Jessica Kreutz,Tijana Mitić,Andrea Caporali
Jessica Kreutz
The emergence of single-cell sequencing and computational analysis has dramatically improved our understanding of cellular diversity and gene expression dynamics. The rapid advancement of high-throughput omics technologies has led to an exp...
Javier Avalos,Adrián Perera-Bonaño,M Carmen Limón
Javier Avalos
Long noncoding RNAs (lncRNAs) are transcripts generated by polymerase II, therefore subject to 5' capping and 3' polyadenylation, categorized as such when they are at least 200 nt in size and lack coding function. The lncRNAs were initially...
microRNA Biomarkers in Paediatric Infection Diagnostics-Bridging the Gap Between Evidence and Clinical Application: A Scoping Review [0.03%]
儿童感染诊断中微小核糖核酸生物标志物的证据与临床应用缺口：系统综述
Oenone Rodgers,Anna De Beer,Thomas Waterfield
Oenone Rodgers
Background: Distinguishing between bacterial and viral infections in children remains a significant challenge for clinicians. Traditional biomarkers have limited utility, often leading to antibiotic overprescription due t...
Shailendra S Maurya,Sarita Maurya,Sumit K Chaturvedi
Shailendra S Maurya
Acute myeloid leukemia (AML) is a highly heterogeneous disease, with significantly higher incidence and fatality rates in the elderly. Even with recent decades of research progress in AML, the exact etiology of this deadly disease is still ...
Long Non-Coding RNAs in Psoriasis: A Comprehensive Review of Expression Profiles, Mechanistic Insights, Genetic Associations, and Their Clinical Implications [0.03%]
银屑病长链非编码RNA的研究：表达图谱、机制解析、遗传易感及临床意义综述
Judit Danis,Márta Széll
Judit Danis
Psoriasis is a chronic inflammatory skin disorder affecting approximately 2% of the global population, characterized by abnormal keratinocyte proliferation and dysregulated immune responses. This review examines the emerging role of long no...
Chromatin-Associated RNAs Regulate Gene Expression and Chromatin Structure [0.03%]
染色质相关RNA调控基因表达和染色质结构
Bingning Xie,Ann Dean
Bingning Xie
Inside the eukaryotic nucleus, various RNAs are associated with chromatin. These include protein-coding pre-mRNA and different types of non-coding RNAs that are referred to as chromatin-associated RNAs (caRNAs). Recent studies have revealed...
XIST Loss Induces Variable Transcriptional Responses Dependent on Cell States [0.03%]
XIST丢失诱发依赖于细胞状态的转录响应变化
Dongning Chen,Ikrame Naciri,Jie Wu et al.
Dongning Chen et al.
Background/Objectives: The X-inactivation specific transcript (XIST) is a long noncoding RNA playing a crucial regulatory role in X chromosome inactivation (XCI)-a transcriptional regulatory process that silences one of the two X chromosome...
Cellular Delivery of Functional AntimiR Conjugated to Bio-Produced Gold Nanoparticles [0.03%]
生物生产的金纳米颗粒偶联抗miR的细胞递送
Parastoo Pourali,Veronika Benson
Parastoo Pourali
Background/Objectives: Bio-produced gold nanoparticles (AuNPs) are effective carriers of short RNAs into specialized mammalian cells. Their potential application is still limited by scarce knowledge on their uptake and intracellular fate. G...
Human-Specific Suppression of Hepatic Fatty Acid Catabolism by RNA-Binding Protein HuR [0.03%]
RNA结合蛋白HuR特异性抑制人肝脏脂肪酸分解代谢作用
Shohei Takaoka,Marcos E Jaso-Vera,Xiangbo Ruan
Shohei Takaoka
RNA-binding proteins (RBPs) play essential roles in all major steps of RNA processing. Genetic studies in human and mouse models support that many RBPs are crucial for maintaining homeostasis in key tissues/organs, but to what extent the fu...
Navigating the Landscape of Exosomal microRNAs: Charting Their Pivotal Role as Biomarkers in Hematological Malignancies [0.03%]
外泌体微小RNA的研究现状及其在血液系统恶性肿瘤生物标志物中的作用展望
Manlio Fazio,Fabio Stagno,Giuseppa Penna et al.
Manlio Fazio et al.
Under physiological and pathological conditions, all cells release extracellular vesicles named exosomes, which act as transporters of lipidic, protein, and genetic material from parent to recipient cells. Neoplastic cells can secrete highe...