Small RNA Landscape of Platelet Dust: Platelet-Derived Extracellular Vesicles from Patients with Non-Small-Cell Lung Cancer [0.03%]
非小细胞肺癌患者血小板衍生的外泌体中的小RNA图谱
Mafalda Antunes-Ferreira,Ilias Glogovitis,Diogo Fortunato et al.
Mafalda Antunes-Ferreira et al.
Background: Platelet-derived Extracellular Vesicles, or "Platelet Dust" (PD), are reported as the most-abundant extracellular vesicles in plasma. However, the PD molecular content, especially the small RNA profile, is still poorly character...
Tiny but Mighty: Small RNAs-The Micromanagers of Bacterial Survival, Virulence, and Host-Pathogen Interactions [0.03%]
小小却强大：小RNA——细菌存活、致病性和宿主-病原体相互作用的微管理者
Rajdeep Banerjee
Rajdeep Banerjee
Bacterial pathogens have evolved diverse strategies to infect hosts, evade immune responses, and establish successful infections. While the role of transcription factors in bacterial virulence is well documented, emerging evidence highlight...
Maria Jose Navarro-Cobos,Carolyn J Brown
Maria Jose Navarro-Cobos
Dimorphism of sex chromosomes often leads to a need for dosage compensation. In eutherian mammals, XIST, a long non-coding RNA, is expressed from the X chromosome that will be silenced, triggering X-chromosome inactivation (XCI). XIST origi...
Building a Hand-Curated ceRNET for Endometrial Cancer, Striving for Clinical as Well as Medicolegal Soundness: A Systematic Review [0.03%]
力求临床和医疗法律完善：构建手工整理的子宫内膜癌ceRNET系统性回顾
Roberto Piergentili,Stefano Sechi,Lina De Paola et al.
Roberto Piergentili et al.
Background/Objectives: Competing endogenous RNAs (ceRNA) are molecules that compete for the binding to a microRNA (miR). Usually, there are two ceRNA, one of which is a protein-coding RNA (mRNA), with the other being a long non-coding RNA (...
Bromodomain and Extra-Terminal Family Proteins BRD2, BRD3, and BRD4 Contribute to H19-Dependent Transcriptional Regulation of Cell Adhesion Molecules, Modulating Metastatic Dissemination Program in Prostate Cancer [0.03%]
溴结构域和末端外家族蛋白BRD2、BRD3和BRD4通过H19调节细胞粘附分子转录，从而调控前列腺癌转移扩散程序
Valeria Pecci,Melissa Borsa,Aurora Aiello et al.
Valeria Pecci et al.
Background/objectives: Metastatic prostate cancer (PCa) remains a major clinical challenge with limited therapeutic options. The long non-coding RNA H19 has been implicated in regulating cell adhesion molecules and collec...
In Silico Prioritization of STAT1 3' UTR SNPs Identifies rs190542524 as a miRNA-Linked Variant with Potential Oncogenic Impact [0.03%]
计算优先处理STAT1 3'UTR SNP确定与miRNA相关的具有潜在致癌作用的变异(rs190542524)
Ebtihal Kamal
Ebtihal Kamal
Background: Single-nucleotide polymorphisms (SNPs) are associated with multiple disorders and various cancer types. In the context of cancer, alterations within non-coding regions, specifically 3' untranslated regions (3'...
Role of Long Non-Coding RNA X-Inactive-Specific Transcript (XIST) in Neuroinflammation and Myelination: Insights from Cerebral Organoids and Implications for Multiple Sclerosis [0.03%]
长非编码RNA X染色体失活特异性转录本(XIST)在神经炎症和髓鞘形成中的作用：源自脑类器官的多发性硬化症研究新见解
Nihan Aktas Pepe,Busra Acar,Gozde Erturk Zararsiz et al.
Nihan Aktas Pepe et al.
Background/Objectives: X-inactive-specific transcript (XIST) is a factor that plays a role in neuroinflammation. This study investigated the role of XIST in neuronal development, neuroinflammation, myelination, and therapeutic responses wit...
Role of Non-Coding RNAs in White and Brown Adipose Tissue Differentiation and Development [0.03%]
非编码RNA在白色和棕色脂肪组织分化及发育中的作用
Lea Sleiman,Sorina Dinescu
Lea Sleiman
Adipocyte differentiation is a complex process in which pluripotent mesenchymal stem cells (MSCs) differentiate and develop into mature fat cells, also known as adipocytes. This process is controlled by various transcription factors, hormon...
Annanda Lyra Ribeiro,Bruno Dallagiovanna
Annanda Lyra Ribeiro
The human genome sequencing revealed a vast complexity of transcripts, with over 80% of the genome being transcribed into non-coding RNAs. In particular, long non-coding RNAs (lncRNAs) have emerged as critical regulators of various cellular...
Decoding Salivary ncRNAomes as Novel Biomarkers for Oral Cancer Detection and Prognosis [0.03%]
解码唾液ncRNA组作为口腔癌检测和预后的新生物标志物
Subhadeep Das,Sampad Basak,Soumyadev Sarkar
Subhadeep Das
Oral cancer (OC) ranks among the most prevalent head and neck cancers, becoming the eleventh most common cancer worldwide with ~350,000 new cases and 177,000 fatalities annually. The rising trend in the occurrence of OC among young individu...