Lipid profiling in nontuberculous mycobacterial pulmonary disease based on geospatial locations and disease severity [0.03%]
基于地理位置和疾病严重程度的非结核分枝杆菌肺病脂质组学特征研究
Jungeun Kim,Kyeong-Seog Kim,Jaemoon Koh et al.
Jungeun Kim et al.
Background: The role of lipid profiles in the pathogenesis of nontuberculous mycobacterial pulmonary disease (NTM-PD) remains largely unexplored. This study aimed to identify lipid profile variations across geospatial lun...
Diversity and inclusivity in clinical trial populations for maintenance inhaler therapy in people with COPD: a systematic review [0.03%]
慢性阻塞性肺病患者维持期吸入疗法临床试验人群的多样性与包容性系统评价
Harrison Birch,Amy Pascoe,Amy McCormick et al.
Harrison Birch et al.
Background: Social determinants of health (SDH) influence COPD prevalence, progression and treatment, yet their inclusion in clinical trials is poorly understood. This study examined recruitment strategies for diverse pop...
ETB receptor deficiency amplifies allergic airway inflammation and hyperresponsiveness [0.03%]
ETB受体缺乏加剧过敏性气道炎症和高反应性
Christoph Tabeling,Carla R González Calera,Birgitt Gutbier et al.
Christoph Tabeling et al.
Background: Endothelin-1 (ET-1) is a proinflammatory mediator that plays a crucial role in regulating airway tone by activating G protein-coupled endothelin receptors A (ETA) and B (ETB). The endothelin system has been li...
Transforming post-acute pneumonia management: risk stratification using machine learning [0.03%]
基于机器学习的肺炎亚急性期管理风险分层研究
Catia Cilloniz,Mads Lause Mogensen,Logan Ward
Catia Cilloniz
The application of machine learning in patients with community-acquired pneumonia allows the identification of high-risk phenotypes for post-acute mortality, improving the limitations of classical severity scores and personalised patient ma...
The impact of positive airway pressure treatment on mortality and hospitalisation in obstructive sleep apnoea: a German database analysis [0.03%]
德国数据库分析：正压通气治疗对阻塞性睡眠呼吸暂停患者死亡率和住院率的影响
Holger Woehrle,Michael Arzt,Joachim H Ficker et al.
Holger Woehrle et al.
Background: Obstructive sleep apnoea (OSA) is a prevalent disorder. No consistent mortality benefit from treating OSA has been reported in randomised controlled trials. This analysis of an age-and-sex-representative anony...
Real-world effectiveness of biologic therapies in severe asthma patients ineligible for phase 3 randomised controlled trials of biologics: an analysis from the UK Severe Asthma Registry [0.03%]
英国重度哮喘注册表中生物制剂三期随机对照试验不符合条件的重度哮喘患者使用生物制剂的疗效分析
Paul E Pfeffer,Jola Karaj,Thomas Brown et al.
Paul E Pfeffer et al.
Background: Most patients in real-world severe asthma populations would not be eligible for biologic randomised controlled trials (RCTs), although observational evidence has confirmed the effectiveness of biologics in rea...
Mucociliary and cough clearance in primary ciliary dyskinesia as affected by mutations in RSPH1 or DNAH5 [0.03%]
RSPH1或DNAH5突变对原发性纤毛运动障碍患者黏液清除功能的影响
Lawrence E Ostrowski,Sara Abu-Nasser,Kirby L Zeman et al.
Lawrence E Ostrowski et al.
Background: Primary ciliary dyskinesia (PCD) is a rare disease caused by mutations in >50 genes that impair the function of motile cilia. The clinical phenotype is heterogeneous and recent studies have begun to investigat...
Clinical characteristics of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia [0.03%]
弥漫性特发性肺神经内分泌细胞增生症的临床特征
Marissa O&#x;Callaghan,Sarah H Forde,Alessandro N Franciosi et al.
Marissa O&#x;Callaghan et al.
Rationale: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is characterised by diffuse bronchial hyperplasia of pulmonary neuroendocrine cells, which are situated within the walls of bronchi and bro...
Risk stratification as a guide to goal-oriented management of patients with fibrotic interstitial lung disease: a registry-based analysis [0.03%]
基于注册表的分析指导纤维化间质性肺疾病患者目标导向管理的风险分层研究
Jürgen Behr,Antje Prasse,Hubert Wirtz et al.
Jürgen Behr et al.
Introduction: Idiopathic pulmonary fibrosis (IPF) has high morbidity and mortality with limited treatment options. Goal-oriented management approaches, such as the "treatable traits" concept, have yet to be implemented in...
Safety and efficacy of upfront triple therapy including parenteral treprostinil compared to double oral therapy in PAH (TripleTRE): study protocol for a randomised trial [0.03%]
初始联合应用曲前列环素的三联疗法与口服双药联合疗法在肺动脉高压患者中的疗效及安全性研究（Triple-TRE试验）：随机对照试验方案
Olivier Sitbon,Gergely Agoston,Roberto Badagliacca et al.
Olivier Sitbon et al.
Background: Pulmonary arterial hypertension (PAH) requires a complex and multidisciplinary care approach with regular follow-up visits to monitor disease progression and adaptation of treatment regimens. Current ESC/ERS G...