Integrative Genomic Analysis Reveals Pseudouridine Modification-Related Gene Signatures Associated With Prognosis and Therapeutic Response Patterns in Hepatocellular Carcinoma [0.03%]
整合基因组分析揭示假尿嘧啶修饰相关基因特征与肝细胞癌预后及治疗反应模式之间的关联性
Zeying Gan,Tingyuan Fan,Wenjuan Wang et al.
Zeying Gan et al.
Background: Hepatocellular carcinoma (HCC) is a genomically heterogeneous malignancy with substantial variability in prognosis and therapeutic response. Pseudouridine (Ψ) modification is an evolutionarily conserved RNA m...
Multilevel Genetic and Functional Assessment of an ARR3 Frameshift Variant in Early-Onset High Myopia [0.03%]
早发性高度近视的多级基因和功能评估ARR3移码变异
Yadi Li,Fengwu Teng,Qin Zhu et al.
Yadi Li et al.
Background: Early-onset high myopia (eoHM) is a highly heritable ocular disorder, with pathogenic variants in the X-linked ARR3 gene (which encodes cone arrestin) being associated with a female-limited form of eoHM. Howev...
Deciphering the Heterogeneous Microenvironment of Head and Neck Squamous Cell Carcinoma Through an Integrated Immune Inflammation Framework [0.03%]
通过整合免疫炎症模型解读头颈鳞癌异质性微环境
Jie Li,Shuxian Sun,Ziyu Ji et al.
Jie Li et al.
Background: Head and neck squamous cell carcinoma (HNSC) exhibits substantial prognostic and microenvironmental heterogeneity. However, the integrated prognostic relevance of synergistic immune and inflammatory signatures...
Exosome-Related Gene Signature Predicts Prognosis and Immunotherapy in Gastric Cancer [0.03%]
外泌体相关基因谱预测胃癌预后和免疫治疗效果
Qunru Jiao,Rui Zhang,Yingyun Guo et al.
Qunru Jiao et al.
Exosomes play a crucial role in tumor progression. However, reliable exosome-related biomarkers for predicting prognosis in gastric cancer (GC) remain scarce. This study is aimed at developing an exosome-related gene risk signature (ERGRS) ...
Genome Wide Identification and Characterization of BrE2F Family Gene of Brassica rapa [0.03%]
白菜型油菜BrE2F基因家族的全基因组鉴定及特征分析
Naima Sultana,Md Jahid Hasan Jone,Anjan Chandra Sharma et al.
Naima Sultana et al.
The E2F family gene is one of the most important G1-S checkpoint regulatory transcription factors to monitor and regulate the accurate DNA replication and progression of the cell cycle in eukaryotes. Expression of this gene in multiple envi...
Combining Machine Learning, Single-Cell Sequencing Data, and Mendelian Randomization Studies to Explore the Correlation Between Ischemic Stroke and Inflammatory Pathway Genes [0.03%]
结合机器学习、单细胞测序数据和孟德尔随机化研究探索缺血性卒中与炎症通路基因的相关性
Si Wang,Yan Xu,Meilei Wang et al.
Si Wang et al.
Background: Ischemic stroke (IS) is a severe neurological disorder, with inflammation playing a crucial role in its development. This study is aimed at investigating the gene expression profiles related to inflammation in...
Investigation of Pharmacogenomic Variants in the CYP (P450) Family in Native American Populations of the Brazilian Amazon [0.03%]
巴西亚马逊土著人群中的细胞色素P450家族药理基因组变异研究
Lilian Marques de Freitas,Juliana Carla Rodrigues Marcellino,Francisco Cezar Aquino de Moraes et al.
Lilian Marques de Freitas et al.
The cytochrome P450 (CYP) enzyme superfamily is essential for xenobiotic metabolism, detoxification pathways, and the regulation of cellular homeostasis. Genetic variability in CYP genes, together with environmental factors, contributes sub...
Single Cell Transcriptomic Atlas Reveals Cellular Heterogeneity and Molecular Mechanisms in Pediatric Airway Hyperresponsiveness Epithelium [0.03%]
单细胞转录组揭示了儿童气道高反应上皮的异质性和分子机制
Weiming Yang,Shunfeng Mao,Liuyang Zhou
Weiming Yang
Background: Airway hyperresponsiveness (AHR) is a clinically important feature of chronic pediatric inflammatory airway disease, but its cellular architecture remains incompletely resolved. Because bulk transcriptomic app...
Gut Microbiome-Metabolite Interactions Contribute to Esophageal Cancer Risk: Evidence From Mendelian Randomization and Multiomics Integration [0.03%]
基于孟德尔随机化和组学整合的证据提示肠道微生物群-代谢物互作参与食管癌发病风险的作用
He Yang,Yi Liu,Tianyu Zhu et al.
He Yang et al.
Background: Growing evidence implicates gut microbiota (GM) in the pathogenesis of esophageal cancer (EC). However, the causal nature of this association-particularly the potential mediating role of circulating metabolite...
Integrative Analysis of Genetic Risk Factors for Acute Myeloid Leukemia Using Mendelian Randomization and Single-Cell RNA Sequencing Validation [0.03%]
基于孟德尔随机化和单细胞RNA测序验证的急性髓系白血病遗传风险因素整合分析
Tian Xia,Ruiting Wen,Guocai Wu et al.
Tian Xia et al.
Background: Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy with complex genetic underpinnings. Understanding the causal relationships between genetic factors and AML risk is crucial for developing ...