Multiomics Integration Reveals Coexpression Regulatory Networks in Osteoporosis and Osteosarcoma [0.03%]
多组学整合揭示骨质疏松和骨肉瘤中共表达调控网络
Dongming Fu,Ran Li,Bo Wang
Dongming Fu
Background: Osteoporosis and osteosarcoma impose a substantial and rising global health burden, yet their transcriptomic landscapes have not been systematically compared. We performed a multiomics characterization integra...
Causal Interplay Between Platelet Indices and Rheumatoid Arthritis: Genetic Evidence From Bidirectional Mendelian Randomization [0.03%]
血小板指标与类风湿性关节炎的因果互作：双向孟德尔随机化研究遗传证据
Xu-Yan Shen,Jia-Ying Sun,Xin Wang et al.
Xu-Yan Shen et al.
Objectives: This study is aimed at comprehensively understanding genetically causal associations between some platelet indices (PIs) and rheumatoid arthritis (RA). ...
Urinary Microbiota in Female Patients With Dry and Wet Overactive Bladder (OAB) [0.03%]
女性干型和湿型过度活跃膀胱综合征患者尿液微生物群的区别分析
Xiao Chen,Hui Zou,Jia Wang et al.
Xiao Chen et al.
Purpose: This study is aimed at comparing the urinary microbiota between OAB patients and healthy controls and at assessing whether urinary incontinence status affects the urinary microbiota in OAB patients. ...
Ubiquitin-Proteasome System-Related Prognostic Model and Immune Landscape in Glioblastoma [0.03%]
泛素-蛋白酶体系统相关预后模型及胶质母细胞瘤免疫图谱
Da Huo,Yue Feng,Zheng Yu et al.
Da Huo et al.
Background: Glioblastoma (GBM) is a highly aggressive brain tumor with poor prognosis. This study is aimed at establishing an ubiquitin-proteasome system (UPS)-related prognostic model and investigating its link to immune...
Single-Cell Transcriptomic Profiling Reveals Cellular Heterogeneity and Identifies Novel Therapeutic Targets in Osteosarcoma [0.03%]
单细胞转录组分析揭示骨肉瘤中的异质性并鉴定新型治疗靶点
Hui Li,Changjiang Sun,Minjie Yang
Hui Li
Background: Osteosarcoma is the most prevalent primary malignant bone tumor predominantly affecting children and adolescents, yet prognosis for metastatic disease remains dismal. Understanding the cellular complexity with...
Arg1 and Tgfb1 Identify a Partially Shared Macrophage Polarization Program in Postinfarction Cardiac Repair: A Single-Cell Transcriptomic Analysis [0.03%]
单细胞转录组分析识别出Arg1和Tgfb1在心梗后心脏修复中部分共有的巨噬细胞极化程序
Baobao Liu,Fuli Liang
Baobao Liu
Background: Postinfarction cardiac repair is orchestrated by macrophages that undergo sequential polarization from proinflammatory M1 to reparative M2 states. These macrophage subsets regulate inflammation resolution, ang...
Overexpression of lncRNA ATP11A-AS1 in Colorectal Cancer and Its Association With H. pylori Infection [0.03%]
长链非编码RNA ATP11A-AS1在结直肠癌中的过表达及其与幽门螺旋杆菌感染的关系
Nima Hagholshahri,Nashwah Jabbar Kadhim Muttwaqi,Reza Safaralizadeh et al.
Nima Hagholshahri et al.
Background: Colorectal cancer (CRC), the third most common cancer globally, is a leading cause of cancer-related mortality. Helicobacter pylori infection, a risk factor for CRC, promotes carcinogenesis via inflammation an...
Genomic Identification and Comprehensive Characterization of the CAMTA Transcription Factor Family in Brassica rapa L [0.03%]
芸苔属植物生殖发育关键转录因子CAMTAs基因的鉴定和功能分析
Jannatul Afrin,Maria Chowdhory,Subroto Das Jyoti et al.
Jannatul Afrin et al.
Calmodulin-binding transcription activators (CAMTAs) are a key family of transcription factors that regulate gene expression involved in plant development and mediate plant responses to a wide range of biotic and abiotic stresses. Although ...
Genotype and Cardiac Rhabdomyoma Phenotype Analyses in Tuberous Sclerosis Complex Diseases [0.03%]
TSC相关心脏横纹肌瘤的基因型与表型分析
Xiang Chen,Ruen Yao,Wangtao Sheng et al.
Xiang Chen et al.
Background: Cardiac rhabdomyomas (CRs) are one of the typical phenotypes of tuberous sclerosis complex (TSC) diseases. Patients with CR could present various phenotypes and different severities. TSC1 and TSC2 are candidat...
De Novo Transcriptomic Profiling of Piper chaba: Elucidating the Genetic Basis of Piperine Biosynthesis and Metabolic Pathways [0.03%]
从头转录组分析胡椒属植物Piper chaba：阐明胡椒碱生物合成及代谢途径的遗传基础
Deeksha Singh,Shivangi Mathur,Rajiv Ranjan
Deeksha Singh
Medicinal plants serve as invaluable sources of bioactive compounds, yet the molecular basis of their secondary metabolite biosynthesis remains largely unexplored. Piper chaba Hunter, an important but understudied member of the Piperaceae f...