Exploratory Machine Learning Analysis of circRNA-Derived Molecular Features in Autism Spectrum Disorder [0.03%]
自闭症谱系障碍中circRNA衍生分子特征的探索性机器学习分析
Raunak Sharda,Valentina L Kouznetsova,Igor F Tsigelny
Raunak Sharda
Background/Objectives: Autism Spectrum Disorder (ASD) is a set of neurological and neurodevelopmental disorders characterized by difficulties in social communication and interaction, repetitive behaviors, and sensory processing differences....
Urinary Exosomal microRNAs as a Novel Approach to Study People with Multiple Sclerosis and Severe Gait Disability: A Preliminary Observation [0.03%]
尿液外泌体microRNA作为研究多发性硬化症患者重度步态残疾的新方法：初步观察结果
Silvia Grassilli,Andrea Baroni,Marina Pierantoni et al.
Silvia Grassilli et al.
Background: MiRNAs within extracellular vesicles can encompass body barriers, reflecting stage, progression, and response to treatments of various diseases, including multiple sclerosis (MS)-a chronic immune-mediated disease of the central ...
Hnf1aos1 as a Metabolic Coordinator of Hepatic Lipid Homeostasis and Feedback Control [0.03%]
Hnf1aos1作为肝脏脂质稳态和反馈调控的代谢协调因子
Beshoy Armanios,Jing Jin,Ankit P Laddha et al.
Beshoy Armanios et al.
Background: Long noncoding RNAs (lncRNAs) have emerged as critical regulators of hepatic metabolism and disease progression. The hepatocyte nuclear factor 1 alpha antisense 1 (HNF1A-AS1) lncRNA modulates liver-specific transcription factors...
Hee Kyoung Chung,Lan Xiao,Jian-Ying Wang
Hee Kyoung Chung
The mammalian intestinal epithelium is a rapid self-renewal tissue in the body, serving as a critical interface between the host and the external environment. Maintaining the intestinal epithelium homeostasis requires precise coordination o...
Mario García-Domínguez
Mario García-Domínguez
Neuropathic pain represents a complex, prolonged pain state arising from lesions within the somatosensory nervous system. Despite significant advances in elucidating its pathophysiology, current therapeutic approaches remain largely symptom...
Paraspeckles Are Associated with the Activation and Nuclear Localization of Unphosphorylated miR-34a [0.03%]
未磷酸化的miR-34a的激活及核内定位与Para-specks相关
Graham H Read,Kristen McGreevy,Hanny Issawi et al.
Graham H Read et al.
Background/Objectives: Canonical microRNAs possess a 5' phosphate required for Argonaute binding and activity. However, prior work identified an unphosphorylated, inactive nuclear pool of the important radiation-responsive microRNA, miR-34,...
Monia Cecati,Valentina Pozzi,Valentina Schiavoni et al.
Monia Cecati et al.
Renal cell carcinoma (RCC) represents the most frequent kidney malignancy and remains a major clinical challenge due to its often silent onset, high metastatic potential, and limited responsiveness to conventional chemotherapy. Increasing e...
Comprehensive Schistosoma mansoni Hierarchical Transcriptome Assembly Points to Novel lncRNAs Associated with Sexual Dimorphism [0.03%]
曼氏血吸虫性别二态相关新lncRNA的全面转录组拼接组装
Caio Felipe Freire,Thalles Souza-Lopes,Murilo Sena Amaral et al.
Caio Felipe Freire et al.
Background/Objectives: Schistosomiasis is a neglected tropical disease affecting >200 million people worldwide. Praziquantel is the sole recommended drug against Schistosoma mansoni; however, it lacks activity against juvenile forms and can...
Vape-Associated lncRNA Transcript 1 (VALT1) Amplifies the Tumorigenic Effects of e-Cigarette Vapor in Lung Epithelial Cells [0.03%]
与电子烟蒸汽致癌作用相关的长链非编码RNA VALT1促进呼吸道上皮细胞的肿瘤发生
Daniel Angelo R Mirador,Jose Lorenzo M Ferrer,Kim Denyse Hao Lin et al.
Daniel Angelo R Mirador et al.
Background/Objectives: Lung cancer remains a major global health burden, largely driven by cigarette use. Although electronic cigarettes (e-cigarettes) are viewed as safer alternatives due to their reduced chemical load, growing evidence sh...
Circular and Long Non-Coding RNAs in Cancer Metabolism: Dual Perspective of Biomarkers and Therapeutic Targets [0.03%]
癌症代谢中的环状和长非编码RNA：生物标志物和治疗靶点的双重视角
Francesca Pia Carbone,Stefania Hanau,Nicoletta Bianchi
Francesca Pia Carbone
Background/Objectives: Metabolic reprogramming is a hallmark of cancer, enabling tumor cells to sustain proliferation, survive under metabolic stress, and develop therapeutic resistance. While oncogenic signaling pathways regulating cancer ...