A Computational Investigation of Small Peptide of Methyl Jasmonate and Human Complement Factor in Ageing [0.03%]
甲基茉莉酸和人补体因子的小肽在衰老中的计算研究
Oluwafemi G Oluwole,Ngalla Jillani,Afolake Arowolo et al.
Oluwafemi G Oluwole et al.
Background: Ageing contributes to the onset of various diseases. It is accompanied by malfunctioning and deterioration of the body systems. Identifying the biomarkers for the prediction, diagnosis, management, or prognosi...
Cathepsin Levels and Atrial Fibrillation Risk: Insights From Bidirectional and Multivariable Mendelian Randomization Analyses [0.03%]
猫hepsin水平与房颤风险的关系：双向和多变量孟德尔随机化分析的见解
Fang Ye,Ruya Zhou,Haiying Lin et al.
Fang Ye et al.
Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia, contributing to substantial morbidity, mortality, and healthcare burden. While genome-wide association studies (GWAS) have identified numerous ge...
Mapping the Research Landscape of Exercise and Breast Cancer: A Bibliometric Analysis From 2020 to 2024 [0.03%]
2020-2024年运动与乳腺癌研究领域文献计量分析
Jian Li,LiYing Qiang,MingYue Jiao et al.
Jian Li et al.
Even though there is strong evidence that exercise improves breast cancer patients' quality of life, treatment tolerance, and survival, disparate research initiatives and uneven clinical acceptance underscore the need for a thorough synthes...
Identification and Validation of the Key Genes of Diabetic Vasculopathy: Evidence Based on Bioinformatics Analysis and Animal Study [0.03%]
基于生物信息学分析和动物实验的糖尿病血管病变关键基因鉴定及验证
Feng Li,Chi Geng,Xing Xu et al.
Feng Li et al.
Backgrounds: The mechanisms contributing to diabetic vasculopathy have not been fully understand. Methods: First, we identified differe...
Identification of Key Periodontitis Genes and Their Mechanisms of Action Using Comprehensive Multiple Microarray Analysis and Mendelian Randomization Methods [0.03%]
利用全面的多重基因芯片分析和孟德尔随机化方法鉴定关键牙周炎基因及其作用机制
Kezhen Xiang,Conghua Li,Na Hu
Kezhen Xiang
Background: Periodontitis, a chronic inflammatory disease, damages the soft tissues and bones around the teeth. Affecting adults, mild periodontitis is common, while severe cases impact up to 20% of individuals, with a pr...
Identification of Core Senescence-Related Genes and Characterization of Comprehensive Immune Landscape in Intervertebral Disc Degeneration [0.03%]
髓核细胞衰老相关关键基因鉴定及椎间盘退变免疫图谱分析
Qiang Xu,Zeshuang Lian,Aoting Wang et al.
Qiang Xu et al.
Background: Intervertebral disc degeneration (IVDD) is a musculoskeletal degenerative disease closely associated with age and immunoreaction. However, the mechanism of senescence and immune infiltration landscape in IVDD ...
Identifying the Key Mitochondria-Related Genes in COPD by Integrating Machine Learning and Bioinformatics Analyses [0.03%]
通过集成机器学习和生物信息学分析识别COPD中的关键线粒体相关基因
Jiajia Qu,Mengyu Zhang,Yajie Hu et al.
Jiajia Qu et al.
Background: Chronic obstructive pulmonary disease (COPD), a prevalent chronic respiratory disorder with high morbidity and mortality, is closely associated with mitochondrial dysfunction and immune dysregulation; however,...
Exploration of the Mechanism of Tongmai Xianxiang in Treating Postherpetic Neuralgia Based on Gas Chromatography-Mass Spectrometry Analysis and Network Pharmacology [0.03%]
基于气相色谱-质谱分析和网络药理学的通脉显象治疗后遗神经痛机制探讨
Linglong Qu,Hui Wang,Yufeng Huang et al.
Linglong Qu et al.
Objective: The aim of this study is to explore the potential target of Tongmai Xianxiang in the prevention and treatment of postherpetic neuralgia (PHN) by gas chromatography-mass spectrometry (GC-MS) and network pharmaco...
Single-Cell Sequencing Redefines Immune Heterogeneity and Communication Networks in ARDS: Toward Precision Therapeutics [0.03%]
单细胞测序重新定义了ARDS中的免疫异质性和通讯网络：迈向精准治疗
Han-Bing Chen,An-Min Xu,Hai-Bo Qiu et al.
Han-Bing Chen et al.
Acute respiratory distress syndrome (ARDS) is a critical condition characterized by diffuse alveolar damage and intense inflammatory responses. During the COVID-19 pandemic, its incidence and mortality have remained persistently high. Conve...
Growth Hormone Alleviates Atherosclerosis Through Regulating the Activity of PI3K/AKT Pathway: Insights From Single-Cell Sequence and Mechanism Exploration [0.03%]
生长激素通过调节PI3K/AKT信号通路活性缓解动脉粥样硬化：单细胞测序及机制探索的全新见解
Jin Cai,Shuang Shi,Yuhang Wang et al.
Jin Cai et al.
Purpose: This research sought to investigate the impact and underlying mechanisms of growth hormone (GH) on atherosclerosis (AS) based on the analysis of single-cell RNA sequencing (scRNA-seq) data. ...