Identification of Biomarkers Based on Starvation Response-Related Genes for Assessing the Immune Profile and Prognosis in Lung Adenocarcinoma [0.03%]
基于饥饿反应相关基因鉴定生物标志物以评估肺癌免疫特征及预后指标
Xixian Lou,Hui Xia,Zongxiao Shangguan et al.
Xixian Lou et al.
Background: Lung adenocarcinoma (LUAD) exhibits a high recurrence rate and an unfavorable prognosis. The role of the starvation-induced tumor microenvironment (TME), which is closely linked to metabolism, remains poorly understood in LUAD. ...
Effects of Different Components of Buyang Huanwu Tang on the PPAR γ/LXR α/ABCA1 Pathway in Hypercholesterolemia Mouse Model [0.03%]
不同补阳还古汤成分对高胆固醇血症模型鼠PPARγ/LXRα/ABCA1通路的影响研究
Shuaihu Yang,Yukun Zhang,Xinxin Liu et al.
Shuaihu Yang et al.
The aim of this study is to compare the effects of different components of Buyang Huanwu Tang (BYHWT) on the peroxisome proliferator-activated receptor γ (PPARγ)/liver X receptor α (LXRα)/ATP-binding cassette transporter A1 (ABCA1) path...
Cooling Blood and Detoxicating Formula Treats Psoriasis Through RHCG-Related Mechanisms [0.03%]
凉血解毒方通过RHCG相关机制治疗银屑病
Qian Zhang,Juan Huang,Cheng-Cheng Feng et al.
Qian Zhang et al.
This study explores the therapeutic potential of the cooling blood and detoxicating formula (CBDF) in the treatment of psoriasis, emphasizing its anti-inflammatory properties and its interaction with RHCG-related mechanisms. Psoriasis, a co...
Exploring the Genetic Basis of Ketosis: Preliminary GWAS Findings on Beta-Hydroxybutyrate Levels in Holstein Cattle [0.03%]
酮血症的遗传基础探索——奶牛β-羟基丁酸水平的初步基因组-wide关联分析研究
Veysel Bay
Veysel Bay
Ketosis is a metabolic condition characterized by a shift in energy metabolism, occurring when glucose availability is depleted and fat becomes the alternative primary energy source, resulting in the accumulation of ketone bodies. In dairy ...
FENDRR Affects COAD Biological Behavior by Inhibiting the DUSP4/CREB/PRKACB Pathway [0.03%]
FENDRR通过抑制DUSP4/CREB/PRKACB通路影响结肠腺癌生物学行为
Hao Zhang,Li Hong,Zirui Zhuang et al.
Hao Zhang et al.
Background: Colorectal cancer (CRC) is acknowledged as the third leading cause of cancer-related mortality, attributed to its high incidence and fatality rates. Long noncoding RNAs (lncRNAs) have emerged as novel biomarkers for the treatmen...
Investigating Overlapping Genetic Factors and Novel Causal Genes in Autoimmune Diseases: A Transcriptome-Wide Association and Multiomics Study [0.03%]
自身免疫病中共有遗传因素及新致病基因的调查研究：转录组关联分析和多组学研究
Leihua Fu,Jieni Yu,Xin Wang et al.
Leihua Fu et al.
Background: Autoimmune diseases exhibit familial clustering and co-occurrence, suggesting the presence of shared genetic risk factors. However, the overlapping genetic factors across these diseases have yet to be fully elucidated. This stud...
Association of Cannabinoid CB2 Receptor Q63R Variant With Rheumatoid Arthritis in an Iranian Cohort [0.03%]
伊朗人群中 cannabinoid cb2 体 q63r 多态性与类风湿关节炎的关联研究
Ali Nateghi,Samin Zamani,Alireza Tahamtan
Ali Nateghi
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease primarily affecting the joints. The endocannabinoid system plays a crucial role in maintaining immune balance by regulating immune functions. Variations in the CB2 recept...
A CD8+ T Cell Infiltration-Driven Prognostic Signature for Gastric Cancer: Bridging Tumor Immunity and Clinical Outcomes [0.03%]
基于CD8+t细胞浸润的胃癌预后预测标志及其临床意义研究
Yiting Qian,Bo Sun,Linying Lai et al.
Yiting Qian et al.
Background: CD8+ T cells play pivotal roles in antitumor immunity, where infiltration levels often correlate with favorable prognosis. However, the functional heterogeneity of CD8+ T cell subsets within the gastric cancer (GC) tumor microen...
Mechanisms Underlying the Therapeutic Effects of Brucea javanica in Cervical Cancer Treatment Based on Network Pharmacology and Molecular Docking [0.03%]
基于网络药理学和分子对接的Brucea javanica治疗宫颈癌机制研究
Wen Jin,Bin Li,Lu Zhang et al.
Wen Jin et al.
Aims: The aim of this study was to systematically analyze the role of Brucea javanica in the treatment of cervical cancer (CC) and its underlying mechanisms by means of network pharmacology and molecular docking. Background: Brucea javanica...
Promoter Region and Regulatory Elements of IGF and VIP Genes Associated With Reproductive Traits in Chicken [0.03%]
与家禽繁殖性状相关的IGF和VIP基因的启动子区域和调控元件
Bosenu Abera,Hunduma Dinka,Hailu Dadi et al.
Bosenu Abera et al.
This study investigates the promoter region and regulatory elements of chicken insulin-like growth factor (IGF) and vasoactive intestinal polypeptide (VIP) genes associated with reproductive traits. Several in silico tools, such as Neural N...