Single-Cell Analysis Delineates Glutathione Metabolism-Related Gene Signatures in the Glioblastoma Microenvironment and Identifies GSTA4 as a Regulator of Malignant Behaviors [0.03%]
单细胞分析确定胶质母细胞瘤微环境中与谷胱甘肽代谢相关的基因特征并鉴定GSTA4为恶性行为调节因子
Baozhi Feng,Jie Wang,Wei Shang et al.
Baozhi Feng et al.
Background and objective: The cellular distribution characteristics and functional mechanisms of glutathione (GSH) metabolism within the tumor microenvironment (TME) of glioblastoma multiforme (GBM) remain poorly understo...
Immune Cell-Mediated Retinoblastoma Development: Genetic and Molecular Mechanisms [0.03%]
免疫细胞介导的视网膜母细胞瘤发生发展的遗传及分子机制研究
Xinyang Hu,Jingqiu Li,Jinhong Li et al.
Xinyang Hu et al.
Retinoblastoma (RB) is the most prevalent malignant tumor that originates within the eye in children, occurring at a frequency of around 1:20,000 to 1:15,000. RB typically occurs when both alleles of the retinoblastoma 1 (RB1) gene are deac...
A Multiomics and Bioinformatics Analysis of the Role and Mechanism of CNKSR1 in Ovarian Cancer Progression [0.03%]
CNKSR1在卵巢癌进展中的作用和机制的多组学与生物信息学分析
Weili Zhu,Yimin Huang,Jiayue Huang et al.
Weili Zhu et al.
This study aims to utilize multiomics and bioinformatics techniques to investigate the expression of the connection enzyme inhibitor Ras1 1 (CNKSR1) in ovarian cancer (OC) and its mechanism of action in the processes of tumor proliferation,...
Integrative Analysis of Telomere-Related Genes Reveals Prognostic Signatures in Laryngeal Cancer [0.03%]
端粒相关基因的综合分析揭示了喉癌的预后标志物
Yesong Cheng,Yingjie Zhao,Lin He et al.
Yesong Cheng et al.
Background: Laryngeal cancer (LC) is a common malignant tumor. Telomere-related genes (T-RGs) play critical roles in cellular senescence and carcinogenesis, but their prognostic relevance in LC remains to be fully elucida...
Comprehensive Analysis Based on the Cancer-Immunity Cycle Identifies a Novel Immunosuppressive Subtype of Bladder Cancer [0.03%]
基于癌症免疫循环的综合分析识别出新型免疫抑制性膀胱癌亚型
Zexun Deng,Yifan Li,Yuyong Shen et al.
Zexun Deng et al.
Background: Immune checkpoint blockade (ICB) has reshaped the approach to treating a broad spectrum of cancers, including bladder cancer (BLCA). However, a substantial fraction of BLCA patients still exhibit resistance de...
Abdoul-Razak Oumarou Mahamane,Junior S Kamara,Moise Hubert Byiringiro et al.
Abdoul-Razak Oumarou Mahamane et al.
Flooding is a dominant constraint to rice production in lowland and floodplain ecosystems, where stress intensity, timing, and duration vary widely across agroecological zones. This review synthesizes current knowledge on flooding typologie...
A Cross-Tissue Multiomics Analysis Reveals the Protective Role of TGFBR3 in Postmenopausal Osteoporosis [0.03%]
跨组织多组学分析揭示TGFBR3在绝经后骨质疏松症中的保护作用
Yimin Liu,Chenxu Xie,Kaiwen Yang et al.
Yimin Liu et al.
Background: Postmenopausal osteoporosis (PMO) develops as a result of pathological cross-tissue interactions. However, current experimental paradigms are constrained by their single-tissue focus, hindering efforts to disc...
Integrative Single-Cell Transcriptomics and Network Pharmacology Analysis of Xiao Qing Long Tang in Pediatric Cough-Variant Asthma [0.03%]
小青龙汤治疗儿童变应性咳嗽的整合单细胞转录组和网络药理学分析
Mingming Cui,Qianqian Li,Xue Ding et al.
Mingming Cui et al.
Background: Pediatric cough-variant asthma is characterized by chronic airway inflammation and epithelial dysfunction driven by complex cellular interactions and molecular regulatory networks. Understanding the cellular h...
Integrative Mendelian Randomization and Pathomics Analysis Using Expression Quantitative Trait Loci and Genome-Wide Association Study Data Identifies Mismatch Repair Genes as Prognostic Biomarkers in Gastric Adenocarcinoma [0.03%]
利用表达定量性状位点和全基因组关联数据进行整合性的孟德尔随机化和路径组学分析，确定错配修复基因作为胃腺癌的预后生物标志物
Yingqiao Zhang,Dan Li,Yuyao Jin et al.
Yingqiao Zhang et al.
Background: Mismatch repair (MMR) genes are implicated in stomach adenocarcinoma (STAD). This study assessed their causal role in STAD, prognostic value, and developed a histopathology-based model to predict MutS homolog ...
Prognostic and Immunomodulatory Roles of BNIP3 in Osteosarcoma Revealed by Integrated Single-Cell and Bulk Transcriptomic Profiling [0.03%]
整合单细胞和批量转录组分析揭示BNIP3在骨肉瘤中的预后和免疫调节作用
Jiamiao Li,Wei Wang,Li Li et al.
Jiamiao Li et al.
Osteosarcoma is a highly aggressive bone tumor with a complex tumor microenvironment (TME) that contributes to its progression and therapeutic resistance. In this study, we integrated single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq ...