In Silico Prioritization of STAT1 3' UTR SNPs Identifies rs190542524 as a miRNA-Linked Variant with Potential Oncogenic Impact [0.03%]
计算优先处理STAT1 3'UTR SNP确定与miRNA相关的具有潜在致癌作用的变异(rs190542524)
Ebtihal Kamal
Ebtihal Kamal
Background: Single-nucleotide polymorphisms (SNPs) are associated with multiple disorders and various cancer types. In the context of cancer, alterations within non-coding regions, specifically 3' untranslated regions (3'...
Role of Long Non-Coding RNA X-Inactive-Specific Transcript (XIST) in Neuroinflammation and Myelination: Insights from Cerebral Organoids and Implications for Multiple Sclerosis [0.03%]
长非编码RNA X染色体失活特异性转录本(XIST)在神经炎症和髓鞘形成中的作用：源自脑类器官的多发性硬化症研究新见解
Nihan Aktas Pepe,Busra Acar,Gozde Erturk Zararsiz et al.
Nihan Aktas Pepe et al.
Background/Objectives: X-inactive-specific transcript (XIST) is a factor that plays a role in neuroinflammation. This study investigated the role of XIST in neuronal development, neuroinflammation, myelination, and therapeutic responses wit...
Role of Non-Coding RNAs in White and Brown Adipose Tissue Differentiation and Development [0.03%]
非编码RNA在白色和棕色脂肪组织分化及发育中的作用
Lea Sleiman,Sorina Dinescu
Lea Sleiman
Adipocyte differentiation is a complex process in which pluripotent mesenchymal stem cells (MSCs) differentiate and develop into mature fat cells, also known as adipocytes. This process is controlled by various transcription factors, hormon...
Annanda Lyra Ribeiro,Bruno Dallagiovanna
Annanda Lyra Ribeiro
The human genome sequencing revealed a vast complexity of transcripts, with over 80% of the genome being transcribed into non-coding RNAs. In particular, long non-coding RNAs (lncRNAs) have emerged as critical regulators of various cellular...
Decoding Salivary ncRNAomes as Novel Biomarkers for Oral Cancer Detection and Prognosis [0.03%]
解码唾液ncRNA组作为口腔癌检测和预后的新生物标志物
Subhadeep Das,Sampad Basak,Soumyadev Sarkar
Subhadeep Das
Oral cancer (OC) ranks among the most prevalent head and neck cancers, becoming the eleventh most common cancer worldwide with ~350,000 new cases and 177,000 fatalities annually. The rising trend in the occurrence of OC among young individu...
The Role of Non-Coding RNAs in MYC-Mediated Metabolic Regulation: Feedback Loops and Interactions [0.03%]
非编码RNA在MYC介导的代谢调节中的作用：反馈环和相互作用
Aliaa Amr Alamoudi
Aliaa Amr Alamoudi
Metabolic reprogramming is a hallmark of cancer, crucial for supporting the rapid energy demands of tumor cells. MYC, often deregulated and overexpressed, is a key driver of this shift, promoting the Warburg effect by enhancing glycolysis. ...
A miRNA Signature for Non-Invasive Colorectal Cancer Diagnosis in Morocco: miR-21, miR-29a and miR-92a [0.03%]
摩洛哥非侵入性结直肠癌诊断的miRNA特征：miR-21，miR-29a和miR-92a
Sofia Fathi,Oussama Aazzane,Salma Guendaoui et al.
Sofia Fathi et al.
Colorectal cancer (CRC) is the third most diagnosed cancer and a leading cause of cancer-related mortality in Morocco, often detected at late stages. Circulating microRNAs (miRNAs) have emerged as promising non-invasive biomarkers for CRC d...
Chromatin Structure Around Long Non-Coding RNA (lncRNA) Genes in Schistosoma mansoni Gonads [0.03%]
血吸虫 gonad 中长非编码 RNA(lncRNA) 基因周围的染色质结构
Ronaldo C Augusto,Thomas Quack,Christoph G Grevelding et al.
Ronaldo C Augusto et al.
In this study, we employed a total of eight distinct modifications of histone proteins (H3K23ac, H3K27me3, H3K36me3, H3K4me3, H3K9ac, H3K9me3, H4K12ac, and H4K20me1) to discern the various chromatin colors encompassing lncRNA genes in both ...
Single-Cell Transcriptomic Approaches for Decoding Non-Coding RNA Mechanisms in Colorectal Cancer [0.03%]
单细胞转录谱在结肠癌非编码RNA机制解码中的应用
Mahnoor Naseer Gondal,Hafiz Muhammad Umer Farooqi
Mahnoor Naseer Gondal
Non-coding RNAs (ncRNAs) play crucial roles in colorectal cancer (CRC) development and progression. Recent developments in single-cell transcriptome profiling methods have revealed surprising levels of expression variability among seemingly...
A Multi-Input Neural Network Model for Accurate MicroRNA Target Site Detection [0.03%]
用于精确的microRNA靶位点检测的多输入神经网络模型
Mohammad Mohebbi,Amirhossein Manzourolajdad,Ethan Bennett et al.
Mohammad Mohebbi et al.
(1) Background: MicroRNAs are non-coding RNA sequences that regulate cellular functions by targeting messenger RNAs and inhibiting protein synthesis. Identifying their target sites is vital to understanding their roles. However, it is chall...