Kajetan Kiełbowski,Anna Jędrasiak,Estera Bakinowska et al.
Kajetan Kiełbowski et al.
Psoriasis is a chronic immune-mediated disease with complex pathogenesis. The altered proliferation and differentiation of keratinocytes, together with the activity of dendritic cells and T cells, are crucial drivers of psoriasis progressio...
In Silico Prediction of Maize microRNA as a Xanthine Oxidase Inhibitor: A New Approach to Treating Hyperuricemia Patients [0.03%]
基于计算预测的玉米microRNA作为黄嘌呤氧化酶抑制剂及治疗高尿酸血症患者的新型策略研究
Manas Joshi,Mohd Mabood Khan
Manas Joshi
Introduction: Hyperuricemia is characterized by increased uric acid (UA) in the body. The ability to block xanthine oxidase (XO) is a useful way to check how different bioactive molecules affect hyperuricemia. Previous re...
Plasma Humanin and Non-Coding RNAs as Biomarkers of Endothelial Dysfunction in Rheumatoid Arthritis: A Pilot Study [0.03%]
血浆人因素和非编码RNA作为类风湿关节炎血管内皮功能障碍生物标志物的初步研究
Donatella Coradduzza,Sara Cruciani,Biagio Di Lorenzo et al.
Donatella Coradduzza et al.
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disorder associated with an increased risk of cardiovascular disease (CVD), largely driven by peripheral endothelial dysfunction (ED). Humanin, a mitochondrial-derived peptide, h...
Integrative Analysis of Whole-Genome and Transcriptomic Data Reveals Novel Variants in Differentially Expressed Long Noncoding RNAs Associated with Asthenozoospermia [0.03%]
整合全基因组和转录组数据分析发现与弱精症相关的差异表达长链非编码RNA的新变异
Maria-Anna Kyrgiafini,Maria Katsigianni,Themistoklis Giannoulis et al.
Maria-Anna Kyrgiafini et al.
Background/Objectives: Asthenozoospermia, characterized by reduced sperm motility, is a common cause of male infertility. Emerging evidence suggests that noncoding RNAs, particularly long noncoding RNAs (lncRNAs), play a critical role in th...
Alessia Finotti,Roberto Gambari
Alessia Finotti
The discovery of the involvement of microRNAs (miRNAs) in cystic fibrosis (CF) has generated increasing interest in the past years, due to their possible employment as a novel class of drugs to be studied in pre-clinical settings of therape...
LncRNA 3222401L13Rik Is Upregulated in Aging Astrocytes and Regulates Neuronal Support Function Through Interaction with Npas3 [0.03%]
长非编码RNA 3222401L13Rik在衰老星形胶质细胞中高表达并通过与Npas3互作调控神经元支持功能
Sophie Schröder,M Sadman Sakib,Dennis M Krüger et al.
Sophie Schröder et al.
Aging leads to cognitive decline and increased risk of neurodegenerative diseases. While molecular changes in central nervous system (CNS) cells contribute to this decline, the mechanisms are not fully understood. Long non-coding RNAs (lncR...
RNA Metabolism and the Role of Small RNAs in Regulating Multiple Aspects of RNA Metabolism [0.03%]
RNA代谢及小RNA在调控多种RNA代谢方面的功能
Pranav Dawar,Indra Adhikari,Swarupa Nanda Mandal et al.
Pranav Dawar et al.
RNA metabolism is focused on RNA molecules and encompasses all the crucial processes an RNA molecule may or will undergo throughout its life cycle. It is an essential cellular process that allows all cells to function effectively. The trans...
The 2024 Nobel Prize in Physiology or Medicine: microRNA Takes Center Stage [0.03%]
2024年诺贝尔生理学或医学奖：microRNA成为焦点
George A Calin,Florent Hubé,Michael R Ladomery et al.
George A Calin et al.
The Non-coding Journal Editorial Board Members would like to congratulate Victor Ambros and Gary Ruvkun, who were jointly awarded the 2024 Nobel Prize in Physiology or Medicine for their groundbreaking discovery of microRNAs and the role of...
Urinary miRNA Expression in Pre-Eclampsia During Early and Mid-Pregnancy [0.03%]
妊娠早期和中期子痫前期患者尿液miRNA表达谱的筛选及验证
Roman A Illarionov,Anastasia R Maltseva,Olga V Pachuliia et al.
Roman A Illarionov et al.
Background: Pre-eclampsia (PE) is a serious condition affecting 2-8% of pregnancies worldwide, leading to high maternal and fetal morbidity and mortality. MicroRNAs (miRNAs), small non-coding RNA molecules, have emerged as potential biomark...
Identification of Tumor-Suppressive miR-30a-3p Controlled Genes: ANLN as a Therapeutic Target in Breast Cancer [0.03%]
鉴定肿瘤抑制性miR-30a-3p靶基因：ANLN作为乳腺癌治疗靶点
Reiko Mitsueda,Ayako Nagata,Hiroko Toda et al.
Reiko Mitsueda et al.
Our recently created RNA-sequence-based microRNA (miRNA) expression signature in breast cancer clinical specimens revealed that some miR-30 family members were significantly downregulated in cancer tissues. Based on TCGA database analyses, ...