Effect of sildenafil on resting and exercise haemodynamics in hypoxia in patients with pulmonary vascular diseases: data from a randomised controlled trial [0.03%]
一项随机对照试验中关于西地那非对肺血管疾病患者静息及运动血动力学在低氧环境中影响的数据分析
Mona Lichtblau,Simon R Schneider,Julian Müller et al.
Mona Lichtblau et al.
In patients with PH exposed to simulated ∼2500-m hypoxia, a single 50-mg sildenafil dose had no effect at rest but reduced exercise-induced pulmonary pressure and resistance, potentially improving exercise capacity during hypoxic exposure ...
"Good health" and care needs in idiopathic pulmonary fibrosis/progressive pulmonary fibrosis: the COCOS-IPF patient-led European focus groups [0.03%]
特发性肺纤维化/进行性肺纤维化的"良好健康"和护理需求：COCOS-IPF患者主导的欧洲焦点小组的意见
Silja Schenk,Jeanette Boyd,Fabienne Dobbels et al.
Silja Schenk et al.
Background: Idiopathic pulmonary fibrosis (IPF) and other progressive forms of pulmonary fibrosis (PPF) place a heavy burden on patients' lives. While research on clinical aspects of IPF and PPF progresses, evidence on pa...
The association between chronic rhinosinusitis, bronchiectasis and type 2 inflammation: an EMBARC registry analysis [0.03%]
慢性鼻窦炎、支气管扩张和2型炎症之间的关系：EMBARK注册研究分析结果
Michal Shteinberg,Charles S Haworth,Jennifer Pollock et al.
Michal Shteinberg et al.
Introduction: Chronic rhinosinusitis (CRS) is a common comorbidity in bronchiectasis. Previous studies suggested that bronchiectasis with CRS is associated with elevated type 2 biomarkers, representing an "eosinophilic br...
Clinical phenotypes in α1-antitrypsin deficiency: a cluster analysis on EARCO data [0.03%]
α1-抗胰蛋白酶缺乏症的临床表型：EARCO 数据的聚类分析
Anse Somers,Kenneth Verstraete,Ella Demesmaeker et al.
Anse Somers et al.
Background: α-1 antitrypsin deficiency (AATD) is a rare, monogenic disorder predisposing individuals to liver and lung diseases. Yet, even within the same genotype, AATD is very heterogeneous in clinical presentation. Th...
Characteristics of severe disease in granulomatous lymphocytic interstitial lung disease: a retrospective cohort study [0.03%]
肉芽肿性淋巴细胞性间质性肺病重症患者的临床特征：回顾性队列研究
Kale S Bongers,Angeline Massett,Smita Patel et al.
Kale S Bongers et al.
Baseline pulmonary function tests, oxygen supplementation, and reticulation, honeycombing and consolidation on chest CT scans are associated with worse outcomes in granulomatous lymphocytic interstitial lung disease https://bit.ly/3MtmVFd. ...
Real-world characterisation of severe asthma in Greece: results from the Greek Severe Asthma Registry [0.03%]
希腊重度哮喘的真实世界特征：希腊重度哮喘登记处结果分析
Evangelia Fouka,Maria Kallieri,Pantelis Avarlis et al.
Evangelia Fouka et al.
Background: Severe asthma (SA) imposes a disproportionate burden on patients and healthcare systems worldwide, yet region-specific data from Southern Europe remain scarce. The Greek Severe Asthma Registry (GSAR), an initi...
Patient perspectives on ultrasound-guided interventions in respiratory medicine: an international, mixed-methods study [0.03%]
呼吸医学中超声引导介入的患者视角：一项国际混合研究方法研究
Elisa Jones,Stefano Pavanello,Dinesh Addala et al.
Elisa Jones et al.
Background: In recent decades the use of thoracic ultrasound (US) in respiratory medicine has expanded, moving from the near-exclusive domain of radiologists to an indispensable tool for clinicians in the diagnosis and ma...
Eosinophil subtypes in asthmatic patients treated with mepolizumab, omalizumab and dupilumab [0.03%]
接受美泊利单抗、奥马珠单抗和杜匹鲁单抗治疗的哮喘患者的嗜酸性粒细胞亚型分析
Carlos Cabrera López,Alejandra Sánchez Santos,Angelina Lemes Castellano et al.
Carlos Cabrera López et al.
Introduction: Two eosinophil subtypes, resident (rEos) and inflammatory (iEos), have been identified, first in mice and later in asthmatic patients. The effects of different biologics on these subpopulations remain unclea...
Structure and function imaging in primary ciliary dyskinesia: cross-sectional study with 129Xe ventilation/1H anatomical magnetic resonance imaging [0.03%]
以129Xe通气和氢质子解剖磁共振成像进行原发性纤毛运动障碍的结构与功能显影：横断面研究
Lynne Schofield,Laurie Smith,Helen Marshall et al.
Lynne Schofield et al.
Background: In primary ciliary dyskinesia (PCD), impaired mucociliary clearance leads to respiratory infections. Whilst forced expiratory volume in 1 s (FEV1) is commonly used to evaluate lung function in PCD its sensitiv...
Genetic variants underpinning lung function decline in the Lifelines general population cohort study [0.03%]
在Lifelines一般人群队列研究中指导肺功能下降的遗传变异体
Rui Marçalo,Corry-Anke Brandsma,Peter J van der Most et al.
Rui Marçalo et al.
Rationale: Variations in age-related lung function decline are associated with genetic and environmental factors. The genetic variants contributing to this decline remain largely unknown, limiting the understanding of ind...