Background: Non-small cell lung cancer (NSCLC) accounts for over 80% of lung cancer cases. Further, the complex tumor immune microenvironment (TIME) is a critical factor in treatment resistance and poor prognosis associat...
Integrative Bioinformatics and Machine Learning Identify Novel Diagnostic Biomarkers and Molecular Mechanisms in Sjögren's Syndrome [0.03%]
整合生物信息学和机器学习识别Sjögren综合征的新诊断生物标志物和分子机制
Hua Xu,Yong Liu,Yuyin Song et al.
Hua Xu et al.
Background: Sjögren's syndrome (SS) is a chronic autoimmune disorder characterized by significant diagnostic challenges due to nonspecific symptoms and a lack of reliable biomarkers, often resulting in delayed diagnosis ...
Single-Cell RNA-seq Reveals Deubiquitination Genes as Prognostic Markers in Hepatocellular Carcinoma [0.03%]
单细胞RNA测序揭示了肝细胞癌中的去泛素化基因预后标志物发现
Xuening Lv,Chaozhou Chen,Shuxian Zhang et al.
Xuening Lv et al.
Background: Hepatocellular carcinoma (HCC) carries a dismal prognosis, yet the contribution of deubiquitination-an essential posttranslational regulator-to its progression remains poorly defined. ...
Pancancer Analyses of KISS1 as a Potential Biomarker for Tumor Metastasis and Immunotherapy and Therapeutic Target for Breast Cancer [0.03%]
泛癌分析Kiss1作为肿瘤转移和免疫治疗的潜在生物标志物及乳腺癌治疗靶点的研究
Chunbiao Wu,Hao Jiang,Wei Xu et al.
Chunbiao Wu et al.
Emerging evidence highlights the pivotal role of KISS1 in cancer metastasis; however, there remains a dearth of pancancer analyses, particularly concerning immunotherapy. Here, we conducted a comprehensive investigation of KISS1 across vari...
Identification of Two Rare Variants in Iranian Families With Familial Sudden Cardiac Death [0.03%]
伊朗家族性突发性心脏死亡患者中罕见变异的识别
Mahsa Tahmasebivand,Sepideh Mehvari,Fatemeh Ghodratpour et al.
Mahsa Tahmasebivand et al.
Cellular action potential is characterized by a particular sequence of depolarizing and repolarizing ion currents regulated by ion channels. Genetic mutations in these channels disrupt the essential movement of ions, such as Na+, Ca++, and ...
Advancing Prognosis Prediction and Immunotherapy Efficacy in Lung Adenocarcinoma Through Machine Learning: Novel Insights From Anoikis Regulator Patterns in Single-Cell Multiomics [0.03%]
通过机器学习推进肺癌腺癌预后预测和免疫治疗疗效：单细胞多组学中 anoikis 调节模式的新见解
Shan Li,Wenhang Zhou,Chen Hu et al.
Shan Li et al.
Introduction: Anoikis, a type of programmed cell death induced by detachment from the extracellular matrix (ECM), is crucial in cancer progression. Resistance to anoikis often correlates with enhanced invasion, metastasis...