Alport Syndrome-Associated Pathogenic COL4A4 Variant in Sisters With Chronic Kidney Disease: Clinical Findings and Integrative Network Analysis [0.03%]
COL4A4致病突变在两名患慢性肾脏疾病的姐妹中的临床研究及整合网络分析
Bakhtawar Farooq,Zahid Habib Qureshi,Muhammad Tahir Khan et al.
Bakhtawar Farooq et al.
Background: Pathogenic variants in the COL4A4 gene lead to Alport syndrome, a hereditary kidney disorder characterized by deficiencies in the glomerular basement membrane (GBM), progressive renal failure, and associated v...
S100A9 Integrates Autophagic Deficiency With Immunopathology and Latanoprost Responsiveness in Primary Open-Angle Glaucoma [0.03%]
S100A9介导的自噬缺陷在原发性开角型青光眼中的免疫病理作用及其对拉坦前列素的反应性降低
Lili Hu,Shaoxin Pan,Gong Chen et al.
Lili Hu et al.
Primary open-angle glaucoma (POAG) is a progressive optic neuropathy that leads to irreversible vision loss, primarily due to dysfunction of the trabecular meshwork (TM). Although impaired autophagy has been implicated in POAG pathogenesis,...
BDKRB1 Links Copy Number-Defined Genomic Instability to Inflammatory and Immunosuppressive Tumor Ecosystems in Ovarian Cancer: An Integrative Multiomics Analysis [0.03%]
卵巢癌中BDKRB1将拷贝数定义的基因组不稳定性与炎性和免疫抑制性肿瘤生态系统联系起来：整合多组学分析
Dali Pu,Huagui Chen,Xia Wang et al.
Dali Pu et al.
Background: Ovarian cancer is characterized by high mortality, extensive genomic instability driven by copy number alterations, and a highly immunosuppressive tumor microenvironment. Increasing evidence suggests that chro...
CEACAM1 Is Associated With an Immune-Activated Tumor Microenvironment and Therapeutic Stratification in Sarcoma [0.03%]
CEACAM1与免疫激活的肉瘤肿瘤微环境及治疗分层相关
Ziqi Cao,Minjue Shan,Yadong Guo et al.
Ziqi Cao et al.
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a multifunctional immunomodulatory protein involved in both immune activation and immune suppression across diverse cancer types. However, its biological significance an...
Gut Microbiota and Primary Liver Cancer: Mendelian Randomization and Network Pharmacology Used to Predict Potential Therapeutic Intervention With Traditional Chinese Medicine [0.03%]
肠道菌群与原发性肝癌：孟德尔随机化和网络药理学预测潜在的中医治疗干预措施
Qingliang Chen,Lin Jin,Suping Ding et al.
Qingliang Chen et al.
Objective: The objective of this study is to employ Mendelian randomization (MR) to screen for gut microbiota (GM) exhibiting causal genetic effects on primary liver cancer (PLC) development and to predict promising tradi...
m6A Methyltransferase METTL3 Regulates Inflammatory and Immune Microenvironments in Renal Cell Carcinoma via Modulation of the PI3K/AKT Pathway [0.03%]
通过调节PI3K / AKT信号传导途径在肾细胞癌中调控炎症和免疫微环境的m6A甲基转移酶METTL3
Tao Cheng,Weiqiang Xu,Zeyu Zha et al.
Tao Cheng et al.
Objective: The involvement of methyltransferase-like 3 (METTL3, an m6A methyltransferase) and the PI3K/AKT pathway in tumor progression and immune regulation remains poorly understood. This study investigates whether METT...
Causal Effects of Atrial Fibrillation and Warfarin Use on Osteoporosis Risk: A Two-Sample Mendelian Randomization Analysis [0.03%]
房颤和华法林使用对骨质疏松症风险因果效应的两样本孟德尔随机化分析
Xiao Hu,Jiaqin Cai,Xiaoxia Wei et al.
Xiao Hu et al.
Objective: A number of observational studies have previously reported an association between atrial fibrillation (AF), long-term warfarin therapy, and an increased risk of osteoporosis (OP). The proposed mechanisms behind...
Single-Cell Transcriptomics Reveals the Potential Role of GZMK+ CD8+ T Cells in Cell Senescence of Triple-Negative Breast Cancer [0.03%]
单细胞转录组揭示GZMK+CD8+T细胞在三阴性乳腺癌细胞衰老中的潜在作用
Dan Zhou,Tianhui Hu,Beibei Xu et al.
Dan Zhou et al.
Senescence is a critical risk factor for the development of triple-negative breast cancer (TNBC), yet its specific impact on the disease remains inadequately understood. This study aims to elucidate the role of pivotal genes in mediating th...
Single-Cell Transcriptomic Atlas Reveals Metabolic Reprogramming and Transdifferentiation Trajectories in Tubular Epithelial Cells During Chronic Kidney Disease Progression [0.03%]
单细胞转录组揭示了慢性肾脏病进展过程中上皮细胞的代谢重塑和转分化轨迹
Xinhui Mao,Minggang Wei,Yilin Li et al.
Xinhui Mao et al.
Background: In chronic kidney disease (CKD), there is evidence of loss of function and fibrosis in the progression of tubular epithelial cells; however, the cellular heterogeneity and underlying molecular mechanisms are n...
Aflatoxin B1 Impairs TACE Efficacy Through Downregulated Carbonic Anhydrase 2: A Bioinformatics Analysis [0.03%]
黄曲霉毒素B1通过下调碳酸酐酶2影响TACE疗效的 bioinformatics分析
Pengsheng Zhang,Yuyun Tong,Xiran Feng et al.
Pengsheng Zhang et al.
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide, and transcatheter arterial chemoembolization (TACE) remains the core locoregional therapeutic modality for patients with intermediate to adva...