The Stiff Side of Cancer: How Matrix Mechanics Rewrites Non-Coding RNA Expression Programs [0.03%]
癌症的刚性一面：细胞外基质力学如何重写非编码RNA表达程序
Alma D Campos-Parra,Jonathan Puente-Rivera,César López-Camarillo et al.
Alma D Campos-Parra et al.
Extracellular matrix (ECM) stiffening is a defining biophysical feature of solid tumors that reshape gene regulation through mechanotransduction. Increased collagen crosslinking and stromal remodeling enhance integrin engagement, focal-adhe...
Computational Analysis of Telomerase RNA Evolution in Caenorhabditis Species [0.03%]
计算分析Caenorhabditis物种端粒酶RNA的进化
Christopher Klapproth,Franziska Reinhardt,Peter F Stadler et al.
Christopher Klapproth et al.
Background/Objectives: The telomerase RNA (TR) is an indispensable part of the telomerase protein complex responsible for telomere elongation in most eukaryotic species. Although the telomere terminal repeat sequence (TTAGGC)n in Caenorhabd...
Extracellular Small RNAs in Human Milk: Molecular Profiles, Stability and Fragment-Specific Responses in Cell-Based Assays [0.03%]
人类乳汁中的细胞外小RNA：分子特征、稳定性及基于细胞实验的片段特异性反应
Clara Claus,Carla Borini Etichetti,Bruno Costa et al.
Clara Claus et al.
Background/Objectives: Human milk is a complex biological fluid containing not only macro- and micronutrients but also diverse bioactive molecules, including extracellular RNAs. Although RNA has been detected in milk for decades, only a sub...
Samuel J Gonzalez,Edgardo Linares,Allison M Porman Swain et al.
Samuel J Gonzalez et al.
This review provides a thorough survey of long noncoding RNAs that bear the RNA modification N6-methyladenosine (m6A) and current work to understand the resulting mechanistic and biological consequences. We give an overview of lncRNA and m6...
Hypercholesterolemia Impairs the Expression of Angiogenic MicroRNAs in Extracellular Vesicles Within Ischemic Skeletal Muscles [0.03%]
高胆固醇血症损害缺血性骨骼肌内细胞外囊泡中促血管生成微RNA的表达
Nozha Raguema,Sylvie Dussault,Kevin Sawaya et al.
Nozha Raguema et al.
Background/Objectives: In severe peripheral artery disease (PAD) with limb ischemia, hypercholesterolemia (HC) is associated with impaired neovascularization. Extracellular vesicles (EVs) are present within ischemic muscles, and they contai...
Functional and Molecular Characterization of Extracellular Vesicles Enriched in Exosomes Released by Bone Marrow Mesenchymal Stromal Cells Exposed to IFNγ in Combination with Autophagy Modulators Tamoxifen or Chloroquine [0.03%]
干扰素γ联合自噬调节剂他莫昔芬或氯喹处理后骨髓间充质基质细胞释放的外泌体的功能和分子特征及其富集的细胞外囊泡的功能和分子特征的表征
Vladimir Beljanski,Maria J Moreno Hollweg,Renee Potens et al.
Vladimir Beljanski et al.
Background/Objectives: Bone marrow mesenchymal stromal cells (MSCs) are therapeutic cells that adopt an immunomodulatory phenotype when exposed to pro-inflammatory cytokines. Recent research efforts uncovered that many therapeutic benefits ...
The Role of microRNAs as Potential Biomarkers in Diffuse Large B-Cell Lymphoma [0.03%]
微RNA作为弥漫性大B细胞淋巴瘤潜在生物标志物的作用研究进展
Eirini Panteli,Epameinondas Koumpis,Vasileios Georgoulis et al.
Eirini Panteli et al.
Diffuse large B-cell lymphoma (DLBCL) is the most common and clinically aggressive subtype of non-Hodgkin lymphoma (NHL). While novel therapies such as rituximab and polatuzumab vedotin have led to improved outcomes, approximately 35% of pa...
Transposable Element-Derived miR-28-5p and miR-708-5p: Exploring Potential Roles in Lung Cancer [0.03%]
可移动元件来源的miR-28-5p和miR-708-5p：探究在肺癌中的潜在功能作用
Sergiu Chira,Cornelia Braicu,Stefan Strilciuc et al.
Sergiu Chira et al.
Background: Transposable elements are normally silenced by epigenetic mechanisms; however, during malignant transformation, epigenetic alterations enable transposons to produce functional molecules like miRNAs. Among these, LINE-2 (L2) elem...
MicroRNAs in Breast Cancer Bone Metastasis Formation and Progression: An Overview on Recent Progress in This Research Field [0.03%]
微小核糖核酸与乳腺癌骨转移：近期研究进展概述
Margherita Puppo
Margherita Puppo
Bone metastasis is a common and severe complication in advanced stages of breast cancer (BC) that is characterised by limited treatment options and poor patient prognosis. MicroRNAs (miRNAs) are a large class of regulatory small non-coding ...
Morgane Gourvest,Coen van Solingen
Morgane Gourvest
CARINH is an intriguing long noncoding RNA whose unique regulatory functions intersect the seemingly distinct processes of innate immunity and cancer development. Notably, CARINH is conserved across species, offering powerful experimental m...