Single-Cell Transcriptomics Reveals Dynamic Cellular Interactions and Molecular Mechanisms in Myocardial Infarction Recovery [0.03%]
单细胞转录组揭示心肌梗死后动态细胞相互作用及分子机制
Jianfeng Zhao,Junhui Gong,Cunzhi Zhu
Jianfeng Zhao
Background: Repair and remodeling following myocardial infarction (MI) are complex processes with a wide array of cellular and molecular mechanisms; however, the cell source mediating repair is still poorly understood in ...
Causal Effects of Yogurt Intake on Gut Microbiota: A European Mendelian Randomization Study [0.03%]
基于欧洲人群的孟德尔随机化研究揭示酸奶摄入对肠道菌群的因果效应
Mengqi Yang,Liping Wang,Peng Zhou et al.
Mengqi Yang et al.
Background: Yogurt is reported to maintain the balance of gut microbiota and prevent disease, but the causal relationship remains unclear. Methods: ...
Integrated Transcriptomic Analysis Identifies Immune Remodeling and Prognostic Signatures in Uveal Melanoma [0.03%]
整合转录组分析确定葡萄膜黑色素瘤中的免疫重塑和预后标志物
Zhongmin Li,Youmeng Yang,Houhong Wang et al.
Zhongmin Li et al.
Background: Uveal melanoma (UVM) is the most common primary intraocular malignancy in adults and exhibits a high propensity for liver metastasis, often leading to poor prognosis. However, effective prognostic biomarkers a...
Extracellular Matrix-Associated Biomarkers for Hepatocellular Carcinoma: Insights From Machine Learning and Single-Cell Analysis [0.03%]
机器学习和单细胞分析揭示的肝细胞癌相关细胞外基质生物标志物
Pedram Asadi Sarabi,Elham Rismani,Amir Ali Judaki et al.
Pedram Asadi Sarabi et al.
The 5-year overall survival rate for hepatocellular carcinoma (HCC) patients remains below 20%. Alterations in the extracellular matrix (ECM) are increasingly recognized as central drivers of HCC initiation and progression. This study appli...
m5C: Novel Diagnostic and Drug Repurposing Targets for Nonalcoholic Steatohepatitis [0.03%]
NASH中m5C的诊断与药物重定位研究
Shuxian Chen,Renquan Duan,Jingyi Qiu et al.
Shuxian Chen et al.
Background: Epigenetic medication, such as RNA 5-methylcytosine (m5C), is well-recognized as a key regulator in hepatic metabolism and immune responses. However, m5C regulatory mechanisms in NASH pathogenesis have not yet...
Circulating Metabolic Factors Mediating the Effect of Obesity-Related Indicators on Meniscal Injuries: A Mendelian Randomization Study [0.03%]
肥胖相关指标对半月板损伤影响的介导因素的孟德尔随机化研究
Dong Ye,Zhiping Zhang,Jun Zhang
Dong Ye
Background: Meniscal injuries and obesity are major global public health problems. The Mendelian randomization approach can overcome the limitations of traditional observational study designs with respect to confounding a...
Epigenetics in B-CLL [0.03%]
B-CLL中的表观遗传学问题
Alexandra Chu,Flavia Soto,Rodrigo Hurtado et al.
Alexandra Chu et al.
B-cell chronic lymphocytic leukemia (B-CLL) is the most common hematological malignancy in adults. Its clinical course is heterogeneous, ranging from indolent forms with slow progression to aggressive variants refractory to conventional tre...
Establishment of a m6A-Related Molecular Pattern in the Prognosis and Immune Infiltration of Osteosarcoma Using Machine Learning and Experiments [0.03%]
基于机器学习和实验的骨肉瘤m6A相关分子模式的建立及其在预后和免疫浸润中的作用研究
Na He,Xia Chen,Chunyan Zhang
Na He
Background: To determine the prognosis of osteosarcoma, multiple predictive models have been constructed in recent years. Nevertheless, the model for N6-methyladenosine (m6A)-related genes, a critical subset of molecular ...
IER3 Promotes Malignant Progression of Colorectal Cancer Through the NF- κ B Pathway [0.03%]
IER3通过NF- κ B途径促进结直肠癌恶性进展
Zhigang Wei,Yinyi Luo,Yupeng Zhang et al.
Zhigang Wei et al.
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, primarily due to metastatic progression and an immunosuppressive tumor immune microenvironment (TIME). The stress-responsive gene IER3 is found to be dys...
Multi-Omics Evidence Based on Spatial Transcriptomics Data Reveals the Therapeutic Value of Copper Death Genes in Glioblastoma [0.03%]
基于空间转录组学数据的多组学证据揭示铜死亡基因在胶质母细胞瘤治疗中的价值
Zhaoliang Xue,Zhengfei Song,Lianjie Mo et al.
Zhaoliang Xue et al.
Background: Cuprotosis is an emerging form of copper-dependent programmed cell death, while low-grade gliomas (LGGs) represent a common subtype of primary brain tumors. ...