Hee Kyoung Chung,Lan Xiao,Jian-Ying Wang
Hee Kyoung Chung
The mammalian intestinal epithelium is a rapid self-renewal tissue in the body, serving as a critical interface between the host and the external environment. Maintaining the intestinal epithelium homeostasis requires precise coordination o...
Mario García-Domínguez
Mario García-Domínguez
Neuropathic pain represents a complex, prolonged pain state arising from lesions within the somatosensory nervous system. Despite significant advances in elucidating its pathophysiology, current therapeutic approaches remain largely symptom...
Paraspeckles Are Associated with the Activation and Nuclear Localization of Unphosphorylated miR-34a [0.03%]
未磷酸化的miR-34a的激活及核内定位与Para-specks相关
Graham H Read,Kristen McGreevy,Hanny Issawi et al.
Graham H Read et al.
Background/Objectives: Canonical microRNAs possess a 5' phosphate required for Argonaute binding and activity. However, prior work identified an unphosphorylated, inactive nuclear pool of the important radiation-responsive microRNA, miR-34,...
Monia Cecati,Valentina Pozzi,Valentina Schiavoni et al.
Monia Cecati et al.
Renal cell carcinoma (RCC) represents the most frequent kidney malignancy and remains a major clinical challenge due to its often silent onset, high metastatic potential, and limited responsiveness to conventional chemotherapy. Increasing e...
Comprehensive Schistosoma mansoni Hierarchical Transcriptome Assembly Points to Novel lncRNAs Associated with Sexual Dimorphism [0.03%]
曼氏血吸虫性别二态相关新lncRNA的全面转录组拼接组装
Caio Felipe Freire,Thalles Souza-Lopes,Murilo Sena Amaral et al.
Caio Felipe Freire et al.
Background/Objectives: Schistosomiasis is a neglected tropical disease affecting >200 million people worldwide. Praziquantel is the sole recommended drug against Schistosoma mansoni; however, it lacks activity against juvenile forms and can...
Vape-Associated lncRNA Transcript 1 (VALT1) Amplifies the Tumorigenic Effects of e-Cigarette Vapor in Lung Epithelial Cells [0.03%]
与电子烟蒸汽致癌作用相关的长链非编码RNA VALT1促进呼吸道上皮细胞的肿瘤发生
Daniel Angelo R Mirador,Jose Lorenzo M Ferrer,Kim Denyse Hao Lin et al.
Daniel Angelo R Mirador et al.
Background/Objectives: Lung cancer remains a major global health burden, largely driven by cigarette use. Although electronic cigarettes (e-cigarettes) are viewed as safer alternatives due to their reduced chemical load, growing evidence sh...
Circular and Long Non-Coding RNAs in Cancer Metabolism: Dual Perspective of Biomarkers and Therapeutic Targets [0.03%]
癌症代谢中的环状和长非编码RNA：生物标志物和治疗靶点的双重视角
Francesca Pia Carbone,Stefania Hanau,Nicoletta Bianchi
Francesca Pia Carbone
Background/Objectives: Metabolic reprogramming is a hallmark of cancer, enabling tumor cells to sustain proliferation, survive under metabolic stress, and develop therapeutic resistance. While oncogenic signaling pathways regulating cancer ...
The Stiff Side of Cancer: How Matrix Mechanics Rewrites Non-Coding RNA Expression Programs [0.03%]
癌症的刚性一面：细胞外基质力学如何重写非编码RNA表达程序
Alma D Campos-Parra,Jonathan Puente-Rivera,César López-Camarillo et al.
Alma D Campos-Parra et al.
Extracellular matrix (ECM) stiffening is a defining biophysical feature of solid tumors that reshape gene regulation through mechanotransduction. Increased collagen crosslinking and stromal remodeling enhance integrin engagement, focal-adhe...
Computational Analysis of Telomerase RNA Evolution in Caenorhabditis Species [0.03%]
计算分析Caenorhabditis物种端粒酶RNA的进化
Christopher Klapproth,Franziska Reinhardt,Peter F Stadler et al.
Christopher Klapproth et al.
Background/Objectives: The telomerase RNA (TR) is an indispensable part of the telomerase protein complex responsible for telomere elongation in most eukaryotic species. Although the telomere terminal repeat sequence (TTAGGC)n in Caenorhabd...
Extracellular Small RNAs in Human Milk: Molecular Profiles, Stability and Fragment-Specific Responses in Cell-Based Assays [0.03%]
人类乳汁中的细胞外小RNA：分子特征、稳定性及基于细胞实验的片段特异性反应
Clara Claus,Carla Borini Etichetti,Bruno Costa et al.
Clara Claus et al.
Background/Objectives: Human milk is a complex biological fluid containing not only macro- and micronutrients but also diverse bioactive molecules, including extracellular RNAs. Although RNA has been detected in milk for decades, only a sub...