Shifting focus to phenotypes: the evolution of long COVID rehabilitation [0.03%]
聚焦表型的转变：长期新冠肺炎康复治疗的发展演化
Rainer Gloeckl,Rachael A Evans
Rainer Gloeckl
Modern long COVID rehabilitation must go beyond improving exercise capacity. It must serve as behavioural and physiological mediator enabling the "adaptive middle ground": a precise zone of symptom-titrated activity to navigate sustainable ...
Sneha Chakraverty,Nikolas Chynkiamis,Neha Maru et al.
Sneha Chakraverty et al.
Background: The long-term effects of rehabilitation in individuals with long COVID remain unclear. This systematic review and meta-analysis evaluated the short- and long-term impacts of rehabilitation programmes on exerci...
Clinical utility of sputum cytology in severe asthma: insights from a specialist centre [0.03%]
严重哮喘患者痰液细胞学的临床应用价值：专科中心的研究启示
Sunera Khan,Sharron Gilbey,Muna Sheego et al.
Sunera Khan et al.
Sputum cytology can be successfully implemented in routine severe asthma care, providing critical information on airway inflammation beyond blood eosinophils or F ENO to guide more precise, phenotype-driven treatment decisions https://bit.l...
Jo Vi Lim,Chris RuiWen Kuo,Rory Chan
Jo Vi Lim
Oscillometry-defined small airway dysfunction (SAD) is prevalent in severe asthma and may improve with tezepelumab. This real-world study supports SAD as a clinically relevant, treatable trait and proposes oscillometry as a complementary as...
Improvements in small airway dysfunction and respiratory symptoms following tezepelumab for severe asthma [0.03%]
-tezepelumab治疗重度哮喘后小气道功能障碍和呼吸症状的改善
Aviv Kupershmidt,Gal Elkayam,Nimrod Urtreger et al.
Aviv Kupershmidt et al.
Background: Small airway dysfunction (SAD) is a key feature of severe asthma, contributing to poor symptom control and exacerbations. Tezepelumab has demonstrated efficacy in reducing exacerbations and improving lung func...
Automatic oxygen titration during exercise in pulmonary rehabilitation: a pilot trial [0.03%]
运动时自动调节吸氧浓度在肺康复中的试点研究
Tessa Schneeberger,Inga Jarosch,Rainer Gloeckl et al.
Tessa Schneeberger et al.
Automatic oxygen titration resulted in similar dyspnoea and physiological responses to prescribed constant-flow oxygen during exercise in pulmonary rehabilitation and was safe, suggesting potential to improve oxygen prescription in clinical...
Lung cancer in interstitial lung disease: a matched case-control and cohort analysis [0.03%]
特发性肺纤维化人群中的肺癌流行病学研究：队列及病例对照研究
Megan Harrison,Vidya Navaratnam,Francesca Gonnelli et al.
Megan Harrison et al.
Background: Lung cancer is significantly more common in patients with idiopathic pulmonary fibrosis (IPF) than the general population. Whether this risk extends to other fibrotic interstitial lung diseases (ILDs) includin...
SM17, an anti-interleukin-17 receptor B antibody, ameliorates pathogenesis of chronic rhinosinusitis with nasal polyps and idiopathic pulmonary fibrosis via Th2/Th17 dual modulation [0.03%]
SM17通过调节Th2/Th17改善慢性鼻窦炎和特发性肺纤维病的病理生成，SM17是一种抗IL-17RB抗体
Lik Hang Lam,Weimin Li,Kai Cheung Chow et al.
Lik Hang Lam et al.
Background: Chronic respiratory diseases (CRDs), driven by dysregulated Th2/Th17 inflammation, represent a global health challenge with limited therapeutic options. Interleukin (IL)-25 has emerged as a key upstream regula...
The development of a digital pathway for the assessment of residual excessive daytime sleepiness in obstructive sleep apnoea: a service evaluation [0.03%]
评估阻塞性睡眠呼吸暂停后日间过度嗜睡的数字化流程的开发：一项服务评价研究
Biswajit Chakrabarti,Bradley Freeman,Robert Angus et al.
Biswajit Chakrabarti et al.
Background: In the United Kingdom, national guidelines for obstructive sleep apnoea (OSA) highlight the importance of assessing continuous positive airways pressure (CPAP) compliance in order to identify patient cohorts o...
Peri-transplant frailty changes impact survival in interstitial lung diseases [0.03%]
移植前后体衰变化对间质性肺病患者生存率的影响
Stefan Kuhnert,Sabina Guler,Luise Wilke et al.
Stefan Kuhnert et al.
Background: Frailty is a dynamic state of vulnerability resulting from progressive functional decline and multimorbidity in patients with interstitial lung disease (ILD). The effect of lung transplantation (LTx) on frailt...