Functional and Molecular Characterization of Extracellular Vesicles Enriched in Exosomes Released by Bone Marrow Mesenchymal Stromal Cells Exposed to IFNγ in Combination with Autophagy Modulators Tamoxifen or Chloroquine [0.03%]
干扰素γ联合自噬调节剂他莫昔芬或氯喹处理后骨髓间充质基质细胞释放的外泌体的功能和分子特征及其富集的细胞外囊泡的功能和分子特征的表征
Vladimir Beljanski,Maria J Moreno Hollweg,Renee Potens et al.
Vladimir Beljanski et al.
Background/Objectives: Bone marrow mesenchymal stromal cells (MSCs) are therapeutic cells that adopt an immunomodulatory phenotype when exposed to pro-inflammatory cytokines. Recent research efforts uncovered that many therapeutic benefits ...
The Role of microRNAs as Potential Biomarkers in Diffuse Large B-Cell Lymphoma [0.03%]
微RNA作为弥漫性大B细胞淋巴瘤潜在生物标志物的作用研究进展
Eirini Panteli,Epameinondas Koumpis,Vasileios Georgoulis et al.
Eirini Panteli et al.
Diffuse large B-cell lymphoma (DLBCL) is the most common and clinically aggressive subtype of non-Hodgkin lymphoma (NHL). While novel therapies such as rituximab and polatuzumab vedotin have led to improved outcomes, approximately 35% of pa...
Transposable Element-Derived miR-28-5p and miR-708-5p: Exploring Potential Roles in Lung Cancer [0.03%]
可移动元件来源的miR-28-5p和miR-708-5p：探究在肺癌中的潜在功能作用
Sergiu Chira,Cornelia Braicu,Stefan Strilciuc et al.
Sergiu Chira et al.
Background: Transposable elements are normally silenced by epigenetic mechanisms; however, during malignant transformation, epigenetic alterations enable transposons to produce functional molecules like miRNAs. Among these, LINE-2 (L2) elem...
MicroRNAs in Breast Cancer Bone Metastasis Formation and Progression: An Overview on Recent Progress in This Research Field [0.03%]
微小核糖核酸与乳腺癌骨转移：近期研究进展概述
Margherita Puppo
Margherita Puppo
Bone metastasis is a common and severe complication in advanced stages of breast cancer (BC) that is characterised by limited treatment options and poor patient prognosis. MicroRNAs (miRNAs) are a large class of regulatory small non-coding ...
Morgane Gourvest,Coen van Solingen
Morgane Gourvest
CARINH is an intriguing long noncoding RNA whose unique regulatory functions intersect the seemingly distinct processes of innate immunity and cancer development. Notably, CARINH is conserved across species, offering powerful experimental m...
miRNA and Its Implications in the Treatment Resistance in Breast Cancer-Narrative Review of What Do We Know So Far [0.03%]
微小核糖核酸与乳腺癌治疗抵抗的相关性——迄今为止的叙述性综述
Isabela Anda Komporaly,Adelina Silvana Gheorghe,Lidia Anca Kajanto et al.
Isabela Anda Komporaly et al.
Breast cancer remains a leading cause of cancer-related mortality worldwide, with treatment resistance and tumor heterogeneity posing major clinical challenges. MicroRNAs (miRNAs), small non-coding RNAs regulating gene expression, have emer...
Akari Fukumoto,Moeka Nakashima,Satoru Matsuda
Akari Fukumoto
Food is a crucial component affecting the health of individuals, which may have the potential to expand lifespan. It has been shown that a long lifespan may be related to fine-tuned autophagy. In general, suitable autophagy could play a sig...
Evaluation of Expression and Clinicopathological Relevance of Small Nucleolar RNAs (snoRNAs) in Invasive Breast Cancer [0.03%]
侵袭性乳腺癌中小核仁RNA(snoRNAs)的表达及临床病理意义评估
Luděk Záveský,Eva Jandáková,Vít Weinberger et al.
Luděk Záveský et al.
Background/Objectives: Breast cancer is a leading cause of cancer-related mortality among women worldwide. Small nucleolar RNAs (snoRNAs) represent a class of non-coding RNAs with potential as novel biomarkers applicable to improve diagnost...
El Cheima Mhamedi,Florent Hubé,Suresh K Alahari et al.
El Cheima Mhamedi et al.
The field of non-coding RNA research is advancing at a breathtaking pace, continually uncovering new layers of regulatory complexity and functional diversity [...].
The Chromosome 19 microRNA Cluster Facilitates Cancer Stemness in Hepatocellular Carcinoma [0.03%]
染色体19的微小核糖核酸簇可促进肝细胞癌干细胞样特性
Marian T Underwood,Varsha Devarapalli,Goodwin G Jinesh et al.
Marian T Underwood et al.
Background/Objectives: Hepatocellular carcinoma (HCC) is one of the world's deadliest cancers; however, the mechanisms that contribute to its aggressiveness are poorly understood. In the recent literature, overexpression of the Chromosome 1...