Effects of Gender Differences in MTHFR 677C > T and Homocysteine Level on the Occurrence of Adverse Pregnancy Outcomes [0.03%]
同型半胱氨酸及MTHFR基因多态性差异对不良妊娠结局的影响研究进展
Qian-Nan Guo,Shi-Xiu Liao,Hong-Yan Liu et al.
Qian-Nan Guo et al.
Background: The MTHFR 677C > T polymorphism in women has been associated with an increased risk of deep venous thrombosis and adverse pregnancy outcomes (APOs). However, research concerning its effects in men remains limited. Methods: This ...
Exploration of the Roles and Mechanisms Between Tumor-Infiltrating Lymphocytes and Hepatocellular Carcinoma Based on Single-Cell Transcriptomics [0.03%]
基于单细胞转录组学探讨肿瘤浸润淋巴细胞与肝癌的作用及机制研究
Taiyu Shi,Donghao Cheng,Xinyan Du et al.
Taiyu Shi et al.
Hepatocellular carcinoma (HCC) remains a major global health challenge, with limited effective treatment options, particularly in advanced-stage patients. The tumor immune microenvironment (TIME) plays a crucial role in HCC progression and ...
Deubiquitinase Genes as Prognostic Biomarkers in Osteosarcoma: Insights From Single-Cell Sequencing and Machine Learning-Based Prognostic Modeling [0.03%]
去泛素化酶基因作为骨肉瘤预后生物标志物：单细胞测序和基于机器学习的预后建模的新见解
Meng Zhang,Chunxin Cheng,Gang Liu
Meng Zhang
Background: Osteosarcoma (OS) is a highly aggressive bone tumor characterized by poor prognosis and frequent metastasis. Despite advances in treatment, the survival rate remains low. This study investigates the role of deubiquitinase (DUB) ...
Identification of lncRNA HCCAT5 as a Novel Biomarker for Gastric Cancer [0.03%]
胃癌新型生物标志物长链非编码RNAHCCAT5的鉴定
Nazila Saedi Alvaroliya,Seyedeh Hayla Jahanshahi,Nazli Khajehnasiri et al.
Nazila Saedi Alvaroliya et al.
Background: Gastric cancer (GC) is a widespread type of cancer on a global scale, standing as the fifth most frequently occurring malignant disease. Dysregulation of long noncoding RNAs (lncRNAs) due to genomic mutations in noncoding DNA se...
Shi Li,Lijun Shi,Xiaofeng Tao et al.
Shi Li et al.
Kidney renal clear cell carcinoma (KIRC), the most common type of renal cell carcinoma, is an immunobiologically and metabolically distinct tumor. Its clinical management is closely related to the tumor microenvironment (TME). Identifying i...
Atf3 Promotes Spinal Cord Injury by Exacerbating Neuronal Oxidative Stress and Inflammation via the NF- κ B Signaling Pathway [0.03%]
ATF3通过NF-κB信号通路加剧神经氧化应激和炎症促进脊髓损伤
Haijian Yan,Pingjiang An,Jingjing He et al.
Haijian Yan et al.
Background: Spinal cord injury (SCI) is a central nervous system disorder characterized by oxidative stress and inflammatory responses. Activating transcription factor 3 (Atf3) is an early-response stress-regulating gene whose abnormal upre...
A Study to Evaluate the Potential Role and Clinical Application Value of Long Noncoding RNA CASC Family Members in Colorectal Cancer Based on Transcriptomic Data [0.03%]
基于转录组数据评估长链非编码RNA CASC家族成员在结直肠癌中潜在作用和临床应用价值的研究
Chao Liang,Jun Wang,Xinyu Liu
Chao Liang
Background: Long noncoding RNA (lncRNA) CASC, crucial in colorectal cancer (CRC) progression, remains largely unexplored despite its potential. Methods: The CRC data comes from The Cancer Genome Atlas (TCGA) database. The limma package was ...
Whole Exome Sequencing Identified a Stop-Gained Mutation in DYSF Gene Associated With Dysferlinopathy in an Iranian Family [0.03%]
伊朗一家源性肌营养不良的基因突变及其功能研究
Saba Baghshomali,Asiyeh Jebelli,Mina Kazemzadeh et al.
Saba Baghshomali et al.
Introduction: Muscular dystrophy (MD) refers to a group of hereditary disorders characterized by progressive muscle degeneration, often caused by a deficiency or insufficient levels of glycoproteins in muscle cell membranes. Mutations in va...
Molecular Basis of Aggressiveness in Pituitary Adenomas and Its Association With the Immune Microenvironment [0.03%]
垂体腺瘤侵袭性的分子基础及其与免疫微环境的关系
Xiaoyan Chen,Jingnan Wang,Qianqian Guo
Xiaoyan Chen
Background: Pituitary adenomas (PAs) are common intracranial tumors, and their aggressive phenotype exhibits a poor prognosis. We aimed to explore the aggressive feature of PAs and discover novel diagnostic markers. Method: The datasets of ...
Distribution of Methylene Tetrahydrofolate Reductase Gene Polymorphisms in Women of Childbearing Age in Tai'an [0.03%]
泰安市育龄妇女亚甲基四氢叶酸还原酶基因多态分布调查研究
Bo Zhou,Chengzhen Gao,Lirong Chen et al.
Bo Zhou et al.
Objective: The objective was to explore the distribution characteristics of methylenetetrahydrofolate reductase MTHFR 677C > T and 1298A > C gene polymorphisms among women of childbearing age in the Tai'an area. Method: A total of 243 women...