Antihypertensive Drugs and Dental Caries Risk: A Drug-Target Mendelian Randomization Analysis [0.03%]
降压药和龋齿风险的药物-靶点孟德尔随机化分析
Wenbin Shi,Shuhua Liu,Xiuxia Wu et al.
Wenbin Shi et al.
Introduction and objectives: To address the clinical uncertainty surrounding the effect of antihypertensive drugs on dental caries, this study was aimed at investigating the causal relationships between antihypertensive m...
Compound Heterozygous Null Variants in ITGB4 Gene Causing Severe Phenotype of Junctional Epidermolysis Bullosa With Pyloric Atresia in Thai Newborn: Genotype-Phenotype Correlation From a Case Report and Review of the Literature [0.03%]
ITGB4基因复合杂合无义突变导致泰国新生儿严重型页状棘层松解症伴幽门闭锁的基因分型表型相关性：病例报告及文献综述
Jeerawan Klangjorhor,Mallika Pomrop,Patcharawadee Thongkumkoon et al.
Jeerawan Klangjorhor et al.
Epidermolysis bullosa (EB) is a genetically heterogeneous skin fragility disorder. Some subtypes also involve other organs, including the pulmonary, gastrointestinal, and renal systems. One severe form, junctional epidermolysis bullosa (JEB...
NRG-1 Promotes Axon Regeneration of Dorsal Root Ganglion Neurons in Diabetic Rats via ITGB1/FAK/AKT Pathway [0.03%]
NRG-1通过ITGB1/FAK/AKT通路促进糖尿病大鼠背根节神经元轴突再生
Peng Zhan,Hewei Xiong,Hongmei Zheng
Peng Zhan
Objectives: The purpose of this study was to investigate the role of the ITGB1/FAK/AKT pathway in NRG-1 in mediating the axonal growth of dorsal root ganglion neurons in Type I diabetic rats and to explore the mechanism of neuronal axonal r...
An Integrative Analysis Identified Six Genes That Regulate the Development of Atherosclerosis Through Autophagy [0.03%]
整合分析鉴定出六种通过自噬调节动脉粥样硬化的基因
Ao Yin,Xingyu Fu,Xinxin Liu et al.
Ao Yin et al.
Background: Autophagy exerts a vital role in the development of atherosclerotic lesions. Mounting evidence suggests a significant link between autophagy and atherosclerosis. Methods: Two atherosclerotic plaque datasets were integrated from ...
SPP1+ Macrophage-Associated Prognostic Signature in Hepatocellular Carcinoma via Integrated Single-Cell and Bulk Transcriptomic Analysis [0.03%]
基于整合单细胞和批量转录组分析的肝细胞癌SPP1+巨噬细胞相关预后标志物
Suyang Yue,Qin Ding,Shanzhong Tan et al.
Suyang Yue et al.
Background: Hepatocellular carcinoma (HCC) is a major cause of cancer mortality, with limited treatment options due to its high heterogeneity. SPP1+ tumor-associated macrophages are emerging as key regulators of the tumor immune microenviro...
WUSCHEL-Related Homeobox (WOX) Gene Family in Quinoa (Chenopodium quinoa): Genome-Wide Identification and In Silico Characterization [0.03%]
藜麦(WOX基因家族的全基因组鉴定及生物信息学特征分析
Bahlanes Bakhtari,Elnaz Zamani
Bahlanes Bakhtari
Plant-specific transcription factors known as WUSCHEL-related homeobox (WOX) proteins are crucial for regulating plant development and responses to stress. This study represents the first thorough characterization of the WOX gene family in ...
Identification of Progression-Associated Biomarkers in Lung Cancer Based on the Integrated Analysis of RNA Sequencing Data From Platelets and Tumor Tissues [0.03%]
基于血小板和肿瘤组织RNA测序数据的整合分析鉴定肺癌进展相关的生物标志物
Liancheng Lin,Xuemei Wu,Kangmei Dong et al.
Liancheng Lin et al.
Objective: This study is aimed at exploring disease progression-associated genes from platelet-derived genes and at investigating their underlying roles in prognostic outcomes in lung cancer. Methods: Platelet RNA sequencing (RNA-seq) from ...
Clinical and Genetic Functional Validation of a Novel AP1S1 Mutation Causing MEDNIK Syndrome [0.03%]
AP1S1新突变导致的MEDNIK综合征的临床和基因功能验证
Lifen Duan,Ru Shen,Guoyan Yin et al.
Lifen Duan et al.
Background: MEDNIK syndrome is a rare copper metabolism disorder caused by AP1S1 variants. Herein, we report the clinical and genetic characteristics of MEDNIK syndrome in two siblings. Methods: The clinical treatment process for MEDNIK syn...
Bioinformatics Analysis Reveals the Oncogenic Role and Therapeutic Potential of lncRNA SNHG25 in Colon Adenocarcinoma [0.03%]
生物信息学分析揭示长链非编码RNA SNHG25在结肠腺癌中的致癌作用和治疗潜力
Renshan Hao,Ye Zhang,Qi Zhu et al.
Renshan Hao et al.
Background: Colon adenocarcinoma (COAD) is a common digestive malignancy with limited therapies and a poor prognosis. Previous studies have highlighted lncRNAs' key role in cancer, but the exact function of lncRNA SNHG25 in COAD remains unc...
Impact of Genetic Polymorphisms on the Efficacy and Safety of Isoniazid in Saudi Tuberculosis Patients [0.03%]
基因多态性对沙特结核病患者异烟肼疗效和安全性的影响力
Mai A Alim A Sattar Ahmad,Huda Mohammed Alkreathy,Ahmed Ali et al.
Mai A Alim A Sattar Ahmad et al.
Introduction: Responses to antitubercular drugs like isoniazid (INH) are influenced by genetic polymorphisms in metabolizing enzymes and transporters. Objectives: This study is aimed at analyzing genetic polymorphisms of NAT2, CYP2E1, and G...