Integrated Transcriptomic, In Silico, and In Vitro Characterization of lncRNA ENST00000615487.1 Reveals Epithelial-Specific Expression, Differential Subcellular Distribution Between Normal and Colorectal Cancer Cells, and Potential Regulatory Functions [0.03%]
整合转录组、计算机模拟和体外实验表征ENST00000615487.1 lncRNA，揭示其上皮特异性表达，在正常细胞和结直肠癌细胞间的亚细胞分布差异以及潜在的调控功能
Nataša Đokić,Anastasija Bubanja,Jelena Karanović et al.
Nataša Đokić et al.
Background/Objectives: Long non-coding RNAs (lncRNAs) are important regulators of tumor biology through their interactions with DNA, proteins, and non-coding RNAs. Although ENST00000615487.1 (also known as CTD-2396E7.11/AC010503.4) has been...
Francisco J Enguita,Suresh K Alahari,Luca Agnelli et al.
Francisco J Enguita et al.
We are delighted to share with you our fifteenth Journal Club and highlight some of the most interesting papers published recently [...].
A Mathematical Approach on the Limits of ceRNA Hypothesis Through an Ordinary Differential Equations (ODE) Model of mRNA-microRNA Interactions [0.03%]
运用常微分方程模型定量研究基因mRNA与miRNA的相互作用以及从数学角度探讨ceRNA假说的局限性
Paul Flondor,Mircea Olteanu,Radu Stefan et al.
Paul Flondor et al.
Background: MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression post-transcriptionally by binding to target messenger RNAs (mRNAs) and suppressing their expression. Competing endogenous RN...
P22 Small Noncoding RNAs Are Actively Secreted in Salmonella Outer Membrane Vesicles During Bacteriophage Infection [0.03%]
副溶血弧菌噬菌体感染时P22小型非编码RNA在副溶血弧菌外膜囊泡中主动分泌
Sayema Naaz,Haley A Kominek,Lydia A Hayes-Guastella et al.
Sayema Naaz et al.
Background/Objectives: Outer membrane vesicles (OMVs) are membrane-encapsulated spherical structures ~120 nm in diameter derived from Gram-negative bacterial cell envelopes. OMVs are primarily generated by outer membrane blebbing but contai...
An Optimized RT-qPCR Protocol for Comprehensive Analysis of microRNAs and mRNAs in Mus musculus Brain Tissues [0.03%]
小鼠脑组织中microRNAs和mRNAs全面分析的优化RT-qPCR方案
Maria V Lukashevich,Margarita M Rudenok,Suzanna A Partevian et al.
Maria V Lukashevich et al.
Background/Objectives: MicroRNAs are key post-transcriptional regulators involved in various diseases. Despite its status as the gold standard, real-time RT-PCR faces challenges arising from high sequence homology among closely related micr...
Investigation of Long Non-Coding RNAs H19 rs3741219, MEG3 rs7158663, POLR2E rs3787016, and ANRIL rs10757274 with Breast Cancer Susceptibility and Clinicopathological Characteristics in a Mexican Population [0.03%]
墨西哥人群长链非编码RNA H19 rs3741219、MEG3 rs7158663、POLR2E rs3787016和ANRIL rs10757274与乳腺癌易感性和临床病理特征的相关性研究
Mónica Alejandra Rosales-Reynoso,Anilú Margarita Saucedo-Sariñana,Clara Ibet Juárez-Vázquez et al.
Mónica Alejandra Rosales-Reynoso et al.
Recent evidence has highlighted the crucial role of non-coding genetic elements in regulating gene expression and has been linked to a broad range of biological functions. Notably, dysregulation of long non-coding RNAs has been strongly ass...
Comprehensive lincRNA Transcriptome in Acute Myeloid Leukemia: Integrating Known and Newly Identified lincRNAs Across Pediatric and Adult Cohorts [0.03%]
急性髓系白血病中的全面长链非编码RNA转录组：整合已知和新鉴定的长链非编码RNA跨越儿童和成人队列
Saioa Arza-Apalategi,Daan Gilissen,Anne C van der Grinten et al.
Saioa Arza-Apalategi et al.
Background/Objectives: Acute myeloid leukemia (AML) comprises genetic subclasses with distinct gene expression profiles. While AML gene expression studies have mainly focused on protein-coding genes, our understanding of expression patterns...
Exploratory Machine Learning Analysis of circRNA-Derived Molecular Features in Autism Spectrum Disorder [0.03%]
自闭症谱系障碍中circRNA衍生分子特征的探索性机器学习分析
Raunak Sharda,Valentina L Kouznetsova,Igor F Tsigelny
Raunak Sharda
Background/Objectives: Autism Spectrum Disorder (ASD) is a set of neurological and neurodevelopmental disorders characterized by difficulties in social communication and interaction, repetitive behaviors, and sensory processing differences....
Urinary Exosomal microRNAs as a Novel Approach to Study People with Multiple Sclerosis and Severe Gait Disability: A Preliminary Observation [0.03%]
尿液外泌体microRNA作为研究多发性硬化症患者重度步态残疾的新方法：初步观察结果
Silvia Grassilli,Andrea Baroni,Marina Pierantoni et al.
Silvia Grassilli et al.
Background: MiRNAs within extracellular vesicles can encompass body barriers, reflecting stage, progression, and response to treatments of various diseases, including multiple sclerosis (MS)-a chronic immune-mediated disease of the central ...
Hnf1aos1 as a Metabolic Coordinator of Hepatic Lipid Homeostasis and Feedback Control [0.03%]
Hnf1aos1作为肝脏脂质稳态和反馈调控的代谢协调因子
Beshoy Armanios,Jing Jin,Ankit P Laddha et al.
Beshoy Armanios et al.
Background: Long noncoding RNAs (lncRNAs) have emerged as critical regulators of hepatic metabolism and disease progression. The hepatocyte nuclear factor 1 alpha antisense 1 (HNF1A-AS1) lncRNA modulates liver-specific transcription factors...