The Role of Non-Coding RNAs in MYC-Mediated Metabolic Regulation: Feedback Loops and Interactions [0.03%]
非编码RNA在MYC介导的代谢调节中的作用：反馈环和相互作用
Aliaa Amr Alamoudi
Aliaa Amr Alamoudi
Metabolic reprogramming is a hallmark of cancer, crucial for supporting the rapid energy demands of tumor cells. MYC, often deregulated and overexpressed, is a key driver of this shift, promoting the Warburg effect by enhancing glycolysis. ...
A miRNA Signature for Non-Invasive Colorectal Cancer Diagnosis in Morocco: miR-21, miR-29a and miR-92a [0.03%]
摩洛哥非侵入性结直肠癌诊断的miRNA特征：miR-21，miR-29a和miR-92a
Sofia Fathi,Oussama Aazzane,Salma Guendaoui et al.
Sofia Fathi et al.
Colorectal cancer (CRC) is the third most diagnosed cancer and a leading cause of cancer-related mortality in Morocco, often detected at late stages. Circulating microRNAs (miRNAs) have emerged as promising non-invasive biomarkers for CRC d...
Chromatin Structure Around Long Non-Coding RNA (lncRNA) Genes in Schistosoma mansoni Gonads [0.03%]
血吸虫 gonad 中长非编码 RNA(lncRNA) 基因周围的染色质结构
Ronaldo C Augusto,Thomas Quack,Christoph G Grevelding et al.
Ronaldo C Augusto et al.
In this study, we employed a total of eight distinct modifications of histone proteins (H3K23ac, H3K27me3, H3K36me3, H3K4me3, H3K9ac, H3K9me3, H4K12ac, and H4K20me1) to discern the various chromatin colors encompassing lncRNA genes in both ...
Single-Cell Transcriptomic Approaches for Decoding Non-Coding RNA Mechanisms in Colorectal Cancer [0.03%]
单细胞转录谱在结肠癌非编码RNA机制解码中的应用
Mahnoor Naseer Gondal,Hafiz Muhammad Umer Farooqi
Mahnoor Naseer Gondal
Non-coding RNAs (ncRNAs) play crucial roles in colorectal cancer (CRC) development and progression. Recent developments in single-cell transcriptome profiling methods have revealed surprising levels of expression variability among seemingly...
A Multi-Input Neural Network Model for Accurate MicroRNA Target Site Detection [0.03%]
用于精确的microRNA靶位点检测的多输入神经网络模型
Mohammad Mohebbi,Amirhossein Manzourolajdad,Ethan Bennett et al.
Mohammad Mohebbi et al.
(1) Background: MicroRNAs are non-coding RNA sequences that regulate cellular functions by targeting messenger RNAs and inhibiting protein synthesis. Identifying their target sites is vital to understanding their roles. However, it is chall...
Elena Golovina,Cory Eaton,Virginia Cox et al.
Elena Golovina et al.
Circular RNAs (circRNAs) make up approximately 10% of the human transcriptome. CircRNAs belong to the broad group of non-coding RNAs and characteristically are formed by backsplicing into a stable circular loop. Their main role is to regula...
MicroRNAs: A Novel Approach for Monitoring Treatment Response in Major Depressive Disorder? [0.03%]
microRNA：一种检测主要抑郁症治疗反应的新方法？
Cristina-Sorina Cătană,Monica Mihaela Marta,Daniel Ungureanu et al.
Cristina-Sorina Cătană et al.
Major depressive disorder (MDD) is one of the most prevalent psychiatric disorders, with an increasing incidence each year and an important socioeconomic burden. Although new treatments are continuously being developed, there is no effectiv...
The Unpaved Road of Non-Coding RNA Structure-Function Relationships: Current Knowledge, Available Methodologies, and Future Trends [0.03%]
非编码RNA结构功能关系的未铺之路：目前的知识，可用的方法和技术趋势
Ana Lúcia Leitão,Francisco J Enguita
Ana Lúcia Leitão
The genomes from complex eukaryotes are enriched in non-coding genes whose transcription products (non-coding RNAs) are involved in the regulation of genomic output at different levels. Non-coding RNA action is predominantly driven by seque...
The Emerging Applications of Artificial MicroRNA-Mediated Gene Silencing in Plant Biotechnology [0.03%]
人工微小核糖核酸介导的基因沉默在植物生物技术中的新兴应用
Luis Alberto Bravo-Vázquez,Ana Marta Castro-Pacheco,Rodrigo Pérez-Vargas et al.
Luis Alberto Bravo-Vázquez et al.
Improving crop yield potential is crucial to meet the increasing demands of a rapidly expanding global population in an ever-changing and challenging environment. Therefore, different technological approaches have been proposed over the las...
Secondary-Structure-Informed RNA Inverse Design via Relational Graph Neural Networks [0.03%]
基于二级结构信息的通过关系图神经网络的RNA逆向设计
Amirhossein Manzourolajdad,Mohammad Mohebbi
Amirhossein Manzourolajdad
RNA inverse design is an essential part of many RNA therapeutic strategies. To date, there have been great advances in computationally driven RNA design. The current machine learning approaches can predict the sequence of an RNA given its 3...