LncRNA 3222401L13Rik Is Upregulated in Aging Astrocytes and Regulates Neuronal Support Function Through Interaction with Npas3 [0.03%]
长非编码RNA 3222401L13Rik在衰老星形胶质细胞中高表达并通过与Npas3互作调控神经元支持功能
Sophie Schröder,M Sadman Sakib,Dennis M Krüger et al.
Sophie Schröder et al.
Aging leads to cognitive decline and increased risk of neurodegenerative diseases. While molecular changes in central nervous system (CNS) cells contribute to this decline, the mechanisms are not fully understood. Long non-coding RNAs (lncR...
RNA Metabolism and the Role of Small RNAs in Regulating Multiple Aspects of RNA Metabolism [0.03%]
RNA代谢及小RNA在调控多种RNA代谢方面的功能
Pranav Dawar,Indra Adhikari,Swarupa Nanda Mandal et al.
Pranav Dawar et al.
RNA metabolism is focused on RNA molecules and encompasses all the crucial processes an RNA molecule may or will undergo throughout its life cycle. It is an essential cellular process that allows all cells to function effectively. The trans...
The 2024 Nobel Prize in Physiology or Medicine: microRNA Takes Center Stage [0.03%]
2024年诺贝尔生理学或医学奖：microRNA成为焦点
George A Calin,Florent Hubé,Michael R Ladomery et al.
George A Calin et al.
The Non-coding Journal Editorial Board Members would like to congratulate Victor Ambros and Gary Ruvkun, who were jointly awarded the 2024 Nobel Prize in Physiology or Medicine for their groundbreaking discovery of microRNAs and the role of...
Urinary miRNA Expression in Pre-Eclampsia During Early and Mid-Pregnancy [0.03%]
妊娠早期和中期子痫前期患者尿液miRNA表达谱的筛选及验证
Roman A Illarionov,Anastasia R Maltseva,Olga V Pachuliia et al.
Roman A Illarionov et al.
Background: Pre-eclampsia (PE) is a serious condition affecting 2-8% of pregnancies worldwide, leading to high maternal and fetal morbidity and mortality. MicroRNAs (miRNAs), small non-coding RNA molecules, have emerged as potential biomark...
Identification of Tumor-Suppressive miR-30a-3p Controlled Genes: ANLN as a Therapeutic Target in Breast Cancer [0.03%]
鉴定肿瘤抑制性miR-30a-3p靶基因：ANLN作为乳腺癌治疗靶点
Reiko Mitsueda,Ayako Nagata,Hiroko Toda et al.
Reiko Mitsueda et al.
Our recently created RNA-sequence-based microRNA (miRNA) expression signature in breast cancer clinical specimens revealed that some miR-30 family members were significantly downregulated in cancer tissues. Based on TCGA database analyses, ...
SVALKA: A Long Noncoding Cis-Natural Antisense RNA That Plays a Role in the Regulation of the Cold Response of Arabidopsis thaliana [0.03%]
拟南芥冷响应的长链顺式天然反义RNA SVALKA的作用机制研究
Nicholas M Kiger,Susan J Schroeder
Nicholas M Kiger
RNA plays important roles in the regulation of gene expression in response to environmental stimuli. SVALKA, a long noncoding cis-natural antisense RNA, is a key component of regulating the response to cold temperature in Arabidopsis thalia...
Detection of miR-133a-5p Using a Molecular Beacon Probe for Investigating Postmortem Intervals [0.03%]
用于研究死后间隔期的miR-133a-5p分子信标探针检测方法研究报告
Eun Hye Lee,Mingyoung Jeong,Kwangmin Park et al.
Eun Hye Lee et al.
Background: When a body is discovered at a crime or murder scene, it is crucial to examine the body and estimate its postmortem interval (PMI). Accurate estimation of PMI is vital for identifying suspects and providing clues to resolve the ...
Rick Kamps,Emma Louise Robinson
Rick Kamps
Primary mitochondrial disease (MD) is a group of rare genetic diseases reported to have a prevalence of 1:5000 and is currently without a cure. This group of diseases includes mitochondrial encephalopathy, lactic acidosis, and stroke-like e...
Androgen Receptor and Non-Coding RNAs' Interaction in Renal Cell Carcinoma [0.03%]
肾细胞癌中雄激素受体与非编码RNA的相互作用
Manal A Hussain,Noha M Elemam,Iman M Talaat
Manal A Hussain
Renal cell carcinoma (RCC), the most prevalent among the urogenital cancers, accounts for around 3% of new cancer cases worldwide. Significantly, the incidence of RCC has doubled in developed world countries, ranking it as the sixth most co...
Comparison of Three Computational Tools for the Prediction of RNA Tertiary Structures [0.03%]
三种RNA三级结构预测计算工具的比较
Frank Yiyang Mao,Mei-Juan Tu,Gavin McAllister Traber et al.
Frank Yiyang Mao et al.
Understanding the structures of noncoding RNAs (ncRNAs) is important for the development of RNA-based therapeutics. There are inherent challenges in employing current experimental techniques to determine the tertiary (3D) structures of RNAs...