COL22A1 Activates the PI3K/AKT Signaling Pathway to Sustain the Malignancy of Glioblastoma [0.03%]
COL22A1通过激活PI3K/AKT信号通路维持胶质母细胞瘤恶性表型
Tao Zheng,Yuanzhi Huang,Dong Chu et al.
Tao Zheng et al.
Background: Glioblastoma (GBM) represents an aggressive malignancy in the central nervous system, with a poor prognosis. Despite ongoing research efforts, there is still a lack of effective treatments, leading to the need for new therapeuti...
Investigation of the Significance of Blood Signatures on Sepsis-Induced Acute Lung Injury in Sepsis Within 24 Hours [0.03%]
败血症24小时内血液谱型对指导败血症诱导的急性肺损伤的意义研究
Zaojun Fang,Yuanyuan Wang,Lingqi Xu et al.
Zaojun Fang et al.
Background: Sepsis is an infection-induced dysregulated cellular response that leads to multiorgan dysfunction. As a time-sensitive condition, sepsis requires prompt diagnosis and standardized treatment. This study investigated the impact o...
Assessment of MXD3 Expression as a Predictor of Survival in Lung Squamous Cell Carcinoma [0.03%]
MXD3表达作为预测肺鳞状细胞癌患者预后的标志物价值评估研究
Mingzhi Cao,Ning Zhang,Tangbing Chen et al.
Mingzhi Cao et al.
Backgrounds and Aims: Lung squamous cell carcinoma (LUSC) represents a significant challenge in oncology, necessitating the identification of novel prognostic markers and therapeutic targets. This study is aimed at investigating the oncogen...
Comprehensive Single-Cell RNA Sequencing Analysis of Cervical Cancer: Insights Into Tumor Microenvironment and Gene Expression Dynamics [0.03%]
全面的宫颈癌单细胞RNA测序分析：关于肿瘤微环境和基因表达动态的见解
Xiaoting Shen,Huier Sun,Shanshan Zhang
Xiaoting Shen
Background: Cervical cancer is a complex disease with considerable cellular heterogeneity, which hampers our understanding of its progression and the development of effective treatments. Single-cell RNA sequencing (scRNA-seq)-a technology t...
Analysis of Genotypes and Phenotypes in Chinese Patients With Tuberous Sclerosis Complex Harboring Novel Variants of TSC1 and TSC2 Genes [0.03%]
中国结节性硬化症患者的基因和表型分析&TSC1和TSC2新变异基因患者
Jian Chen,Hairui Sun,Ling Han et al.
Jian Chen et al.
Background: This study aimed to assess the pathogenicity of newly identified tuberous sclerosis Complex 1 (TSC1) and TSC2 variants, contributing definitive evidence for the diagnosis of TSC. Methods: A total of 103 TSC patients underwent TS...
Decoding the Tumor Microenvironment of Myoepithelial Cells in Triple-Negative Breast Cancer Through Single-Cell and Transcriptomic Sequencing and Establishing a Prognostic Model Based on Key Myoepithelial Cell Genes [0.03%]
通过单细胞和转录组测序解码三阴性乳腺癌肌上皮细胞肿瘤微环境并基于关键肌上皮细胞基因建立预后模型
Xiaocheng Yu,Ye Tian,Rui Zhang et al.
Xiaocheng Yu et al.
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype with high malignancy, rapid progression, and a poor 5-year survival rate of ~77%. Due to the lack of targeted therapies, treatment options are limited, highlighting t...
An Oxford Nanopore Technologies-Based Sequencing Assay for Molecular Diagnosis of Phenylketonuria and Variant Frequencies in a Turkish Cohort [0.03%]
基于牛津纳米孔技术的 sequencing 试验在苯酮尿症分子诊断及突变频率检测中的应用——针对土耳其人群的一项研究
Gülten Tuncel,Mehmet Cihan Balcı,Gökçe Akan et al.
Gülten Tuncel et al.
Background: Phenylketonuria (PKU) is an autosomal recessive metabolic disorder caused by mutations in the PAH gene, resulting in deficient phenylalanine hydroxylase (PAH) enzyme activity and neurotoxic phenylalanine accumulation. Untreated ...
Multiomics Approach Distinguishes SPTBN4 as a Key Molecule in Diagnosis, Prognosis, and Immune Suppression of Testicular Seminomas [0.03%]
多组学方法区分SPTBN4在睾丸精原细胞瘤诊断、预后和免疫抑制中的重要作用
Jianfeng Xiang,Yanjie Xiang,Qintao Ge et al.
Jianfeng Xiang et al.
Background: Testicular seminomas, a common germ cell tumor, poses clinical challenges due to its molecular heterogeneity and limited biomarkers for precise diagnosis and prognosis. Leveraging multiomics approaches enables the comprehensive ...
The Relationship Between Preoperative Neutrophil-Lymphocyte Ratio and Postoperative Length of Stay in Carotid Body Tumor Resection [0.03%]
术前中性粒细胞淋巴细胞比值与副神经节瘤切除术后住院时间的关系分析
Biao Wu,Jiang Zhu,Liang Chen et al.
Biao Wu et al.
Carotid body tumor (CBT) resection is a complex surgical procedure often resulting in extended postoperative length of stay (PLOS) due to potential nerve injuries, arterial damage, and wound complications. The neutrophil-to-lymphocyte ratio...
KCNJ2 Facilitates Clear Cell Renal Cell Carcinoma Progression and Glucose Metabolism [0.03%]
KCNJ2促进透明细胞肾细胞癌的进展和葡萄糖代谢
Qiyue Zhao,Zhengshu Wei,Guanglin Yang et al.
Qiyue Zhao et al.
Background: Clear cell renal cell carcinoma (ccRCC) is marked by aggressive characteristics and a poor prognosis. The involvement of KCNJ2, an inward rectifying potassium channel, in the progression of ccRCC, along with its potential roles ...