Network Pharmacology and Single-Cell Transcriptomic Investigation of Molecular Mechanisms Underlying Erigeron breviscapus Treatment in Acute Myocardial Infarction [0.03%]
网络药理学和单细胞转录组研究短柄草治疗急性心肌梗死的分子机制
Lili Yan,Jun Cao,Qinglong Xie et al.
Lili Yan et al.
Background: Acute myocardial infarction (AMI) represents a life-threatening cardiovascular emergency characterized by myocardial necrosis resulting from prolonged ischemia. Erigeron breviscapus (Vant.) Hand.-Mazz. (EB), a...
An Epithelial-Mesenchymal Transition-Driven Transcriptional Index Stratifies Immunosuppression and Therapeutic Resistance in Bone Malignancies [0.03%]
基底细胞癌中上皮间质转化驱动的转录指数划分免疫抑制和治疗抵抗
Lihe Pang,Ye Hua,Zhaofei Chen et al.
Lihe Pang et al.
The aggressive clinical course and limited treatment avenues for key bone malignancies, specifically osteosarcoma, Ewing's sarcoma, and giant cell tumor of bone, are heavily dictated by their intricate tumor microenvironment (TME). To decod...
Integrative Transcriptomic and Single-Cell Analyses Identify ATP1A1 as a Prognostic and Immune-Associated Factor in Esophageal Cancer [0.03%]
整合转录组和单细胞分析鉴定出ATP1A1是食管癌预后和免疫相关因素
Huishen Yan,Liang He
Huishen Yan
Background: Esophageal cancer is a highly aggressive malignancy with poor prognosis and limited molecular markers for effective risk stratification and therapeutic guidance. Mitochondrial stress-related pathways are incre...
Single Cell and Machine Learning-Based Analysis of Lysosome Mediated Cell Death Reveals Novel Prognostic Biomarkers and Therapeutic Targets in Cervical Cancer [0.03%]
基于单细胞和机器学习的溶酶体介导的宫颈癌细胞死亡分析发现新的预后生物标志物和治疗靶点
Yurong Cheng,Xuan Li,Dong Yan
Yurong Cheng
Background: Cervical cancer is among the most prevalent gynecological malignancies globally, and its inherent molecular heterogeneity remains a persistent obstacle to uniform treatment efficacy and patient survival. Lysos...
USP44 Stabilizes MAOB via Deubiquitination to Inhibit Cisplatin Resistance in Lung Adenocarcinoma [0.03%]
USP44通过去泛素化稳定MAOB以抑制肺腺癌顺铂耐药性
Zhi Liang,Hui Zhang,Jinhua Jiang et al.
Zhi Liang et al.
Background: Cisplatin (DDP), as a commonly used chemotherapeutic agent for the clinical treatment of lung adenocarcinoma (LUAD), serves a key function in suppressing tumor progression; however, the development of tumor ce...
PSIP1 Orchestrates Immune Escape in Osteosarcoma: Insights From Single-Cell Analysis and Implications for Immunotherapy Resistance [0.03%]
PSIP1在骨肉瘤中 orchestrate免疫逃逸：单细胞分析的见解及其对免疫治疗耐药性的意义
Simin Liu,Hong Yan,Wei Ku et al.
Simin Liu et al.
Background: Osteosarcoma (OS) is characterized by a highly heterogeneous tumor microenvironment (TME) that frequently limits the efficacy of immunotherapy. Identifying molecular drivers of immune escape (IE) is essential ...
Identification of Key Genes in Acute Liver Failure via Analysis of Programmed Cell Death Patterns [0.03%]
通过分析程序性细胞死亡模式鉴定急性肝功能衰竭的关键基因
Guangli Liu,Huili Wu,Wenxiang Shi et al.
Guangli Liu et al.
Objective: Acute liver failure (ALF) is a severe condition with high mortality, where programmed cell death (PCD) plays a critical yet not fully understood role. This study aimed to identify key PCD-related genes and expl...
Single-Cell RNA Sequencing Reveals Dynamic Expression Patterns of MAIT Cells and Macrophage Subpopulations in Myocardial Injury Model [0.03%]
单细胞RNA测序揭示心肌损伤模型中MAIT细胞和巨噬细胞亚群的动态表达模式
Haofei Kang,Junjie Wang,Renjie Ruan et al.
Haofei Kang et al.
Background: Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes involved in immune surveillance and tissue homeostasis. Yet, their transcriptional dynamics and functional crosstalk with macrophages a...
Lipid Metabolism-Related Genes Define Prognosis and Therapeutic Targets in Thyroid Cancer [0.03%]
与脂质代谢相关的基因可定义甲状腺癌的预后和治疗靶点
Tianze Wang,Boyuan Nan,Qila Sa et al.
Tianze Wang et al.
Background: Altered lipid metabolism is increasingly recognized as a driver of tumor progression, yet its specific role in thyroid cancer remains unclear. ...
SLC7A7 Downregulation in Monocytes Drives Immunosuppression and Osteosarcoma Progression [0.03%]
单核细胞中SLC7A7下调驱动免疫抑制和骨肉瘤进展
Bingjie Jiang,Haoran Zhu,Zhenxing Zhang
Bingjie Jiang
Background: Metabolic reprogramming and the formation of an immunosuppressive tumor microenvironment(TME) are hallmarks of osteosarcoma (OS). However, the metabolic characteristics of OS and its associated immune microenv...